INT96772

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Context Info
Confidence 0.66
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.44
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
adipocytes 2
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 79.52 Quite High
Catecholamine 3 79.12 Quite High
Dopamine 4 68.48 Quite High
cINOD 1 34.80 Quite Low
Arthritis 1 32.16 Quite Low
Central nervous system 6 15.16 Low Low
Neurotransmitter 1 7.68 Low Low
imagery 27 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
magnetoencephalography 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Disease 21 99.92 Very High Very High Very High
Obesity 102 99.84 Very High Very High Very High
Disease 43 99.50 Very High Very High Very High
Diabetes Mellitus 36 99.24 Very High Very High Very High
Hypertension 26 98.84 Very High Very High Very High
Alzheimer's Dementia 2 97.92 Very High Very High Very High
Cognitive Disorder 75 97.64 Very High Very High Very High
Syndrome 2 97.60 Very High Very High Very High
Stroke 51 97.12 Very High Very High Very High
Dementia 81 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Bernier et al, in collaboration with our laboratory, has demonstrated that overexpression of apoE in adipocytes reduces differentiation as well as the accumulation of cholesterol and triglycerides in these cells [7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of apoE in adipocytes associated with obesity
1) Confidence 0.66 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.60 Pain Relevance 0
Four risk factors for AD are firmly established: increasing age, the presence of the apolipoproteinE-epsilon4 allele, familial aggregation of cases, and Down's syndrome.
Positive_regulation (increasing) of Gene_expression (presence) of apolipoproteinE associated with syndrome and disease
2) Confidence 0.49 Published 2001 Journal Aging (Milano) Section Abstract Doc Link 11442298 Disease Relevance 1.04 Pain Relevance 0.04
ApoA-I increases apoE secretion with minimal effect upon apoE gene expression
Positive_regulation (upon) of Gene_expression (expression) of apoE gene
3) Confidence 0.48 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.38 Pain Relevance 0
Several polymorphisms in the promotor gene are thought to increase susceptibility to AD by increasing expression of APOE ?
Positive_regulation (increasing) of Gene_expression (expression) of APOE
4) Confidence 0.40 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626927 Disease Relevance 0.79 Pain Relevance 0.10
However, APOE ?
Positive_regulation (However) of Gene_expression (However) of APOE
5) Confidence 0.35 Published 2010 Journal Alzheimers Res Ther Section Body Doc Link PMC2919699 Disease Relevance 2.63 Pain Relevance 0

General Comments

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