INT96755

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Context Info
Confidence 0.73
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.00
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 2
caudate putamen 1
bladder 1
basal ganglia 1
frontal cortex 1
Cnrip1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 28 100.00 Very High Very High Very High
Opioid 20 100.00 Very High Very High Very High
agonist 38 99.66 Very High Very High Very High
Morphine 8 99.52 Very High Very High Very High
Nucleus accumbens 7 96.92 Very High Very High Very High
Hippocampus 1 94.68 High High
amygdala 7 93.84 High High
withdrawal 4 93.40 High High
opiate 4 92.76 High High
Ventral tegmentum 5 92.24 High High
Disease Link Frequency Relevance Heat
Overactive Bladder 25 99.64 Very High Very High Very High
Urological Neuroanatomy 4 98.76 Very High Very High Very High
Obesity 5 96.88 Very High Very High Very High
Multiple Sclerosis 14 95.92 Very High Very High Very High
Opiate Addiction 6 93.76 High High
Autoimmune Disease 1 63.72 Quite High
Tremor 1 61.96 Quite High
Pain 26 61.64 Quite High
Spasticity 2 61.40 Quite High
Nociception 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we report on the application of two specific polyclonal antibodies to different intracellular domains of the CB1 cannabinoid receptor to define the expression of the neural CB1 cannabinoid receptor at the histochemical level in frontal cortex and related limbic areas of the obese Zucker rats.
Gene_expression (expression) of CB1 cannabinoid receptor in frontal cortex associated with cannabinoid receptor, obesity and urological neuroanatomy
1) Confidence 0.73 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.49 Pain Relevance 0.30
Rolipram attenuated clinical decline, reduced motor inhibition, and normalized CB1 receptor gene expression in the basal ganglia.
Gene_expression (expression) of CB1 receptor gene in basal ganglia
2) Confidence 0.70 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 16242629 Disease Relevance 0.98 Pain Relevance 0.60
This study examines the effect of intravenous self-administration (SA) of either heroin or the cannabinoid receptor agonist WIN 55,212-2 on levels and functionality of mu-opioid (MOR) and CB1-cannabinoid receptors (CB1R) in reward-related brain areas, such as the prefrontal cortex (PFC), nucleus accumbens (NAc), caudate putamen (CP), hippocampus (Hippo), amygdala (Amy), hypothalamus (Hypo) and ventral tegmental area (VTA). [3H]DAMGO and [3H]CP-55,940 autoradiography and agonist-stimulated [35S]GTPgammaS binding were performed on brain sections of rats firmly self-administering heroin or WIN 55,212-2.
Gene_expression (levels) of CB1-cannabinoid in NAc associated with ventral tegmentum, nucleus accumbens, cannabinoid receptor, agonist, hippocampus, amygdala and opioid
3) Confidence 0.25 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17419755 Disease Relevance 0 Pain Relevance 0.92
These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum.
Gene_expression (expression) of CB1 receptor mRNA in nucleus accumbens associated with nucleus accumbens and morphine
4) Confidence 0.16 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438610 Disease Relevance 0.18 Pain Relevance 1.50
These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum.
Gene_expression (expression) of CB1 receptor mRNA in caudate putamen associated with nucleus accumbens and morphine
5) Confidence 0.05 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438610 Disease Relevance 0.18 Pain Relevance 1.50
The co-expression of VAChT and CB receptor, and effects by CP55940, on nerve mediated contractions suggest a CB2 receptor mediated modulatory effect on cholinergic nerve activity in bladder.[34]
Gene_expression (expression) of CB receptor in bladder
6) Confidence 0.01 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.18 Pain Relevance 0.19

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