INT96777

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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.86
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pdgfa) extracellular region (Pdgfa)
Anatomy Link Frequency
platelet 5
macrophages 1
blood vessels 1
muscle 1
epithelial cells 1
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 22 100.00 Very High Very High Very High
Neurotransmitter 4 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
Dorsal horn neuron 16 99.76 Very High Very High Very High
Peripheral nerve injury 10 99.48 Very High Very High Very High
Inflammation 118 98.62 Very High Very High Very High
Brush evoked pain 40 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 18 100.00 Very High Very High Very High
Nervous System Injury 34 99.48 Very High Very High Very High
INFLAMMATION 164 98.62 Very High Very High Very High
Cancer 28 98.48 Very High Very High Very High
Cholestasis 66 98.38 Very High Very High Very High
Neuropathic Pain 74 98.28 Very High Very High Very High
Hyperalgesia 2 97.40 Very High Very High Very High
Radiation Sickness 1 96.72 Very High Very High Very High
Pain 19 92.96 High High
Wound Healing 6 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased platelet-derived growth factor (PDGF) release after laparotomy stimulates systemic tumor growth in mice.
Localization (release) of platelet-derived growth factor in platelet associated with cancer
1) Confidence 0.79 Published 2001 Journal Surg Endosc Section Title Doc Link 11443442 Disease Relevance 0.45 Pain Relevance 0.17
Increased platelet-derived growth factor (PDGF) release after laparotomy stimulates systemic tumor growth in mice.
Localization (release) of PDGF in platelet associated with cancer
2) Confidence 0.79 Published 2001 Journal Surg Endosc Section Title Doc Link 11443442 Disease Relevance 0.45 Pain Relevance 0.17
The theory is also confirmed by the current study, showing that the initial delivery of VEGF, following by a sustained release of PDGF, led to not only the formation but also the maturation of blood vessels.
Localization (release) of PDGF in blood vessels
3) Confidence 0.34 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0 Pain Relevance 0
A better, synchronized control of angiogenic cascade may be required for the formation of functional, stable vascular beds, since VEGF delivery followed by PDGF resulted in larger, mature vessel structures (4,5).
Localization (followed) of PDGF
4) Confidence 0.31 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0 Pain Relevance 0
Fig. 1In vitro release kinetics of pre-encapsulated PDGF and VEGF from alginate fabricated from PLG.Fig. 2Representative image of CD 31 staining of thigh muscle treated by intramuscular injection of alginate containing VEGF at week 3, ×200.
Localization (release) of PDGF in muscle
5) Confidence 0.30 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.08 Pain Relevance 0.04
As illustrated in Figure 3, PDGF ligands secreted by epithelial cells and macrophages contribute to the replicative and migratory myofibroblast phenotype.
Localization (secreted) of PDGF in epithelial cells
6) Confidence 0.26 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.70 Pain Relevance 0.11
Thus, PDGF released from dorsal horn neurons is implicated in neuropathic pain.
Localization (released) of PDGF in dorsal horn associated with neuropathic pain and dorsal horn neuron
7) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.73 Pain Relevance 0.79
The zinc-finger protein Egr-1 is located in the nucleus [32-34] and has numerous target genes [35], among which are PDGF-A [36] and PDGF-B [37], bFGF [38] and TGF-?
Localization (located) of PDGF in nucleus
8) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.19 Pain Relevance 0.03
As illustrated in Figure 3, PDGF ligands secreted by epithelial cells and macrophages contribute to the replicative and migratory myofibroblast phenotype.
Localization (secreted) of PDGF in macrophages
9) Confidence 0.09 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.70 Pain Relevance 0.11
l, as a vehicle control) was intrathecally administered on day 7 after PDGF-BB (10 pmol/10 ?
Localization (administered) of PDGF
10) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.30 Pain Relevance 0.60
However, during their intense proliferation in obstructive cholestasis, proliferating cholangiocytes acquire the phenotype of neuroendocrine cells and secrete different substances including neurotransmitters (serotonin) [137], neuropeptides (opioid peptides such as met-enkephalin) [138-141], hormones (prolactin) [142] and their receptors (estrogens) [11] and growth factors, (that is, insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), TGF?
Localization (secrete) of platelet-derived growth factor in platelet associated with cholestasis, neurotransmitter, neuropeptide, enkephalin, opioid and serotonin
11) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.93 Pain Relevance 0.62
However, during their intense proliferation in obstructive cholestasis, proliferating cholangiocytes acquire the phenotype of neuroendocrine cells and secrete different substances including neurotransmitters (serotonin) [137], neuropeptides (opioid peptides such as met-enkephalin) [138-141], hormones (prolactin) [142] and their receptors (estrogens) [11] and growth factors, (that is, insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), TGF?
Localization (secrete) of PDGF in platelet associated with cholestasis, neurotransmitter, neuropeptide, enkephalin, opioid and serotonin
12) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.93 Pain Relevance 0.62
This vascular pro-inflammatory role for the platelets is played by their secretory granules, which secrete chemokines for leukocyte adhesion (Weber 2005), platelet-derived growth factor (PDGF) as a potent growth factor for vascular smooth muscle cells (Lamb et al 2001) and TGF-?
Localization (secrete) of PDGF in platelet associated with chemokine, inflammation and adhesions
13) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.38 Pain Relevance 0.26

General Comments

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