INT96776

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 7.79
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pdgfa) extracellular region (Pdgfa)
Anatomy Link Frequency
fibroblasts 4
Blood 2
plasma 2
lung 2
mesenchymal cells 2
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 22 98.44 Very High Very High Very High
Inflammation 85 97.88 Very High Very High Very High
fibrosis 606 96.92 Very High Very High Very High
spinal dorsal horn 6 94.16 High High
intrathecal 42 93.60 High High
Brush evoked pain 60 92.72 High High
Pain 23 89.44 High High
Stimulus evoked pain 6 88.68 High High
Neuropathic pain 45 86.12 High High
Dorsal horn neuron 24 84.84 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 57 99.68 Very High Very High Very High
Malignant Neoplastic Disease 4 99.64 Very High Very High Very High
Targeted Disruption 42 99.00 Very High Very High Very High
Injury 100 98.88 Very High Very High Very High
Cancer 129 98.36 Very High Very High Very High
Colon Cancer 3 97.96 Very High Very High Very High
INFLAMMATION 121 97.88 Very High Very High Very High
Pulmonary Fibrosis 408 97.32 Very High Very High Very High
Fibrosis 348 97.04 Very High Very High Very High
Disease 60 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma levels of PDGF after laparotomy may be responsible for accelerated tumor growth following laparotomy in mice.


Positive_regulation (Increased) of Gene_expression (levels) of PDGF in plasma
1) Confidence 0.40 Published 2001 Journal Surg Endosc Section Body Doc Link 11443442 Disease Relevance 0 Pain Relevance 0
is antimitogenic toward lung fibroblasts, it also enhances particle-induced PDGF production by alveolar macrophages [78] and enhances the proliferative activity of PDGF and EGF for lung fibroblasts isolated from mice deficient in the STAT-1 transcription factor [79].
Positive_regulation (enhances) of Gene_expression (production) of PDGF in fibroblasts
2) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.71 Pain Relevance 0.31
Second, the expression of PDGF and its receptors are increased in lung tissue during the mesenchymal cell proliferative phase of pulmonary fibrosis in rodent models where injury is induced by agents such as bleomycin [29,30], asbestos [31,32], metals [33] or nanoparticles [34,35].
Positive_regulation (increased) of Gene_expression (expression) of PDGF in lung associated with fibrosis, injury and pulmonary fibrosis
3) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.56 Pain Relevance 0.14
Accelerated Recovery of Hindlimb Blood Flow by VEGF/PDGF
Positive_regulation (by) of Gene_expression (/) of PDGF in Blood
4) Confidence 0.21 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.10 Pain Relevance 0.05
Moreover, overexpression of PDGF can also contribute to increased IFP of tumors, since PDGF inhibition decreases tumor IFP [6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF associated with cancer
5) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781164 Disease Relevance 0.76 Pain Relevance 0.10
The targeted overexpression of PDGF ligands in the lungs of transgenic mice produces a lethal phenotype associated with hyperplasia of mesenchymal cells [43-46].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF in mesenchymal cells associated with targeted disruption and hyperplasia
6) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.96 Pain Relevance 0.06
However, overexpression of PDGF or its receptors is thought to play a pivotal role in the progression of fibrotic diseases [25].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF associated with fibrosis and disease
7) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.35 Pain Relevance 0.10
is antimitogenic toward lung fibroblasts, it also enhances particle-induced PDGF production by alveolar macrophages [78] and enhances the proliferative activity of PDGF and EGF for lung fibroblasts isolated from mice deficient in the STAT-1 transcription factor [79].
Positive_regulation (induced) of Gene_expression (production) of PDGF in fibroblasts
8) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.65 Pain Relevance 0.28
These events act in opposition to and occur after the profibrogenic actions of V2O5 in mice and rats that results from increased expression and activation of profibrogenic growth factors such as PDGF, TGF-?
Positive_regulation (increased) of Gene_expression (expression) of PDGF
9) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.41 Pain Relevance 0.16
Following PDGF administration, the immunofluorescence for phosphorylated PDGF ?
Positive_regulation (Following) of Gene_expression (immunofluorescence) of PDGF
10) Confidence 0.07 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2690582 Disease Relevance 0.97 Pain Relevance 1.04
1 in pancreatic cancer cells and both PDGF receptors are overexpressed in this malignancy.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PDGF associated with malignant neoplastic disease and pancreatic cancer
11) Confidence 0.06 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.19 Pain Relevance 0.18
l, as a vehicle control) was intrathecally administered 30 min before PDGF-BB (10 pmol/10 ?
Positive_regulation (administered) of Gene_expression (administered) of PDGF
12) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.22 Pain Relevance 0.47
Following PDGF administration, the immunofluorescence for phosphorylated PDGF ?
Positive_regulation (Following) of Gene_expression (administration) of PDGF
13) Confidence 0.06 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2690582 Disease Relevance 0.92 Pain Relevance 1.04

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