INT96764

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 16.55
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
SH-SY5Y 4
neural 4
monocytes 4
corpus 2
brain 2
SOD1 (Homo sapiens)
SOD1 - G93A (6)
Pain Link Frequency Relevance Heat
Hippocampus 96 99.60 Very High Very High Very High
long-term potentiation 8 98.52 Very High Very High Very High
Spinal cord 20 97.44 Very High Very High Very High
agonist 90 97.24 Very High Very High Very High
medulla 8 96.80 Very High Very High Very High
diclofenac 12 93.40 High High
Inflammation 122 80.48 Quite High
Central nervous system 24 80.40 Quite High
Inflammatory response 9 80.36 Quite High
cytokine 70 79.44 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 203 100.00 Very High Very High Very High
Targeted Disruption 117 100.00 Very High Very High Very High
Injury 206 99.84 Very High Very High Very High
Wound Healing 58 99.60 Very High Very High Very High
Stress 350 99.54 Very High Very High Very High
Liver Disease 3 99.46 Very High Very High Very High
Down Syndrome 88 98.96 Very High Very High Very High
Diabetes Mellitus 19 98.92 Very High Very High Very High
Shock 1 98.44 Very High Very High Very High
Motor Neuron Diseases 302 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A transgenic mouse overexpressing human SOD1 was created and may serve as a model for neurodegenerative disorders [9].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SOD1 associated with targeted disruption and neurodegenerative disease
1) Confidence 0.61 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.81 Pain Relevance 0.17
It has been reported that hippocampal slices from transgenic mice overexpressing SOD1 (SOD1-TG) were found to exhibit deficient long-term potentiation, a putative neural substrate of memory, and hippocampal-mediated memory function [10].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SOD1 in neural associated with targeted disruption and long-term potentiation
2) Confidence 0.61 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.77 Pain Relevance 0.18
These results indicate that changes in the SOD1 variants' properties, specifically increases in hydrophobicity and propensity to lose ?
Positive_regulation (increases) of Gene_expression (variants) of SOD1
3) Confidence 0.50 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0 Pain Relevance 0
In addition to their greater vulnerability to bacterial hemolysins, increased susceptibility of neurons expressing the G93A mutant in their SOD1 to the attack of activated immune cells may be the pathophysiological basis of the vulnerability of the nervous system of patients with motor neuron disease to systemic infections.
Positive_regulation (increased) of Gene_expression (expressing) of SOD1 (G93A) in nervous system associated with infection and motor neuron diseases
4) Confidence 0.47 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 1.18 Pain Relevance 0.15
A dose-dependent increase in MDA levels and SOD activity was also observed, which indicated a link between oxidative stress and nephrotoxicity.
Positive_regulation (increase) of Gene_expression (levels) of SOD associated with nephrotoxicity and stress
5) Confidence 0.47 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11440826 Disease Relevance 1.59 Pain Relevance 0.24
Levels of Cu/Zn superoxide dismutase were increased in wound tissue from mice treated with 6, 8 dithio-UA compared to vehicle-treated mice, suggesting that the UA analog enhances endogenous cellular antioxidant defenses.
Positive_regulation (increased) of Gene_expression (Levels) of Cu/Zn superoxide dismutase associated with injury
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2850366 Disease Relevance 0.94 Pain Relevance 0.03
SOD1-TGs, transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1

Competing interests

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Cu/Zn-superoxide dismutase associated with targeted disruption
7) Confidence 0.44 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.36 Pain Relevance 0
It has been reported that hippocampal slices from transgenic mice overexpressing SOD1 (SOD1-TG) were found to exhibit deficient long-term potentiation, a putative neural substrate of memory, and hippocampal-mediated memory function [10].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SOD1 in neural associated with targeted disruption and long-term potentiation
8) Confidence 0.44 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.77 Pain Relevance 0.18
SOD1-TGs, transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1

Competing interests

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SOD1 associated with targeted disruption
9) Confidence 0.44 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.36 Pain Relevance 0
In an in-vitro model of amyotrophic lateral sclerosis we showed that SH-SY5Y neuroblastoma cells transfected with the G93A mutant of SOD1 typical for familial ALS (G93A-SOD1) are more vulnerable to infectious stimuli than neuroblastoma cells overexpressing normal SOD1.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SOD1 in SH-SY5Y associated with neuroblastoma and motor neuron diseases
10) Confidence 0.43 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.85 Pain Relevance 0.05
The in vivo transfection of the pSOD-loaded HSA NP was studied in mouse eye.
Positive_regulation (transfection) of Gene_expression (transfection) of pSOD-loaded in eye
11) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Twenty-four hours post seeding, cells were transfected for 6 h with pSOD, pSOD-encapsulated in HSA NP or pSOD with 37.5 ?
Positive_regulation (transfected) of Gene_expression (transfected) of pSOD
12) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Influence of pSOD encapsulation towards zeta potential was also reflected by the higher zeta potential of pSOD-loaded NP relative to blank NP.
Positive_regulation (potential) of Gene_expression (relative) of pSOD-loaded
13) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
In western blot analysis, GFP-SOD transfected N/N1003A lens epithelial cells were used as positive controls.
Positive_regulation (transfected) of Gene_expression (transfected) of SOD in epithelial cells
14) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0.06
l of FITC-labeled pSOD-HSA NP suspension (0.1 mg/ml) together with 100 ?
Positive_regulation (-) of Gene_expression (suspension) of pSOD
15) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Lyophilized blank HSA NP (prepared following the same protocols as pSOD-HSA NP, without the addition of pSOD) were dispersed to concentrations ranging from 5 to 5000 ?
Positive_regulation (following) of Gene_expression (addition) of pSOD
16) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Increased vulnerability of neuroblastoma cells transfected with G93A-SOD1 to the attack of monocytes stimulated with the Toll-like receptor-2 agonist Pam3CSK4
Positive_regulation (Increased) of Gene_expression (transfected) of G93A-SOD1 (G93A) in monocytes associated with neuroblastoma and agonist
17) Confidence 0.41 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.28 Pain Relevance 0.09
Impair</span>ed ability of <span style="background-color:#FFA07A">neuroblastoma cells transfected with G93A-SOD1 to cope with the pneumolysin-induced calcium influx
Positive_regulation (induced) of Gene_expression (transfected) of G93A-SOD1 (G93A) associated with neuroblastoma
18) Confidence 0.41 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.74 Pain Relevance 0
Impair</span>ed ability of <span style="background-color:#FFA07A">neuroblastoma cells transfected with G93A-SOD1 to cope with the pneumolysin-induced calcium influx
Positive_regulation (transfected) of Gene_expression (transfected) of G93A-SOD1 (G93A) associated with neuroblastoma
19) Confidence 0.41 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.74 Pain Relevance 0
Increased vulnerability of neuroblastoma cells transfected with G93A-SOD1 to the attack of monocytes stimulated with the Toll-like receptor-2 agonist Pam3CSK4
Positive_regulation (transfected) of Gene_expression (transfected) of G93A-SOD1 (G93A) in monocytes associated with neuroblastoma and agonist
20) Confidence 0.41 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 0.28 Pain Relevance 0.09

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