INT96744

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.92
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
neurons 4
bladder 4
sensory neurons 2
monocytes 2
DRG 2
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 7 99.98 Very High Very High Very High
Morphine 3 99.98 Very High Very High Very High
MU agonist 4 99.96 Very High Very High Very High
chemokine 358 99.72 Very High Very High Very High
dorsal root ganglion 148 99.56 Very High Very High Very High
qutenza 28 98.80 Very High Very High Very High
bradykinin 2 98.00 Very High Very High Very High
antagonist 71 97.40 Very High Very High Very High
peripheral neuropathy 16 97.16 Very High Very High Very High
Opioid 10 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 148 99.98 Very High Very High Very High
Ganglion Cysts 149 99.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 88 98.28 Very High Very High Very High
Infection 16 98.04 Very High Very High Very High
Peripheral Neuropathy 17 97.16 Very High Very High Very High
Neuropathic Pain 70 95.12 Very High Very High Very High
Cicatrix 8 92.60 High High
Sprains And Strains 2 92.24 High High
Demyelinating Disease 57 92.16 High High
Fibrosis 4 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
Positive_regulation (upregulated) of Gene_expression (expression) of CXCR4 in bladder
1) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Injury induced alteration of CXCR4 mRNA and protein expression in lumbar DRG
Positive_regulation (induced) of Gene_expression (expression) of CXCR4 mRNA associated with dorsal root ganglion and injury
2) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.50 Pain Relevance 0.36
The combination of perineural gp120/hCD4 treatment with ddC produced increased neuronal expression of both CXCR4 and CCR2 receptors together with their respective ligands, SDF1 and MCP1 in rather distinct subpopulations of sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 in sensory neurons
3) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.57 Pain Relevance 0.42
Upregulated CXCR4 expression, however, is primarily restricted to neurons making them a potential target for the release of SDF-1 from glia.
Positive_regulation (Upregulated) of Gene_expression (expression) of CXCR4 in neurons
4) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.54 Pain Relevance 0.61
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Neg (not) Positive_regulation (increased) of Gene_expression (levels) of CXCR4 protein
5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Neg (not) Positive_regulation (result) of Gene_expression (levels) of CXCR4 protein
6) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
Cyclophosphamide treatment caused: 1) significant redistribution of CXCR4 immunostaining to all urothelial layers (especially apical surface of superficial cells) and increased bladder CXCR4 expression; 2) increased urine MIF with decreased bladder MIF; 3) increased bladder SDF-1; 4) increased CXCR4-MIF associations.


Positive_regulation (increased) of Gene_expression (expression) of CXCR4 in bladder
7) Confidence 0.46 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.41 Pain Relevance 0.16
However, when both treatments were combined, rather than observing the increased expression of either MCP1/CCR2 or SDF1/CXCR4, both chemokine signaling systems were upregulated and this was observed to occur mostly in neurons.
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 in neurons associated with chemokine
8) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.86 Pain Relevance 0.39
Immunohistochemical studies demonstrated the expression of the CXCR4 and CCR4 chemokine receptors on populations of DRG neurons that also expressed substance P and the VR1 vanilloid receptor.
Positive_regulation (demonstrated) of Gene_expression (expression) of CXCR4 in DRG associated with dorsal root ganglion, chemokine and substance p
9) Confidence 0.36 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438578 Disease Relevance 1.36 Pain Relevance 1.24
This is confirmed by further studies showing the role of SCF in the induction of the expression of CXCR4 on human CD34+ cells resulting in an increase in their migration in response to SDF-1116.
Positive_regulation (induction) of Gene_expression (expression) of CXCR4
10) Confidence 0.32 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.15 Pain Relevance 0.05
We have also found that morphine enhances CXCR4 and CCR5 expression and subsequently increases both X4 and R5 HIV-1 infection.
Positive_regulation (enhances) of Gene_expression (expression) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection, infection and morphine
11) Confidence 0.22 Published 2003 Journal Virology Section Abstract Doc Link 12726730 Disease Relevance 0.99 Pain Relevance 0.82
In addition, in the setting of liver injury, MMP-9 is associated with increased CXCR4 expression on stem cells, and MMP inhibitors reduce homing of these cells to the liver [42, 43].
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 in stem cells associated with injury
12) Confidence 0.22 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 1.29 Pain Relevance 0.08
Our results show that DAMGO, a selective mu-opioid agonist, increases CXCR4 and CCR5 expression in both CD3(+) lymphoblasts and CD14(+) monocytes three- to fivefold.
Positive_regulation (increases) of Gene_expression (expression) of CXCR4 in monocytes associated with mu agonist
13) Confidence 0.16 Published 2003 Journal Virology Section Abstract Doc Link 12726730 Disease Relevance 0.94 Pain Relevance 0.82
Previously, our laboratory reported that activation of the mu-opioid receptor induced the expression of CCL2, CCL5, and CXCL10, as well as CCR5 and CXCR4.
Positive_regulation (induced) of Gene_expression (expression) of CXCR4 associated with opioid receptor
14) Confidence 0.11 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.63

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