INT96700

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.93
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
DRG 5
plasma 2
spinal 1
sciatic nerve 1
neurons 1
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 10 100.00 Very High Very High Very High
spinal dorsal horn 6 100.00 Very High Very High Very High
Spinal nerve ligature 8 99.98 Very High Very High Very High
Pain 7 99.56 Very High Very High Very High
Sciatic nerve 5 99.56 Very High Very High Very High
Neuropathic pain 7 97.96 Very High Very High Very High
Glutamate 5 97.20 Very High Very High Very High
Thermal hyperalgesia 4 94.44 High High
allodynia 5 93.44 High High
Dermatone 1 84.64 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Cancer 9 100.00 Very High Very High Very High
Neuropathic Pain 13 97.96 Very High Very High Very High
Toxicity 8 97.56 Very High Very High Very High
Pain 4 96.64 Very High Very High Very High
Hyperalgesia 4 94.44 High High
Alzheimer's Dementia 3 86.24 High High
Hypoxia 1 85.72 High High
Death 6 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat.
Positive_regulation (induces) of Positive_regulation (upregulation) of tumor necrosis factor receptors 1 in dorsal root ganglia associated with necrosis, cancer and spinal nerve ligature
1) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12875915 Disease Relevance 0.67 Pain Relevance 1.02
In contrast, the sciatic nerve ligature for 2 weeks caused a similar increase of TNFR1 IF in the neurons and their SGC of both ipsi- and contralateral DRG.
Positive_regulation (caused) of in sciatic nerve Positive_regulation (increase) of TNFR1 IF in neurons associated with sciatic nerve
2) Confidence 0.45 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16705482 Disease Relevance 0.25 Pain Relevance 0.47
These data suggest that the upregulation of TNF-alpha and TNFR1 in DRG and spinal dorsal horn is essential for the initiation but not for maintenance of the neuropathic pain induced by L5 VRT.
Neg (not) Positive_regulation (essential) of Positive_regulation (upregulation) of TNFR1 in DRG associated with dorsal root ganglion, spinal dorsal horn and neuropathic pain
3) Confidence 0.44 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.09 Pain Relevance 0.88
While activation of the TNFR1 pathway leads to a transient NF?
Positive_regulation (leads) of Positive_regulation (activation) of TNFR1
4) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.77 Pain Relevance 0.16
Capsaicin-induced desensitization also resulted in significantly higher plasma levels of IL-6 and TNF 1 but not 4 h after LPS challenge.
Positive_regulation (resulted) of Positive_regulation (levels) of TNF 1 in plasma
5) Confidence 0.19 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11435748 Disease Relevance 0.07 Pain Relevance 0
These data suggest that the upregulation of TNF-alpha and TNFR1 in DRG and spinal dorsal horn is essential for the initiation but not for maintenance of the neuropathic pain induced by L5 VRT.
Neg (not) Positive_regulation (essential) of in spinal Positive_regulation (upregulation) of TNFR1 in DRG associated with dorsal root ganglion, spinal dorsal horn and neuropathic pain
6) Confidence 0.15 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.09 Pain Relevance 0.88

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