INT96741

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 62
Total Number 65
Disease Relevance 32.30
Pain Relevance 22.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
bladder 13
neurons 7
neuronal 5
bone marrow 2
epithelial cells 2
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1986 100.00 Very High Very High Very High
Inflammation 882 99.90 Very High Very High Very High
Opioid 20 99.84 Very High Very High Very High
opioid receptor 18 99.80 Very High Very High Very High
Morphine 6 99.80 Very High Very High Very High
MU agonist 9 99.76 Very High Very High Very High
dorsal root ganglion 616 99.68 Very High Very High Very High
Demyelination 400 99.64 Very High Very High Very High
substance P 29 99.48 Very High Very High Very High
Substantia nigra 5 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 302 100.00 Very High Very High Very High
INFLAMMATION 952 99.90 Very High Very High Very High
Ganglion Cysts 624 99.68 Very High Very High Very High
Infarction 125 99.68 Very High Very High Very High
Demyelinating Disease 421 99.64 Very High Very High Very High
Injury 678 99.54 Very High Very High Very High
Cystitis 425 98.92 Very High Very High Very High
Bladder Cancer 75 98.84 Very High Very High Very High
Lymphatic System Cancer 122 98.44 Very High Very High Very High
Infection 59 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat substantia nigra (SN), Chemokine (CXC motif) receptor 4 (CXCR4) for the chemokine stromal cell-derived factor (SDF)-1alpha is expressed on dopaminergic (DA) neurones, but also on non-DA cells, suggesting presynaptic actions.
Gene_expression (expressed) of CXCR4 in substantia nigra associated with chemokine and substantia nigra
1) Confidence 0.78 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16476083 Disease Relevance 0 Pain Relevance 0.48
Bladder CXCR4 expression (real-time RTC-PCR) and protein levels (Western blotting) were examined.
Gene_expression (expression) of CXCR4 in Bladder
2) Confidence 0.76 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.40 Pain Relevance 0.21
Recent evidence has clearly shown expression of CXCR4 (and other chemokine receptors) on dorsal root ganglion (DRG) neurons [34].
Gene_expression (expression) of CXCR4 in neurons associated with ganglion cysts, dorsal root ganglion and chemokine
3) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.17 Pain Relevance 0.69
Also, CXCR4 (and other chemokine receptors and chemokines) expression was reported in DRG neurons following a rodent model of persistent neuropathy [35], [36].
Gene_expression (expression) of CXCR4 in neurons associated with dorsal root ganglion, chemokine and neuropathic pain
4) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.27 Pain Relevance 0.79
CXCR4 and SDF-1 are also expressed in human intestinal epithelial cells where recent evidence indicates it participates in epithelial repair following injury and maintaining mucosal barrier integrity [31], [32].
Gene_expression (expressed) of CXCR4 in epithelial cells associated with injury
5) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.71 Pain Relevance 0.31
Bladder CXCR4 mRNA expression, Western blotting and CXCR4-MIF co-immunoprecipitation
Gene_expression (expression) of CXCR4 mRNA in Bladder
6) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Bladder CXCR4 mRNA expression, Western blotting and CXCR4-MIF co-immunoprecipitation
Gene_expression (expression) of CXCR4 in Bladder
7) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
A similar discrepancy between CXCR4 mRNA expression and protein levels has been reported in the rat neurons and shown to reflect activation, increased internalization and degradation of CXCR4 receptors [27] .
Gene_expression (expression) of CXCR4 mRNA in neurons
8) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.27 Pain Relevance 0.07
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
Gene_expression (expression) of CXCR4 in bladder
9) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
There is also evidence of CXCR4 mRNA expression in other areas of the human urogenital system (e.g. urethra, cervix) [28].
Gene_expression (expression) of CXCR4 mRNA in cervix associated with stress incontinence
10) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.34 Pain Relevance 0
The results from the present study demonstrate that CXCR4, a chemokine cell-surface receptor, is constitutively expressed in normal rat urothelium localized to basal and intermediate cells.
Gene_expression (expressed) of CXCR4 associated with chemokine
11) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.18 Pain Relevance 0.10
Our results show that both CXCR4 and SDF-1 are constitutively expressed in normal rat bladder and upregulated during CYP-induced cystitis.
Gene_expression (expressed) of CXCR4 in bladder associated with cystitis
12) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.73 Pain Relevance 0.15
CXCR4 is expressed by normal urothelium and may be associated with bladder cancer [20], [21].
Gene_expression (expressed) of CXCR4 in bladder associated with bladder cancer
13) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.27
CXCR4 mRNA expression in normal human urothelium, bladder cancer and also bladder cancer cell lines (J82 and T24) was previously reported [20] .
Gene_expression (expression) of CXCR4 mRNA in bladder associated with bladder cancer
14) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.38 Pain Relevance 0.03
Total RNA was isolated from bladder tissues using Trizol (Invitrogen) and CXCR4 (SuperArray primer; PPR06440A; SABiosciences, Frederick, MD, USA) and 18S rRNA (control; SuperArray: PPR57734E) gene expression was determined by Real-time RT-PCR (Opticon, Bio-Rad, Hercula, CA, USA) using SYBR Green incorporation and the ??
Gene_expression (expression) of CXCR4 in bladder
15) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
In summary, the chemokine receptor CXCR4 is constitutively expressed in rat urothelium (in basal and intermediate cells) while CYP-induced bladder inflammation resulted in upregulation of CXCR4 and immunostaining of superficial cells (previously devoid of CXCR4).
Gene_expression (expressed) of CXCR4 in bladder associated with chemokine and inflammation
16) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.82 Pain Relevance 0.71
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Gene_expression (levels) of CXCR4 protein
17) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
CYP treatment (aside from producing bladder inflammation and urothelial hyperplasia, well-described effects of cyclophosphamide in the bladder [24], [25]) also resulted in up-regulation of bladder CXCR4 mRNA and redistribution of CXCR4 to the entire urothelial area (including apical area of superficial cells previously devoid of CXCR4; Fig. 2D).
Gene_expression (redistribution) of CXCR4 in bladder associated with inflammation and hyperplasia
18) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.19 Pain Relevance 0.09
In this model then, chemokines and chemokine receptors (and particularly CXCR4/SDF-1) may represent an autocrine/paracrine loop that helps maintain mucosal barrier integrity and repair as well as regulating mucosal pathogenesis (including chronic inflammation as seen inflammatory bowel disease and progression to colon cancer) [33] .
Gene_expression (/) of CXCR4 in bowel associated with chemokine, inflammation and colon cancer
19) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.92 Pain Relevance 0.39
200; goat-polyclonal; Novus Biological, Littleton, CO, USA; #NB100-1789) and CXCR4 antisera (1?
Gene_expression (antisera) of CXCR4
20) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.15 Pain Relevance 0

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