INT96762

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 5.77
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAI1) cytoplasm (RAI1)
Anatomy Link Frequency
spinal cord 2
cortex 1
blood cell 1
RAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 15 99.52 Very High Very High Very High
depression 3 92.76 High High
Spontaneous pain 3 88.32 High High
Pain 29 86.84 High High
Glutamate receptor 15 79.52 Quite High
Opioid 12 75.00 Quite High
antagonist 10 55.56 Quite High
Enkephalin 3 25.00 Low Low
agonist 3 25.00 Low Low
aspirin 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 189 100.00 Very High Very High Very High
Coronary Artery Disease 264 99.16 Very High Very High Very High
Rheumatoid Arthritis 76 99.06 Very High Very High Very High
Anxiety Disorder 4 93.24 High High
Depression 3 92.76 High High
Injury 10 90.12 High High
Attention Deficit Hyperactivity Disorder 1 88.72 High High
Pain 19 87.36 High High
Language Development Disorders 1 86.20 High High
Frailty 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This resulted in the insertion of the MDLS region into the middle SMS-REP/LCR17pB block, loss of the subtelomeric region 17p13.3, and part of 17p12, and duplication of the CMT1A and SMS regions.
Gene_expression (duplication) of SMS associated with syndrome
1) Confidence 0.56 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.30 Pain Relevance 0
An apparent underestimation of the full complexity of CCRs is well demonstrated in patient 1, in whom a complex karyotype was identified, including an inverted insertion of the MDLS region into the middle SMS-REP/LCR17pB block, two microdeletions (terminal and interstitial in 17p12) and a microduplication involving both SMS and CMT1A chromosome regions.
Gene_expression (microduplication) of SMS associated with syndrome
2) Confidence 0.56 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.40 Pain Relevance 0
This resulted in the insertion of the MDLS region into the middle SMS-REP/LCR17pB block, loss of the subtelomeric region 17p13.3, and part of 17p12, and duplication of the CMT1A and SMS regions.
Gene_expression (duplication) of SMS associated with syndrome
3) Confidence 0.56 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.30 Pain Relevance 0
An apparent underestimation of the full complexity of CCRs is well demonstrated in patient 1, in whom a complex karyotype was identified, including an inverted insertion of the MDLS region into the middle SMS-REP/LCR17pB block, two microdeletions (terminal and interstitial in 17p12) and a microduplication involving both SMS and CMT1A chromosome regions.
Gene_expression (insertion) of SMS associated with syndrome
4) Confidence 0.56 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.41 Pain Relevance 0
RAI1 was also expressed at significantly higher levels in CAD patients (FDR = 4.3%), and indeed is located in the middle of the 303 gene cluster in Figure 2.
Gene_expression (expressed) of RAI1 associated with coronary artery disease
5) Confidence 0.56 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.56 Pain Relevance 0
Next, we compared the expression of RAI1 in CD34+ cells from CAD patients and controls to the different peripheral blood cell types, depicted in Figure 4B.
Gene_expression (expression) of RAI1 in blood cell associated with coronary artery disease
6) Confidence 0.56 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.68 Pain Relevance 0
We identified three RA-related genes that showed a highly correlated expression with RAI1, but did not reach statistical significance in the SAM list of 303 genes at an FDR of 5%.
Gene_expression (expression) of RAI1 associated with rheumatoid arthritis
7) Confidence 0.56 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.51 Pain Relevance 0
Increased expression of RAI1 is restricted to CD34+ cells from CAD patients, suggesting an actively induced expression.


Gene_expression (expression) of RAI1 associated with coronary artery disease
8) Confidence 0.56 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.65 Pain Relevance 0
Thus, a total of 112 primary caregivers (i.e., parents) of individuals diagnosed with SMS responded to online questionnaires to assess demographic and psychosocial factors, such as perceptions of child health vulnerability, benefit finding, sleep behaviors, anxiety and depression symptomatology, and caregiver satisfaction and self-efficacy, which may be related to caregiver well-being.
Gene_expression (diagnosed) of SMS associated with depression, syndrome and anxiety disorder
9) Confidence 0.35 Published 2010 Journal J Genet Couns Section Abstract Doc Link 20151318 Disease Relevance 1.04 Pain Relevance 0.16
NBQX did not affect quisqualic acid-induced spinal or cortical expression of preprodynorphin or preproenkephalin except for a significant decrease in preproenkephalin expression in the spinal cord.
Gene_expression (expression) of acid-induced in spinal cord associated with spinal cord
10) Confidence 0.01 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440816 Disease Relevance 0.30 Pain Relevance 0.58
In contrast, AIDA significantly decreases quisqualic acid-induced preprodynorphin and preproenkephalin expression within the spinal cord and cortex.
Gene_expression (expression) of acid-induced in spinal cord associated with spinal cord
11) Confidence 0.01 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440816 Disease Relevance 0.31 Pain Relevance 0.71
In contrast, AIDA significantly decreases quisqualic acid-induced preprodynorphin and preproenkephalin expression within the spinal cord and cortex.
Gene_expression (expression) of acid-induced in cortex associated with spinal cord
12) Confidence 0.00 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440816 Disease Relevance 0.31 Pain Relevance 0.71

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