INT96740

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.96
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
neurons 2
satellite cells 1
bladder 1
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 196 100.00 Very High Very High Very High
dorsal root ganglion 52 98.64 Very High Very High Very High
substance P 3 97.48 Very High Very High Very High
Demyelination 49 95.04 Very High Very High Very High
cytokine 21 93.36 High High
qutenza 14 91.04 High High
bradykinin 2 90.24 High High
MU agonist 2 84.68 Quite High
allodynia 2 84.48 Quite High
Enkephalin 1 82.84 Quite High
Disease Link Frequency Relevance Heat
Injury 56 99.14 Very High Very High Very High
Ganglion Cysts 53 98.64 Very High Very High Very High
Demyelinating Disease 51 95.04 Very High Very High Very High
Nervous System Injury 36 88.64 High High
Myocardial Infarction 50 87.20 High High
Neuropathic Pain 35 84.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 26 81.16 Quite High
Infarction 31 79.28 Quite High
Pain 37 75.00 Quite High
Nociception 23 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus our findings indicate that bladder injury produced by CYP-treatment results in mRNA upregulation of the chemokine receptor CXCR4 and increased protein levels of its cognate ligand, SDF-1.
Transcription (upregulation) of CXCR4 in bladder associated with chemokine and injury
1) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.30 Pain Relevance 0.25
Notably satellite cells under these conditions lacked both CXCR4 mRNA transcripts and protein expression (Fig. 4E, F).
Transcription (expression) of CXCR4 mRNA in satellite cells
2) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.29 Pain Relevance 0.18
Despite little change in non-neuronal cells, there was an increase in the number of neurons expressing CXCR4 mRNA transcripts by POD14 in the lumbar DRG ipsilateral to the nerve lesion (Fig. 4D).
Transcription (transcripts) of CXCR4 mRNA in neurons
3) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.44 Pain Relevance 0.44
RT-PCR analysis confirmed the expression of CXCR4, CX3CR1, CCR4, and CCR5 mRNAs in DRG neurons.
Transcription (expression) of CXCR4 in neurons associated with dorsal root ganglion
4) Confidence 0.39 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438578 Disease Relevance 1.34 Pain Relevance 1.38
And CXCR4 mRNA expression was greater than c-Kit mRNA expression in the infarcted area of AdV.SDF-1 group (Fig. 2a, b).
Transcription (expression) of CXCR4
5) Confidence 0.25 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.59 Pain Relevance 0
Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein.
Transcription (expression) of CXCR4 associated with chemokine
6) Confidence 0.11 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.88

General Comments

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