INT96797

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.21
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
neurons 2
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 1 99.90 Very High Very High Very High
opiate 4 99.80 Very High Very High Very High
antagonist 5 99.60 Very High Very High Very High
cocaine 41 97.84 Very High Very High Very High
mu opioid receptor 3 94.84 High High
Morphine 12 93.68 High High
cytokine 5 89.44 High High
Analgesic 10 77.12 Quite High
Opioid receptor 1 1 75.00 Quite High
Pain 17 71.00 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 198 100.00 Very High Very High Very High
Dementia 18 99.98 Very High Very High Very High
Toxicity 4 99.08 Very High Very High Very High
Death 4 96.32 Very High Very High Very High
Infection 10 89.44 High High
Hypersensitivity 23 82.48 Quite High
Apoptosis 11 82.24 Quite High
Anxiety Disorder 4 80.00 Quite High
Stress 2 74.80 Quite High
Pain 12 71.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of these tissues with the respective antagonists e.g., naloxone and anti-gp120 blocks the opiate decrease and increase gp120 induced increase in mu expression, respectively.
Negative_regulation (blocks) of anti-gp120 associated with antagonist, narcan and opiate
1) Confidence 0.42 Published 2001 Journal Int. J. Mol. Med. Section Abstract Doc Link 11445868 Disease Relevance 0.16 Pain Relevance 0.79
The ceramide precursor palmitoyl-CoA sensitized neurons to Tat and gp120 toxicity, whereas an inhibitor of ceramide production reduced Tat and gp120-induced increases of ceramide and HNE and protected the neurons from Tat and gp120-induced death.
Negative_regulation (reduced) of gp120 in neurons associated with toxicity and death
2) Confidence 0.18 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 14755730 Disease Relevance 1.46 Pain Relevance 0.13
However, at day 14 post surgery exploration of the centre of the arena (as calculated by the number of entries into the inner zone and the time spent in the inner zone) was significantly decreased in HIV-1 gp120 treated animals as compared to shams or to either treatment group at day 7(Fig. 2B–D).
Negative_regulation (decreased) of gp120 associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.18 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.88 Pain Relevance 0.61
This agent acts through allosteric inhibition of the CCR5 receptor, preventing its interaction with gp120 and thus avoiding subsequent cellular entry by HIV.
Negative_regulation (preventing) of gp120 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.16 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.44 Pain Relevance 0.10
Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef.



Negative_regulation (displayed) of gp120 in neurons associated with dementia, acquired immune deficiency syndrome or hiv infection and cocaine
5) Confidence 0.12 Published 2008 Journal The Open Virology Journal Section Abstract Doc Link PMC2678818 Disease Relevance 0.27 Pain Relevance 0.17

General Comments

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