INT96816

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.62
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
plasma 1
adipocytes 1
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 5 100.00 Very High Very High Very High
Action potential 1 99.20 Very High Very High Very High
tetrodotoxin 1 98.28 Very High Very High Very High
Inflammation 21 91.92 High High
Calcium channel 1 91.36 High High
Hippocampus 1 62.40 Quite High
Bioavailability 1 57.28 Quite High
cytokine 4 54.32 Quite High
cINOD 3 37.12 Quite Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 52 100.00 Very High Very High Very High
INFLAMMATION 28 100.00 Very High Very High Very High
Obesity 61 99.28 Very High Very High Very High
Disease 194 99.24 Very High Very High Very High
Parkinson's Disease 7 98.32 Very High Very High Very High
Cardiovascular Disease 43 98.04 Very High Very High Very High
Neurodegenerative Disease 37 94.80 High High
Sprains And Strains 1 94.52 High High
Pre-eclampsia 100 92.60 High High
Stress 16 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2 carriers [19,21] or no effect of APOE genotype on plasma CRP at all [22].
Neg (no) Regulation (effect) of APOE in plasma
1) Confidence 0.45 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.31 Pain Relevance 0
However, we have clearly demonstrated that the APOE genotype influences CRP concentrations.
Regulation (influences) of APOE
2) Confidence 0.45 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.86 Pain Relevance 0.08
In addition, MB, SF, RH and SB gave expert advice on the HLA region and on search strategies in the region; MB supervised the HLA genotyping and was responsible for quality control; IQ and AS performed the HLA genotyping; DRW isolated the DNA and performed the APOE genotyping; LB supplied all the background data on the OPTIMA cohort; DJL was responsible for the data analysis and drafted the manuscript; MB, SB and ADS also made important contributions to the final draft.



Regulation (performed) of APOE
3) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.86 Pain Relevance 0
Genotype–phenotype correlations presented here, corrected for codon 129, demonstrate an effect of APOE genotype on age at onset, with individuals carrying the E4 allele having a significantly later age at onset than those without.
Regulation (effect) of APOE
4) Confidence 0.38 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.26 Pain Relevance 0
Such include the influences of misfolded proteins (Apolipoprotein E, ?
Regulation (influences) of Apolipoprotein E associated with disorder of lipid metabolism
5) Confidence 0.35 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 1.85 Pain Relevance 0.09
The ApoE effects on calcium are not affected by the blockade of action potentials with tetrodotoxin, or by inhibition of common ApoE binding sites.
Neg (not) Regulation (affected) of ApoE associated with tetrodotoxin and action potential
6) Confidence 0.27 Published 2001 Journal Biochem. Soc. Symp. Section Abstract Doc Link 11447828 Disease Relevance 0.40 Pain Relevance 0.22
We demonstrate that apoA-I induces a strong increase in cholesterol release and apoE secretion from adipocytes, whereas it has no transcriptional effect on ABCA1 or apoE genes.
Neg (no) Regulation (effect) of apoE in adipocytes associated with obesity
7) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2917427 Disease Relevance 0.88 Pain Relevance 0
Apolipoprotein E (ApoE) is a major constituent of very low-density lipoproteins (VLDLs) whose role involves modifying inflammatory responses, and removal of excess cholesterol from the circulation via regulation of hepatic uptake (Belo et al 2004).
Regulation (regulation) of ApoE associated with inflammatory response and disorder of lipid metabolism
8) Confidence 0.23 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.20 Pain Relevance 0.05

General Comments

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