INT96763

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.08
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
paw 4
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 8 100.00 Very High Very High Very High
Hyperalgesia 12 98.12 Very High Very High Very High
Inflammation 24 95.56 Very High Very High Very High
Spinal cord 8 93.36 High High
Kinase C 10 90.88 High High
nociceptor 6 65.48 Quite High
Dorsal horn neuron 2 63.36 Quite High
Thermal hyperalgesia 2 26.16 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 14 98.12 Very High Very High Very High
INFLAMMATION 18 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, on the side of lumbar cord ipsilateral to the inflamed paw, the activity of membrane-associated protein kinase CbetaII was increased following the same time-course as the paw withdrawal latency decrease, suggesting an increased translocation of protein kinase Cbetall to the membrane related to behavioral hyperalgesia.
Positive_regulation (increased) of Localization (translocation) of protein kinase in paw associated with hyperalgesia and withdrawal
1) Confidence 0.39 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.02 Pain Relevance 1.30
Importantly, on the side of lumbar cord ipsilateral to the inflamed paw, the activity of membrane-associated protein kinase CbetaII was increased following the same time-course as the paw withdrawal latency decrease, suggesting an increased translocation of protein kinase Cbetall to the membrane related to behavioral hyperalgesia.
Positive_regulation (increased) of Localization (translocation) of protein kinase in paw associated with hyperalgesia and withdrawal
2) Confidence 0.24 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.06 Pain Relevance 1.35

General Comments

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