INT96689

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Context Info
Confidence 0.01
First Reported 2001
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 17 99.52 Very High Very High Very High
mu opioid receptor 17 99.20 Very High Very High Very High
tolerance 3 95.36 Very High Very High Very High
dopamine receptor 2 95.36 Very High Very High Very High
addiction 2 94.80 High High
opioid receptor 11 88.80 High High
agonist 40 75.00 Quite High
Kappa opioid receptor 3 75.00 Quite High
narcan 19 50.84 Quite High
antagonist 20 40.24 Quite Low
Disease Link Frequency Relevance Heat
Decompression Sickness 1 82.96 Quite High
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Tics 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The conservation of the accessibility pattern on the cytoplasmic side of 6.54 suggests that this region may be important for receptor activation.
Spec (may) Positive_regulation (important) of Positive_regulation (activation) of receptor
1) Confidence 0.01 Published 2001 Journal Biochemistry Section Abstract Doc Link 11434771 Disease Relevance 0.08 Pain Relevance 0.23
In some cases the increase in receptor basal activity was induced by chronic morphine administration suggesting that constitutive activity may contribute to the development of drug tolerance and dependence.
Positive_regulation (induced) of Positive_regulation (increase) of receptor associated with addiction, tolerance and morphine
2) Confidence 0.00 Published 2003 Journal BMC Pharmacol Section Abstract Doc Link PMC317294 Disease Relevance 0 Pain Relevance 0.35

General Comments

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