INT96694

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 0.96
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Slc27a5) protein complex (Slc27a5) ligase activity (Slc27a5)
lipid metabolic process (Slc27a5)
Anatomy Link Frequency
liver 1
Slc27a5 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Felbinac, which is a substrate, inhibited the activity of this medium chain acyl-CoA synthetase for hexanoic acid (IC50 = 25 microM).
Negative_regulation (inhibited) of acyl-CoA synthetase
1) Confidence 0.53 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11434910 Disease Relevance 0.14 Pain Relevance 0.22
Enoxacin and ofloxacin inhibited this medium chain acyl-CoA synthetase in a mixed-type manner with K(i) values of 23.7 and 38.2 microM, respectively.
Negative_regulation (inhibited) of acyl-CoA synthetase
2) Confidence 0.53 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11434910 Disease Relevance 0.15 Pain Relevance 0.22
The concomitant presence of enoxacin and felbinac strongly inhibited this medium chain acyl-CoA synthetase.
Negative_regulation (inhibited) of acyl-CoA synthetase
3) Confidence 0.53 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11434910 Disease Relevance 0.14 Pain Relevance 0.23
Diflunisal, nalidixic acid, salicylic acid, 2-hydroxynaphthoic acid, and 2-hydroxydodecanoic acid inhibited competitively this medium chain acyl-CoA synthetase with K(i) values of 0.6, 12.4, 19.6, 13.4, and 15.0 microM, respectively.
Negative_regulation (inhibited) of acyl-CoA synthetase
4) Confidence 0.46 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11434910 Disease Relevance 0.16 Pain Relevance 0.21
The inhibitory effects of quinolone antimicrobial agents and nonsteroidal anti-inflammatory drugs on purified mouse liver mitochondrial medium chain acyl-CoA synthetase catalyzing the first reaction of glycine conjugation were examined, using hexanoic acid as a substrate.
Spec (examined) Negative_regulation (effects) of acyl-CoA synthetase in liver associated with inflammation and cinod
5) Confidence 0.39 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11434910 Disease Relevance 0.17 Pain Relevance 0.17
Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase.
Negative_regulation (effect) of acyl-CoA synthetase associated with inflammation and cinod
6) Confidence 0.39 Published 2001 Journal Biochem. Pharmacol. Section Title Doc Link 11434910 Disease Relevance 0.20 Pain Relevance 0.25

General Comments

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