INT96723

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.00
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11)
Anatomy Link Frequency
CAR 1
liver 1
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 5 99.40 Very High Very High Very High
Paracetamol 21 98.20 Very High Very High Very High
Bile 117 76.32 Quite High
headache 1 58.76 Quite High
withdrawal 1 52.60 Quite High
Inflammation 51 5.00 Very Low Very Low Very Low
agonist 27 5.00 Very Low Very Low Very Low
antagonist 21 5.00 Very Low Very Low Very Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 51 99.30 Very High Very High Very High
Nicotine Addiction 68 99.20 Very High Very High Very High
Hepatotoxicity 15 97.64 Very High Very High Very High
Pulmonary Disease 3 96.00 Very High Very High Very High
Asthma 2 93.56 High High
Injury 3 73.36 Quite High
Headache 1 58.76 Quite High
Gastrointestinal Disease 1 58.24 Quite High
Lung Cancer 9 58.16 Quite High
Disease 31 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Regulation (Role) of CYP3A associated with paracetamol, hepatotoxicity and alcohol
1) Confidence 0.44 Published 2007 Journal Drug Metab. Dispos. Section Title Doc Link 17392391 Disease Relevance 0.42 Pain Relevance 0.89
Results showed that the catalytic activity and polypeptide levels of CYP1A2, CYP2E1, and CYP3A were unchanged in the treatment groups compared to vehicle and untreated controls.
Neg (unchanged) Regulation (unchanged) of CYP3A
2) Confidence 0.42 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11437634 Disease Relevance 0.29 Pain Relevance 0.76
CYP3A genes are responsible for the initial metabolism of numerous xenobiotic chemicals, making them a first line of defense against toxic substances in the diet and environment.
Regulation (responsible) of CYP3A
3) Confidence 0.30 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.06 Pain Relevance 0.04
Immunoblot analysis of microsomal proteins showed that rutaecarpine-treatment increased the protein levels of CYP1A1 and CYP1A2 in the liver, whereas hepatic level of CYP3A-immunoreacted protein was not affected by rutaecarpine.
Neg (not) Regulation (affected) of CYP3A in liver
4) Confidence 0.26 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.12 Pain Relevance 0.06
However, constitutively active CAR (VP-CAR) transgenic mice showed only CYP2B induction; CYP3A was unchanged [Saini et al., 2004].
Neg (unchanged) Regulation (unchanged) of CYP3A in CAR associated with targeted disruption
5) Confidence 0.18 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.19 Pain Relevance 0.05
Because the CYP3A family genes produce key enzymes for the metabolism of more than 50% of prescription drugs, there has been a strong interest in understanding the mechanistic basis of CYP3A gene regulation.
Regulation (regulation) of CYP3A gene
6) Confidence 0.18 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.03
Therefore, modulation of CYP3A enzyme activity in smokers may require dose adjustment for some inhaled drugs.
Regulation (modulation) of CYP3A associated with nicotine addiction
7) Confidence 0.09 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.92 Pain Relevance 0

General Comments

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