INT96778

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 12.70
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pdgfa) extracellular region (Pdgfa)
Anatomy Link Frequency
platelet 5
Spinal cord 2
plasma 1
muscle 1
fibroblasts 1
Pdgfa (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 37 100.00 Very High Very High Very High
metalloproteinase 18 100.00 Very High Very High Very High
Kinase C 1 100.00 Very High Very High Very High
Dorsal horn 38 99.52 Very High Very High Very High
aspirin 8 99.46 Very High Very High Very High
fibrosis 847 99.44 Very High Very High Very High
tolerance 15 99.00 Very High Very High Very High
Spinal cord 67 98.88 Very High Very High Very High
Inflammatory response 56 98.40 Very High Very High Very High
Dopamine 1 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 43 99.52 Very High Very High Very High
Pulmonary Fibrosis 497 99.44 Very High Very High Very High
Cancer 38 99.40 Very High Very High Very High
Fibrosis 546 99.38 Very High Very High Very High
Injury 153 98.88 Very High Very High Very High
Nervous System Injury 34 98.80 Very High Very High Very High
Cirrhosis 41 98.60 Very High Very High Very High
INFLAMMATION 273 98.22 Very High Very High Very High
Wound Healing 23 98.08 Very High Very High Very High
Disease 87 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased platelet-derived growth factor (PDGF) release after laparotomy stimulates systemic tumor growth in mice.
Positive_regulation (Increased) of platelet-derived growth factor in platelet associated with cancer
1) Confidence 0.46 Published 2001 Journal Surg Endosc Section Title Doc Link 11443442 Disease Relevance 0.45 Pain Relevance 0.17
i-coupled receptor) results in transactivation of platelet derived growth factor ?
Positive_regulation (transactivation) of platelet derived growth factor in platelet
2) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.27 Pain Relevance 0.65
Elucidating the secondary signaling molecules that are necessary for platelet-derived growth factor (PDGF) to stimulate tumor development will be crucial to the understanding and treatment of a variety of cancers.
Positive_regulation (necessary) of PDGF in platelet associated with cancer
3) Confidence 0.42 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.20 Pain Relevance 0
Increased plasma levels of PDGF after laparotomy may be responsible for accelerated tumor growth following laparotomy in mice.


Positive_regulation (Increased) of PDGF in plasma
4) Confidence 0.40 Published 2001 Journal Surg Endosc Section Body Doc Link 11443442 Disease Relevance 0 Pain Relevance 0
Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells.
Positive_regulation (required) of PDGF associated with aspirin
5) Confidence 0.30 Published 2002 Journal Exp. Cell Res. Section Title Doc Link 11855867 Disease Relevance 0.25 Pain Relevance 0.18
Third, PDGFs are potent mitogens and chemoattractants for mesenchymal cells in lung and other organ systems [25], and PDGF receptor activation is essential for mesenchymal cell migration in wound healing [36].
Positive_regulation (activation) of PDGF in organ systems associated with wound healing
6) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.62 Pain Relevance 0.12
These events act in opposition to and occur after the profibrogenic actions of V2O5 in mice and rats that results from increased expression and activation of profibrogenic growth factors such as PDGF, TGF-?
Positive_regulation (activation) of PDGF
7) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.41 Pain Relevance 0.16
Fig. 1In vitro release kinetics of pre-encapsulated PDGF and VEGF from alginate fabricated from PLG.Fig. 2Representative image of CD 31 staining of thigh muscle treated by intramuscular injection of alginate containing VEGF at week 3, ×200.
Positive_regulation (encapsulated) of PDGF in muscle
8) Confidence 0.21 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.08 Pain Relevance 0.04
, which upregulates the PDGF-R?
Positive_regulation (upregulates) of PDGF
9) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.93 Pain Relevance 0.41
As illustrated in Figure 3, IL-13 generated during a Th2 inflammatory response is important in airway and interstitial fibrosis due in part to its ability to increase PDGF and TGF-?
Positive_regulation (increase) of PDGF associated with fibrosis and inflammatory response
10) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 1.71 Pain Relevance 0.70
First, PDGF ligands are elevated in patients with idiopathic pulmonary fibrosis, and immunohistochemical studies have shown that increased expression of PDGFs occurs at sites of fibroproliferative lesions [28].
Positive_regulation (elevated) of PDGF associated with fibrosis and pulmonary fibrosis
11) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.53 Pain Relevance 0.14
Moreover, STAT-3 activation in response to PDGF or EGF, a prosurvival signaling event for mesenchymal cells, is significantly greater in STAT-1-/- mouse lung fibroblasts compared to STAT-1+/+ fibroblasts.
Positive_regulation (activation) of PDGF in fibroblasts
12) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.63 Pain Relevance 0.12
However, overexpression of PDGF or its receptors is thought to play a pivotal role in the progression of fibrotic diseases [25].
Positive_regulation (overexpression) of PDGF associated with fibrosis and disease
13) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.35 Pain Relevance 0.10
Profibrogenic growth factors, including platelet-derived growth factor (PDGF) and its receptor, are elevated in rats exposed to V2O5 [15].
Positive_regulation (elevated) of platelet-derived growth factor in platelet
14) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.76 Pain Relevance 0.32
It is thus possible that the enhanced PDGFR activity might be due to an increase in the level of endogenous PDGF within the dorsal horn after nerve injury, as suggested by a previous study [24].
Positive_regulation (increase) of PDGF in nerve associated with nervous system injury and dorsal horn
15) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.81 Pain Relevance 0.59
The results suggest that PI 3-kinase activity is required for PDGF-stimulated PSC migration but not proliferation [49,55].
Positive_regulation (required) of PDGF associated with primary sclerosing cholangitis
16) Confidence 0.06 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.44 Pain Relevance 0.10
in the dorsal horns of vehicle-treated rats remained at low levels, but was markedly increased 30 min after intrathecal PDGF-BB (10 pmol) administration (P < 0.001) (Figure 2A, B).
Positive_regulation (increased) of PDGF in dorsal horns associated with intrathecal
17) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.20 Pain Relevance 0.43
This is emphasized by observations of lack of differentiation of O-2A cells into oligodendrocytes [86] and differentiation of endothelial progenitors into smooth muscle cells, potentially increasing the thickness of the blood vessel wall [87] after treatment with PDGF-BB.
Positive_regulation (increasing) of PDGF in smooth muscle cells
18) Confidence 0.05 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.15 Pain Relevance 0.07
Spinal cord experiments suggest that other growth factors, such as platelet-derived growth factor (PDGF) can increase the long-term radiation tolerance by approximately 5% (two fractions of 16–20 Gy 24 h apart, PDGF given intrathecally for 4 days starting 24 h before the first fraction of radiation) [44].
Positive_regulation (increase) of PDGF in Spinal cord associated with tolerance and spinal cord
19) Confidence 0.05 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.46 Pain Relevance 0.29
Spinal cord experiments suggest that other growth factors, such as platelet-derived growth factor (PDGF) can increase the long-term radiation tolerance by approximately 5% (two fractions of 16–20 Gy 24 h apart, PDGF given intrathecally for 4 days starting 24 h before the first fraction of radiation) [44].
Positive_regulation (increase) of platelet-derived growth factor in Spinal cord associated with tolerance and spinal cord
20) Confidence 0.05 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.46 Pain Relevance 0.29

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