INT96743

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Context Info
Confidence 0.54
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.72
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
nerve 1
neurons 1
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 6 99.60 Very High Very High Very High
chemokine 217 98.16 Very High Very High Very High
substance P 2 97.48 Very High Very High Very High
qutenza 12 91.04 High High
bradykinin 3 90.24 High High
allodynia 3 86.40 High High
Demyelination 94 85.96 High High
Sciatic nerve 30 77.12 Quite High
Pain 33 76.96 Quite High
Stimulus evoked pain 9 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.60 Very High Very High Very High
Nervous System Injury 56 96.56 Very High Very High Very High
Injury 28 92.64 High High
Neuropathic Pain 35 86.40 High High
Demyelinating Disease 96 85.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 81.16 Quite High
Pain 55 75.00 Quite High
Nociception 30 75.00 Quite High
Hypersensitivity 9 75.00 Quite High
Peripheral Neuropathy 3 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike CXCR3 expression, lumbar DRG in naïve (data not shown) and sham-treated rats at POD14 (Fig. 5B) were devoid of CCR5 mRNA transcripts.
Transcription (transcripts) of CCR5 mRNA
1) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.68 Pain Relevance 0.39
RT-PCR analysis confirmed the expression of CXCR4, CX3CR1, CCR4, and CCR5 mRNAs in DRG neurons.
Transcription (expression) of CCR5 in neurons associated with dorsal root ganglion
2) Confidence 0.52 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438578 Disease Relevance 1.35 Pain Relevance 1.39
As with CCR2 expression in sensory neurons, CCR5 mRNA transcript levels were strongly increased in many sensory neurons ipsilateral and contralateral to the nerve injury at POD14 (Fig. 5D).
Transcription (levels) of CCR5 mRNA in nerve associated with nervous system injury
3) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.69 Pain Relevance 0.40

General Comments

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