INT96775

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Context Info
Confidence 0.54
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 29.78
Pain Relevance 15.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pdgfa) extracellular region (Pdgfa)
Anatomy Link Frequency
Platelet 8
neurons 5
lung 3
fibroblasts 2
mesenchymal cells 2
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 242 100.00 Very High Very High Very High
Brush evoked pain 286 99.96 Very High Very High Very High
Spinal cord 168 99.96 Very High Very High Very High
Stimulus evoked pain 28 99.96 Very High Very High Very High
Dorsal horn neuron 112 99.84 Very High Very High Very High
intrathecal 204 99.74 Very High Very High Very High
Neuropathic pain 216 99.42 Very High Very High Very High
metalloproteinase 27 98.68 Very High Very High Very High
cerebral cortex 16 98.44 Very High Very High Very High
fibrosis 1267 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cirrhosis 27 100.00 Very High Very High Very High
Neuropathic Pain 532 99.96 Very High Very High Very High
Pain 131 99.96 Very High Very High Very High
Nervous System Injury 242 99.80 Very High Very High Very High
Hypersensitivity 69 99.76 Very High Very High Very High
Pancreatic Cancer 71 99.68 Very High Very High Very High
Malignant Neoplastic Disease 6 99.64 Very High Very High Very High
Experimental Melanoma 21 99.48 Very High Very High Very High
Wound Healing 38 99.40 Very High Very High Very High
Targeted Disruption 351 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among more than 50 known angiogenic factors (including matrix metalloproteinases, adhesion molecules, enzymes, and growth factors), we found that expression levels of PDGF-B, PDGF receptor ?
Gene_expression (expression) of PDGF associated with metalloproteinase and adhesions
1) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 1.23 Pain Relevance 0.24
Increased plasma levels of PDGF after laparotomy may be responsible for accelerated tumor growth following laparotomy in mice.


Gene_expression (levels) of PDGF in plasma
2) Confidence 0.52 Published 2001 Journal Surg Endosc Section Body Doc Link 11443442 Disease Relevance 0 Pain Relevance 0
Recently, it has been reported that both thrombin-sensitive protease-activated receptor 1 (PAR-1) and platelet-derived growth factor (PDGF) are present not only in platelets, but also in the CNS, which indicates that they have various physiological functions.
Gene_expression (present) of platelet-derived growth factor in platelets
3) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16251448 Disease Relevance 0.50 Pain Relevance 0.61
Recently, it has been reported that both thrombin-sensitive protease-activated receptor 1 (PAR-1) and platelet-derived growth factor (PDGF) are present not only in platelets, but also in the CNS, which indicates that they have various physiological functions.
Gene_expression (present) of PDGF in platelets
4) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16251448 Disease Relevance 0.50 Pain Relevance 0.61
Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-?
Gene_expression (receptor) of Platelet-derived growth factor in Platelet
5) Confidence 0.31 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.57 Pain Relevance 0
Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-?
Gene_expression (receptor) of PDGF in Platelet
6) Confidence 0.31 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.57 Pain Relevance 0
These include platelet-derived growth factor (PDGF) [33], interleukin-1 (IL-1) [34], tumor necrosis factor ?
Gene_expression (include) of platelet-derived growth factor in platelet associated with necrosis and cancer
7) Confidence 0.29 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 1.26 Pain Relevance 0.43
-SMA-stained thigh muscle of the mice showed a significant increase in mean vessel diameters and a distribution towards larger, mature vessels in VEGF/PDGF group (Fig. 8).
Gene_expression (group) of PDGF in vessels
8) Confidence 0.28 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0 Pain Relevance 0
Accelerated Recovery of Hindlimb Blood Flow by VEGF/PDGF
Gene_expression (/) of PDGF in Blood
9) Confidence 0.28 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.10 Pain Relevance 0.05
Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-?
Gene_expression (receptor) of PDGF in Platelet
10) Confidence 0.27 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.57 Pain Relevance 0
Second, the expression of PDGF and its receptors are increased in lung tissue during the mesenchymal cell proliferative phase of pulmonary fibrosis in rodent models where injury is induced by agents such as bleomycin [29,30], asbestos [31,32], metals [33] or nanoparticles [34,35].
Gene_expression (expression) of PDGF in lung associated with fibrosis, injury and pulmonary fibrosis
11) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.55 Pain Relevance 0.14
Fourth, PDGF is produced by lung macrophages, epithelial cells and mesenchymal cells in vitro following stimulation with particles or fibers [37,38].
Gene_expression (produced) of PDGF in macrophages
12) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.68 Pain Relevance 0.12
For example, the effect of IL-13-induced PDGF-AA production by rat lung myofibroblasts is further amplified by IL-1?
Gene_expression (production) of PDGF in lung
13) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.92 Pain Relevance 0.37
is antimitogenic toward lung fibroblasts, it also enhances particle-induced PDGF production by alveolar macrophages [78] and enhances the proliferative activity of PDGF and EGF for lung fibroblasts isolated from mice deficient in the STAT-1 transcription factor [79].
Gene_expression (production) of PDGF in fibroblasts
14) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.65 Pain Relevance 0.28
STAT-6 also mediates IL-13-induced production of PDGF-AA in rodent and human lung fibroblasts [73].
Gene_expression (production) of PDGF in fibroblasts
15) Confidence 0.21 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 1.31 Pain Relevance 0.12
A similar phenotype is seen in genetically partially rescued PDGF-R?
Gene_expression (rescued) of PDGF
16) Confidence 0.21 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.94 Pain Relevance 0.06
The targeted overexpression of PDGF ligands in the lungs of transgenic mice produces a lethal phenotype associated with hyperplasia of mesenchymal cells [43-46].
Gene_expression (overexpression) of PDGF in mesenchymal cells associated with targeted disruption and hyperplasia
17) Confidence 0.21 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.96 Pain Relevance 0.06
Moreover, overexpression of PDGF can also contribute to increased IFP of tumors, since PDGF inhibition decreases tumor IFP [6].
Gene_expression (overexpression) of PDGF associated with cancer
18) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781164 Disease Relevance 0.76 Pain Relevance 0.10
These events act in opposition to and occur after the profibrogenic actions of V2O5 in mice and rats that results from increased expression and activation of profibrogenic growth factors such as PDGF, TGF-?
Gene_expression (expression) of PDGF
19) Confidence 0.19 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.41 Pain Relevance 0.16
However, overexpression of PDGF or its receptors is thought to play a pivotal role in the progression of fibrotic diseases [25].
Gene_expression (overexpression) of PDGF associated with fibrosis and disease
20) Confidence 0.19 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.35 Pain Relevance 0.10

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