INT9682

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2011
Negated 8
Speculated 11
Reported most in Abstract
Documents 238
Total Number 249
Disease Relevance 120.03
Pain Relevance 26.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
plasma 7
pituitary 7
liver 6
blood 6
molar 5
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 219 100.00 Very High Very High Very High
Clonidine 72 100.00 Very High Very High Very High
Bioavailability 69 100.00 Very High Very High Very High
opioid receptor 3 99.82 Very High Very High Very High
Fibrositis 76 99.80 Very High Very High Very High
dexamethasone 49 99.80 Very High Very High Very High
spinal inflammation 4 99.80 Very High Very High Very High
agonist 146 99.68 Very High Very High Very High
qutenza 33 99.68 Very High Very High Very High
cytokine 347 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 234 100.00 Very High Very High Very High
Polio 2 100.00 Very High Very High Very High
Retinoblastoma 1 100.00 Very High Very High Very High
Diabetes Mellitus 540 99.98 Very High Very High Very High
Syndrome 197 99.96 Very High Very High Very High
Chronic Fatigue Syndrome 236 99.92 Very High Very High Very High
Growth Problems 218 99.84 Very High Very High Very High
Apoptosis 235 99.82 Very High Very High Very High
Insulin Resistance 294 99.80 Very High Very High Very High
Fibromyalgia 62 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cut-off of post-stimulated IGF-1 for the diagnosis of GHI is still debated, with different authors proposing different cut-off points.
Positive_regulation (stimulated) of IGF-1 associated with laron syndrome
1) Confidence 0.70 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.51 Pain Relevance 0.04
Further endocrinological tests demonstrated an increase of IGF-1 (somatomedin C), and another MRI scan of the sellar region confirmed the presence of a pituitary macroadenoma on the left paramedian side.
Positive_regulation (increase) of IGF-1 in pituitary
2) Confidence 0.69 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16355297 Disease Relevance 0.86 Pain Relevance 0.51
Pain was well correlated with the increased plasma levels of IGF-1.
Positive_regulation (increased) of IGF-1 in plasma associated with pain
3) Confidence 0.69 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16355297 Disease Relevance 0.81 Pain Relevance 0.51
These data suggest that increased IGF-1 levels correlate with elevated endogenous PGE2 levels in OA Ob and that higher IGF-1 levels in OA Ob could be important for bone sclerosis in OA.
Positive_regulation (increased) of IGF-1 in PGE2 associated with sclerosis and osteoarthritis
4) Confidence 0.69 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.27 Pain Relevance 0.59
However, based on this ethnomedical knowledge and our own observations that these extracts were anabolic in farmed fish (unpublished reports) whose growth is critically dependent on IGF-1, we hypothesized that the central mechanism of action for Lepidium meyenii extracts was the autocrine activation of IGF-1.
Positive_regulation (activation) of IGF-1
5) Confidence 0.69 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.44 Pain Relevance 0.26
A second claim was that Acclydine treatment works by increasing biologically active IGF1.
Positive_regulation (increasing) of IGF1
6) Confidence 0.69 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1876596 Disease Relevance 0.43 Pain Relevance 0
IGF1 studies in CFS patients have yielded conflicting results: low [8,9], normal [10,11], and increased [12] basal IGF1 levels have been found.
Positive_regulation (increased) of IGF1 associated with chronic fatigue syndrome
7) Confidence 0.69 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1876596 Disease Relevance 1.61 Pain Relevance 0.21
Pubertal induction with human chorionic gonadotropin in T adolescents was associated with increased IGF-I concentrations, GV, and HtSDS.
Positive_regulation (increased) of IGF-I
8) Confidence 0.68 Published 2009 Journal Hemoglobin Section Abstract Doc Link 20001614 Disease Relevance 0.07 Pain Relevance 0.07
CONCLUSION: To our knowledge, this is the first published report of obstructive hydrocephalus with a diverticulum of the third ventricle compressing the hypothalamus and increasing the serum levels of somatomedin-C.


Positive_regulation (increasing) of somatomedin-C in hypothalamus
9) Confidence 0.67 Published 1998 Journal Neurosurgery Section Body Doc Link 9588566 Disease Relevance 0.07 Pain Relevance 0
The initially increased serum somatomedin-C (Sm-C) levels normalized in 5 of these 10 patients; the mean values were 7.3 +/- 0.9 U/mL before and 2.9 +/- 0.7 U/mL at the end of therapy.
Positive_regulation (increased) of somatomedin-C
10) Confidence 0.67 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2888785 Disease Relevance 0.34 Pain Relevance 0.12
In 2 children with IGHD and all 4 with CGD, basal growth hormone (GH) and somatomedin-C levels were increased, pituitary GH response to challenges with a synthetic pancreatic GH releasing factor and clonidine was enhanced, and linear growth was stimulated.
Positive_regulation (increased) of somatomedin-C in pituitary associated with growth hormone deficiency and clonidine
11) Confidence 0.67 Published 1985 Journal Lancet Section Abstract Doc Link 2861413 Disease Relevance 0.28 Pain Relevance 0.27
The growth speed and the somatomedin C levels increased and the height SD score decreased, in 87% of the subjects.
Positive_regulation (increased) of somatomedin C
12) Confidence 0.67 Published 1989 Journal An. Esp. Pediatr. Section Abstract Doc Link 2631606 Disease Relevance 0.07 Pain Relevance 0.25
Further endocrinological tests demonstrated an increase of IGF-1 (somatomedin C), and another MRI scan of the sellar region confirmed the presence of a pituitary macroadenoma on the left paramedian side.
Positive_regulation (increase) of somatomedin C in pituitary
13) Confidence 0.67 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16355297 Disease Relevance 0.86 Pain Relevance 0.51
Increases in her IGF-1 levels at 12 months led to a further dose increase to 180 mg every three weeks.
Positive_regulation (Increases) of IGF-1
14) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.88 Pain Relevance 0.22
The peak total IGF-I values were increased to 4.0-4.8-fold at 16-24 h.
Positive_regulation (increased) of IGF-I
15) Confidence 0.67 Published 2005 Journal Growth Horm. IGF Res. Section Abstract Doc Link 16005252 Disease Relevance 0.43 Pain Relevance 0.05
Thus there is ample evidence to suggest that insulin resistant states increase free IGF-1 levels.
Positive_regulation (increase) of IGF-1
16) Confidence 0.65 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 0.88 Pain Relevance 0.05
Nevertheless, in response to human growth hormone (hGH) administration, both the yearly growth rate and IGF-I levels increased conspicuously.
Positive_regulation (increased) of IGF-I
17) Confidence 0.65 Published 1989 Journal Yonsei Med. J. Section Abstract Doc Link 2626840 Disease Relevance 0.39 Pain Relevance 0.06
This growth acceleration was accompanied by an increase in IGF-I concentration (from 52 +/- 21 ng/ml to 89 +/- 25 ng/ml).
Positive_regulation (increase) of IGF-I
18) Confidence 0.65 Published 1998 Journal Indian J Pediatr Section Abstract Doc Link 10773931 Disease Relevance 1.00 Pain Relevance 0.06
A possible explanation for this unexpected increase in IGF-1 could be that glucocorticoids inhibit the production of IGF-1 in the muscle, followed by a decrease in negative feedback regulation of liver IGF-1, which would increase serum levels of IGF-1 [46].
Positive_regulation (increase) of IGF-1 in liver
19) Confidence 0.63 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.23 Pain Relevance 0
At 12 months there was a significant increase in IGF-1 (+43; 18 to 76; p < 0.001) and IGFSD (0.90; 0.30 to 1.50; p < 0.001) in the P-group (corresponding figures for the NoP-group were +6; -17 to 29; p = 0.27; and 0.20; -0.40 to 0.70; p = 0.051, respectively) and the changes at 0 to 12 months in both variables were significantly greater in the P-group than in the NoP-group (p < 0.001 for both comparisons).


Positive_regulation (increase) of IGF-1
20) Confidence 0.63 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.17 Pain Relevance 0.08

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