INT96784

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA, Calca) aging (CALCA, Calca) extracellular region (CALCA, Calca)
nucleus (CALCA, Calca) intracellular (CALCA, Calca) cytoplasm (CALCA, Calca)
CALCA (Homo sapiens)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 40 100.00 Very High Very High Very High
antagonist 6 99.56 Very High Very High Very High
Migraine 5 97.88 Very High Very High Very High
agonist 2 70.16 Quite High
Potency 1 41.44 Quite Low
Disease Link Frequency Relevance Heat
Headache 5 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results collectively suggest that turn structures at both the C-terminus and N-terminus of CGRP(27-37)-NH(2) analogues may help to appropriately orient critical residues (T(30), V(32), and F(37)) for hCGRP(1) receptor binding.
CGRP Binding (binding) of CGRP associated with calcitonin gene-related peptide
1) Confidence 0.23 Published 2001 Journal Biochemistry Section Abstract Doc Link 11444978 Disease Relevance 0 Pain Relevance 0.19
In the study presented here, conformational and structural features in CGRP(27-37)-NH(2) analogues that are important for hCGRP(1) receptor binding were explored.
CGRP Binding (binding) of CGRP associated with calcitonin gene-related peptide
2) Confidence 0.22 Published 2001 Journal Biochemistry Section Abstract Doc Link 11444978 Disease Relevance 0.17 Pain Relevance 0.77
Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors--the role of receptor activity modifying protein 1.
gene-related peptide Binding (affinity) of CGRP associated with calcitonin gene-related peptide
3) Confidence 0.00 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16959943 Disease Relevance 0.10 Pain Relevance 0.51

General Comments

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