INT96724

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 20
Disease Relevance 4.82
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11)
Anatomy Link Frequency
liver 4
hepatocytes 1
Bile 1
intestine 1
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 390 100.00 Very High Very High Very High
Versed 42 99.82 Very High Very High Very High
Paracetamol 91 99.48 Very High Very High Very High
cva 3 95.36 Very High Very High Very High
agonist 95 90.52 High High
antagonist 76 76.56 Quite High
Inflammation 171 74.68 Quite High
Antiemetics 1 25.00 Low Low
Inflammatory stimuli 10 8.96 Low Low
Crohn's disease 60 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 46 99.54 Very High Very High Very High
Injury 22 98.36 Very High Very High Very High
Hemorrhage 3 95.36 Very High Very High Very High
Targeted Disruption 197 95.32 Very High Very High Very High
Necrosis 16 95.24 Very High Very High Very High
Hepatotoxicity 31 94.88 High High
Breast Cancer 88 83.36 Quite High
Vomiting 11 79.04 Quite High
Inflammatory Bowel Disease 320 75.44 Quite High
Apoptosis 68 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation.
Gene_expression (expression) of CYP3A11 associated with toxicity and paracetamol
1) Confidence 0.77 Published 2004 Journal Toxicol. Sci. Section Abstract Doc Link 15456926 Disease Relevance 0.42 Pain Relevance 0.47
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Gene_expression (expression) of Cyp3a11 associated with paracetamol
2) Confidence 0.61 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.43 Pain Relevance 1.10
Further analysis showed that following PCN treatment, PXR-null mice had lower CYP3A11 expression, decreased NAPQI formation, and increased maintenance of hepatic glutathione content compared to wild-type mice.
Gene_expression (expression) of CYP3A11
3) Confidence 0.60 Published 2004 Journal Toxicol. Sci. Section Abstract Doc Link 15456926 Disease Relevance 0.43 Pain Relevance 0.50
Results showed that the catalytic activity and polypeptide levels of CYP1A2, CYP2E1, and CYP3A were unchanged in the treatment groups compared to vehicle and untreated controls.
Gene_expression (levels) of CYP3A
4) Confidence 0.56 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11437634 Disease Relevance 0.29 Pain Relevance 0.76
In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.
Gene_expression (expression) of CYP3A11 in hepatocytes
5) Confidence 0.54 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.17 Pain Relevance 0.29
Finally, when given 12 h before APAP challenge, IL-1 alpha repressed the intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, eventually reducing APAP-induced liver injury, along with reduction in APAP adducts.
Gene_expression (expression) of CYP3A11 in liver associated with paracetamol and injury
6) Confidence 0.52 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.45 Pain Relevance 1.08
By contrast, the intranuclear amount of p65 of NF-kappaB, which can suppress the gene expression of CYP1A2, CYP2E1, and CYP3A11, was higher in untreated IL-1ra KO than WT mice.
Gene_expression (expression) of CYP3A11
7) Confidence 0.52 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.44 Pain Relevance 1.21
Moreover, the amounts of a major APAP adduct (selenium-binding protein), an indicator of NAPQI generation from APAP, was significantly lower in IL-1ra KO mice than WT mice with depressed intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, the enzymes crucially involved in NAPQI generation from APAP.
Gene_expression (expression) of CYP3A11 associated with paracetamol
8) Confidence 0.52 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.21 Pain Relevance 1.05
The relatively modest differences in the response of SXR harboring non-synonymous SNPs to ligands suggest that these SNPs are probably not the sole factors mediating variations in CYP3A expression.
Gene_expression (expression) of CYP3A
9) Confidence 0.51 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.26 Pain Relevance 0.08
Variation in CYP3A expression may lead to important differences in drug metabolism, leading to clinically significant differences in drug toxicities and response.
Gene_expression (expression) of CYP3A associated with toxicity
10) Confidence 0.51 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.18 Pain Relevance 0
Activation of SXR by these sterol compounds induces CYP3A expression and provides an alternative pathway for sterol clearance in CYP27A1 null mice [Dussault et al., 2003; Goodwin et al., 2003].
Gene_expression (expression) of CYP3A
11) Confidence 0.51 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.11 Pain Relevance 0.37
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Gene_expression (expression) of CYP3A11 in intestine
12) Confidence 0.51 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
It is well known that drugs capable of inducing expression of CYP3A genes are likely to lead to interactions with other drugs.
Gene_expression (expression) of CYP3A
13) Confidence 0.51 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Many EDCs including bisphenol-A, organochlorine and organophosphate pesticides, alkylphenols, phthalates and PCBs have been shown to upregulate CYP3A expression and activate SXR [Coumoul et al., 2002; Hurst and Waxman, 2004; Jacobs et al., 2005; Lemaire et al., 2004; Masuyama et al., 2000; Tabb et al., 2004; Takeshita et al., 2001].
Gene_expression (expression) of CYP3A
14) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Because the CYP3A family genes produce key enzymes for the metabolism of more than 50% of prescription drugs, there has been a strong interest in understanding the mechanistic basis of CYP3A gene regulation.
Gene_expression (produce) of CYP3A
15) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.03
The levels of CYP3A enzymes show considerable sexual dimorphisms and variation in levels and function among individuals in the population [Gonzalez, 1992].
Gene_expression (levels) of CYP3A
16) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0
Bile acid induced activation of SXR also upregulates the expression of genes involved in bile acid metabolism and transport, such as MRP2, OATP2 and CYP3A [Frank et al., 2005; Guo et al., 2003; Kast et al., 2002; Kullak-Ublick, 2003].
Gene_expression (expression) of CYP3A in Bile associated with bile
17) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.24 Pain Relevance 0.44
The NADH-mediated in vitro turnovers of the probe drugs
chlorzoxazone (Cyp2e1), metoprolol (Cyp2d), midazolam (Cyp2c, Cyp3a),
tolbutamide (Cyp2c), and phenacetin (Cyp1a)
(37–41)
were also examined with liver microsomes from both HBN and wild-type mice.

Spec (examined) Gene_expression (examined) of Cyp3a in liver associated with versed
18) Confidence 0.39 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0.12
No differences in the upregulation of cytochrome P450 gene expression (CYP1A2, CYP2B10, CYP3A11 and CYP2E1) were seen following PB or TCPOBOP treatment between NCoA6(PRIP)+/+ or liver NCoA6(PRIP)-/- conditional knockout mice.
Gene_expression (expression) of CYP3A11 in liver associated with targeted disruption
19) Confidence 0.32 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.72 Pain Relevance 0.15
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Gene_expression (expression) of CYP3A11 in liver
20) Confidence 0.17 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05

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