INT96693

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 37.11
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
ear 3
cartilage 2
eye 2
canal 1
tail 1
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 54 100.00 Very High Very High Very High
Earache 21 99.58 Very High Very High Very High
alcohol 2 99.16 Very High Very High Very High
rheumatoid arthritis 61 98.52 Very High Very High Very High
Osteoarthritis 222 96.84 Very High Very High Very High
Analgesic 8 96.40 Very High Very High Very High
Inflammation 85 93.60 High High
corticosteroid 7 79.88 Quite High
Antihistamine 17 79.12 Quite High
imagery 32 70.00 Quite High
Disease Link Frequency Relevance Heat
Otitis Media 742 100.00 Very High Very High Very High
Congenital Toxoplasmosis 224 100.00 Very High Very High Very High
Eye Disease 168 100.00 Very High Very High Very High
Lower Respiratory Tract Infection 39 100.00 Very High Very High Very High
Pain 37 100.00 Very High Very High Very High
Meningitis 6 99.78 Very High Very High Very High
Common Cold 15 99.68 Very High Very High Very High
Earache 15 99.58 Very High Very High Very High
Viral Infection 44 99.44 Very High Very High Very High
Otitis Media With Effusion 210 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the evidence from the children with eye and brain signs associated with congenitally acquired toxoplasmosis in these two cohorts was for association with eye disease and these two previously recognized eye disorder genes, ABCA4 and COL2A1.
COL2A1 Binding (association) of in eye associated with eye disease and toxoplasmosis
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.48 Pain Relevance 0
Overall, the evidence from the children with eye and brain signs associated with congenitally acquired toxoplasmosis in these two cohorts was for association with eye disease and these two previously recognized eye disorder genes, ABCA4 and COL2A1.
COL2A1 Binding (recognized) of in eye associated with eye disease and toxoplasmosis
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.47 Pain Relevance 0
The alternative, naturopathic herbal extract medications, may offer many new possibilities in the management of ear pain associated with AOM.
AOM Binding (associated) of in ear
3) Confidence 0.42 Published 2003 Journal Pediatrics Section Body Doc Link 12728112 Disease Relevance 0 Pain Relevance 0
Common viruses that cause upper respiratory tract infection are frequently associated with AOM and new-onset OME.
AOM Binding (associated) of in upper respiratory tract associated with common cold, otitis media and otitis media with effusion
4) Confidence 0.41 Published 2009 Journal Med. J. Aust. Section Abstract Doc Link 19883356 Disease Relevance 2.21 Pain Relevance 0.08
OBJECTIVE: Acute otitis media (AOM) is common in children, yet the optimal management of ear pain associated with AOM has not been well studied.
AOM Binding (associated) of in ear associated with pain and otitis media
5) Confidence 0.41 Published 2008 Journal Arch. Dis. Child. Section Abstract Doc Link 18156478 Disease Relevance 0.55 Pain Relevance 0.26
URTI in association with AOM is well-documented (18,19,20,21).
AOM Binding (association) of associated with otitis media
6) Confidence 0.41 Published 2007 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2754010 Disease Relevance 0.83 Pain Relevance 0
Several studies have reported an association of AOM with viral URTIs and high resolution rate between 75% and 90% in three months follow-up (18,19,24).
AOM Binding (association) of associated with otitis media
7) Confidence 0.41 Published 2007 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2754010 Disease Relevance 0.87 Pain Relevance 0
For the EMSCOT cohort, no significant associations were observed for any SNPs at ABCA4 or COL2A1 when congenitally infected children of mothers with primary gestational infection were compared with children of mothers with primary gestational infection who did not transmit infection to the fetus (Table 1 and data not shown).
COL2A1 Neg (no) Binding (associations) of associated with infection
8) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.10 Pain Relevance 0
Polymorphisms at COL2A1 encoding type II collagen associate only with ocular disease.
COL2A1 Binding (associate) of associated with eye disease
9) Confidence 0.36 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2390765 Disease Relevance 1.22 Pain Relevance 0
We chose to look specifically for associations with ABCA4 and COL2A1 (a) because both had defined single gene disorders that result in congenital or early onset ocular disease; and (b) some parallels in clinical pathology or putative pathogenic mechanisms could be drawn between the genetic disorders and ocular disease induced by T. gondii infection in utero.
COL2A1 Binding (associations) of associated with infection and eye disease
10) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.15 Pain Relevance 0.03
Herein we examined the specific genetic hypothesis that polymorphisms in two genes known to be associated with ocular disease, ABCA4 and COL2A1, are associated with ocular disease caused by congenital toxoplasmosis.
COL2A1 Spec (examined) Binding (associated) of associated with congenital toxoplasmosis and eye disease
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.44 Pain Relevance 0
Possible explanations for the observed patterns of association between COL2A1 and clinical signs in congenital toxoplasmosis are (a) that the etiological variant only influences expression or function of the non-silenced exon 2-containing IIA long-form allele; or (b) the disease-causing variant is common to both isoforms but does not manifest as skeletal abnormalities due to the silencing of isoform IIB expressed in cartilage.
COL2A1 Binding (association) of in cartilage associated with congenital anomalies, congenital toxoplasmosis and disease
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.05 Pain Relevance 0
These associations between clinical outcomes of congenital toxoplasmosis and polymorphisms at ABCA4 and COL2A1 provide novel insight into the molecular pathways that can be affected by congenital infection with this parasite.



COL2A1 Binding (associations) of associated with congenital toxoplasmosis and infection
13) Confidence 0.35 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2390765 Disease Relevance 1.05 Pain Relevance 0
In a most recent prospective study on purulent meningitis [11], the association of AOM was found in half of the patients [14].


AOM Binding (association) of associated with otitis media and meningitis
14) Confidence 0.34 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC1876255 Disease Relevance 1.99 Pain Relevance 0
Streptococci pneumoniae with intermediary bacterial resistance to penicillin are particularly associated with recurrent AOM.
AOM Binding (associated) of in intermediary associated with mrsa infection and otitis media
15) Confidence 0.34 Published 2007 Journal Eur J Pediatr Section Abstract Doc Link PMC1876255 Disease Relevance 1.87 Pain Relevance 0.04
AOM (or suppurative OM) was common, usually not associated with ear pain, frequently bilateral, and often associated with perforation of the TM.
AOM Binding (associated) of in ear associated with pain and otitis media
16) Confidence 0.32 Published 2005 Journal BMC Pediatr Section Body Doc Link PMC1177962 Disease Relevance 0.68 Pain Relevance 0.10
PARTICIPANTS: One hundred three children aged 6 to 18 years who were diagnosed with otalgia associated with AOM.
AOM Binding (associated) of
17) Confidence 0.32 Published 2001 Journal Arch Pediatr Adolesc Med Section Body Doc Link 11434846 Disease Relevance 0.14 Pain Relevance 0
The patients were children aged 6 months to 12 years who were diagnosed with AOM.
AOM Binding (diagnosed) of
18) Confidence 0.32 Published 2010 Journal Pediatrics Section Body Doc Link 20100746 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: Although management of AOM without antibiotics has not increased after the publication of the 2004 American Academy of Pediatrics and American Academy of Family Physicians clinical practice guideline, children who did not receive antibiotics were more likely to have mild infections.
AOM Binding (management) of
19) Confidence 0.32 Published 2010 Journal Pediatrics Section Body Doc Link 20100746 Disease Relevance 0 Pain Relevance 0
Our objective was to compare the management of AOM after publication of the 2004 guideline.
AOM Binding (management) of associated with otitis media
20) Confidence 0.32 Published 2010 Journal Pediatrics Section Abstract Doc Link 20100746 Disease Relevance 0.45 Pain Relevance 0.19

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