INT96720

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNA11) plasma membrane (GNA11) GTPase activity (GNA11)
cytoplasm (GNA11) signal transducer activity (GNA11)
GNA11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 40 94.24 High High
Lasting pain 4 62.36 Quite High
agonist 8 58.72 Quite High
Serotonin 2 54.48 Quite High
bradykinin 4 52.96 Quite High
Migraine 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
substance P 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ophthalmoplegia 1 95.12 Very High Very High Very High
Facial Paralysis 2 94.56 High High
Pain 45 92.64 High High
Diplopia 1 90.32 High High
Common Cold 1 89.16 High High
Miller Fisher Syndrome 4 86.36 High High
Ganglion Cysts 20 53.36 Quite High
Neuroblastoma 6 36.36 Quite Low
Hypertension 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum anti-GQ 1 b antibody was elevated.
Positive_regulation (elevated) of GQ 1
1) Confidence 0.60 Published 2001 Journal No To Shinkei Section Abstract Doc Link 11436343 Disease Relevance 0.79 Pain Relevance 0.19
Time averaged normalized sensitivities for three model outputs (cytosolic calcium, concentration of gated IP3R channels, Gq-protein activation) were computed over the parameter family as a function of P2Y and P2X activation (Fig. 6A–C).
Positive_regulation (activation) of Gq-protein
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0 Pain Relevance 0.03
Sensitivity analysis was then used, over the family of parameter sets, to estimate which parameters were critical globally and key to specific model outputs (cytosolic calcium concentration, the fraction of gated IP3R channels and Gq-protein activation).
Positive_regulation (activation) of Gq-protein
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.17 Pain Relevance 0.20

General Comments

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