INT96815

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
astrocytes 2
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 2 93.24 High High
tetrodotoxin 1 90.52 High High
Action potential 1 89.80 High High
Bioavailability 1 84.32 Quite High
Catecholamine 3 69.36 Quite High
Dopamine 4 58.72 Quite High
Central nervous system 6 19.84 Low Low
imagery 26 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
magnetoencephalography 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 97 88.32 High High
Alzheimer's Dementia 3 88.16 High High
Disease 13 79.40 Quite High
Disorder Of Lipid Metabolism 3 75.00 Quite High
Convulsion 2 65.60 Quite High
Amyloid Plaque 1 60.00 Quite High
Cognitive Disorder 57 39.60 Quite Low
Dementia 1 31.80 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 31.12 Quite Low
Vascular Disease 1 30.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of ApoE in astrocytes is controlled by several receptor/effector systems such as adrenoceptors and cAMP.
Regulation (controlled) of Gene_expression (production) of ApoE in astrocytes
1) Confidence 0.62 Published 2001 Journal Biochem. Soc. Symp. Section Abstract Doc Link 11447828 Disease Relevance 0.36 Pain Relevance 0.22
Expression of the APOE gene is influenced by the APOE promoter gene, which also exists as one of several polymorphisms that can either up or down regulate apoE production.
Regulation (regulate) of Gene_expression (production) of apoE
2) Confidence 0.21 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626927 Disease Relevance 0.74 Pain Relevance 0.06

General Comments

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