INT96703

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.42
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
neurons 4
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 14 100.00 Very High Very High Very High
tetrodotoxin 2 99.68 Very High Very High Very High
neurotrophin 3 19 98.16 Very High Very High Very High
Hippocampus 7 80.56 Quite High
Glutamate 2 78.24 Quite High
nMDA receptor 4 75.60 Quite High
Pain 1 74.84 Quite High
Nerve growth factor 26 71.64 Quite High
amygdala 3 49.12 Quite Low
cerebral cortex 3 48.32 Quite Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 1 99.80 Very High Very High Very High
Neurodegenerative Disease 1 91.60 High High
Huntington's Chorea 1 88.00 High High
Pain 1 74.84 Quite High
Nervous System Malformation 1 70.52 Quite High
Adhesions 15 18.68 Low Low
Body Weight 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (as) of Localization (morphogens) of neurotrophin
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of Localization (morphogens) of neurotrophin
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of Localization (several) of neurotrophin
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A single-nucleotide polymorphism in the human BDNF gene, resulting in a valine to methionine substitution (Val66Met) in the prodomain, has been shown to lead to reduced activity-induced BDNF secretion and memory impairment [7].
Negative_regulation (reduced) of Localization (secretion) of BDNF associated with cognitive disorder
4) Confidence 0.33 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.42 Pain Relevance 0.17
MK-801 (dizocilpine) and tetrodotoxin (TTX) entirely blocked neurotrophin-evoked somatostatin release and [Ca(2+)](i) rise in response to BDNF and NT-3 application in most neurons.
Negative_regulation (blocked) of Localization (release) of neurotrophin-evoked somatostatin in neurons associated with tetrodotoxin, neurotrophin 3 and somatostatin
5) Confidence 0.18 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11435757 Disease Relevance 0 Pain Relevance 0.85
MK-801 (dizocilpine) and tetrodotoxin (TTX) entirely blocked neurotrophin-evoked somatostatin release and [Ca(2+)](i) rise in response to BDNF and NT-3 application in most neurons.
Negative_regulation (blocked) of Localization (release) of neurotrophin-evoked somatostatin in neurons associated with tetrodotoxin, neurotrophin 3 and somatostatin
6) Confidence 0.13 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11435757 Disease Relevance 0 Pain Relevance 0.85

General Comments

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