INT9678
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
RESULTS: Clonidine induced a slight but significant increase in plasma GH values, peaking 60 to 120 minutes later; however, no significant changes were observed in indices of total and pulsatile GH release for the whole sampling period in this study. | |||||||||||||||
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These results indicate that the increase in plasma GH induced by alpha 2-adrenergic stimulation in normotensive subjects involves opioid receptors with moderate sensitivity to naloxone. | |||||||||||||||
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In the present investigations, the effect of naloxone on the increase in plasma GH induced by clonidine and the more specific alpha 2-agonist guanfacine was studied in man. | |||||||||||||||
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Clonidine induced a significant increase in plasma GH. | |||||||||||||||
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In the present study the effect of the opiate receptor blocker naloxone on the increase in plasma GH induced by clonidine was investigated in eight patients with essential hypertension. | |||||||||||||||
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These tests both produced a wide variation in GH response in normal volunteers, considerable GH release following hp GRF 1-44 amide but little after clonidine in idiopathic GH deficiency, and indistinguishable, negligible responses in patients with craniopharyngiomas and pituitary tumours associated with GH deficiency. | |||||||||||||||
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While these data do not exclude the possibility of a short loop feedback control of GH secretion, they strongly suggest that the direction of the GH response to a provocative stimulus is determined by the antecedent GH level and that an alpha-adrenoreceptor mechanism is involved in such a biphasic modulation of GH levels. | |||||||||||||||
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When administered alone, CLON and PD induced a similar GH increase (peak, mean +/- SE: 14.6 +/- 2.4 vs 14.2 +/- 3.1 ng/ml; area under curve, AUC: 376.9 +/- 57.6 vs 390.0 +/- 74.3 ng/ml/h). | |||||||||||||||
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Hexarelin induced a slight increase in GH levels which was similar to that after GHRH but far lower (P < 0.01) than that after rhGH. | |||||||||||||||
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The cardiotropic effect of hexarelin is not shared by GHRH or by rhGH, indicating that it is not mediated by the increase in circulating GH levels but more likely reflects activation of specific cardiovascular GH secretagogue receptors. | |||||||||||||||
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Both clonidine and guanfacine induced an increase in plasma GH (P less than 0.05). | |||||||||||||||
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These results indicate that the increase in plasma GH induced by alpha 2-adrenergic stimulation in normotensive subjects involves opioid receptors with moderate sensitivity to naloxone. | |||||||||||||||
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In the present investigations, the effect of naloxone on the increase in plasma GH induced by clonidine and the more specific alpha 2-agonist guanfacine was studied in man. | |||||||||||||||
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In the control studies, exercise induced a significant increase in GH, PRL, TSH and ACTH. | |||||||||||||||
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These results demonstrate that TRH not only overcomes GH refractoriness to hpGRF and vice versa, but the GH response to heterologous provocative stimuli is potentiated in birds refractory to TRH or hp GRF challenge. | |||||||||||||||
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In conclusion, these results suggest that correction of the anemia with rhEPO therapy potentiates GH responses to direct pituitary stimulation with GHRH although it is unable to restore the blunted response of GH to clonidine that is found in CAPD patients. | |||||||||||||||
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However, the increase was less pronounced in response to clonidine and moxonidine as compared to GHRH (mean +/- SEM): after clonidine, GH increased from 0.2 +/- 0.1 to 5.4 +/- 1.5 ng/ml, p < 0.05; moxonidine increased GH levels from 0.1 +/- 0.04 to 4.8 +/- 1.9 ng/ml (p < 0.05); GHRH caused an increase from 0.01 +/- 0.05 to 14.8 +/- 2.5 ng/ml (p < 0.05). | |||||||||||||||
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However, as the individual subjects profiles were back to baseline by 2022 h, it is concluded that no overall accumulation of GH occurs. | |||||||||||||||
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Conversely, either beta-adrenergic blockade (PRO), or alpha 2-adrenergic agonism (CLO), or the enhancement of muscarinic cholinergic tone (PD) significantly increased the GH response to GHRH (peaks: 43 +/- 4.6, 55.6 +/- 5.6 and 51.2 +/- 7, micrograms/L; PRO, CLO, and PD, respectively; P < 0.01 vs. | |||||||||||||||
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An evaluation of data from children with ISS treated with GH, taken from a large GH database, showed that GH treatment resulted in an increase in height from ? | |||||||||||||||
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General Comments
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