INT9683
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man. | |||||||||||||||
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In healthy individuals, the kidney accounts for about 50% of the total MCR,23 and it is less than this in patients with renal disease,24 whereas extrarenal elimination (mostly via the liver) does not seem to differ significantly between the two groups.23 However, the situation is made more complex by the fact that GH also exists (reversibly) bound to GHBP, which is decreased in ESRD patients; the relative amounts of bound GH will most likely also correlate with the GH elimination rate. | |||||||||||||||
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The form in which GH is supplied and administered entails taking an inconvenient hospital method into the daily family routine. | |||||||||||||||
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Blood was sampled for GH radioimmunoassay at 0', 30', 60', 90', 120', 150', 180'. | |||||||||||||||
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These tests both produced a wide variation in GH response in normal volunteers, considerable GH release following hp GRF 1-44 amide but little after clonidine in idiopathic GH deficiency, and indistinguishable, negligible responses in patients with craniopharyngiomas and pituitary tumours associated with GH deficiency. | |||||||||||||||
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Growth hormone (GH)-binding protein regulation by estrogen, progesterone, and gonadotropins in human: the effect of ovulation induction with menopausal gonadotropins, GH, and gestation. | |||||||||||||||
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Familial isolated growth-hormone deficiency with advanced sexual maturation. | |||||||||||||||
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To our knowledge, this is the first report of a familial association between growth-hormone deficiency and advanced bone and sexual maturation. | |||||||||||||||
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Immunohistochemical analysis indicated positive reactivity for adrenocorticotropic hormone (ACTH) and growth hormone (GH), and in situ hybridization indicated the expression of proopiomelanocortin (POMC) and GH mRNA. | |||||||||||||||
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The reduced clearance observed for ESRD patients in the current study (58% of that for healthy individuals) is in agreement with other studies which have demonstrated a reduction in the metabolic clearance rate (MCR) of GH of about 50% for patients with chronic renal failure, and commensurate with a GH plasma half-life double that of healthy controls.2325 GH appears to be eliminated in humans by a biocompartmental model,25,33 with unbound GH in a central compartment and GHBPs and bound GH in a peripheral compartment. | |||||||||||||||
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The combination of GH/IGF-I was much more potent in improving nitrogen balance. | |||||||||||||||
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Tumor excision, usually by the trans-sphenoidal route, is the most rapid way of reducing GH and IGF-I concentrations in patients with acromegaly. | |||||||||||||||
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GH circulates in plasma as a mixture of different molecular forms: 22 kDa GH, 20 kDa GH, a GH-binding protein (GH-BP) linked form, dimers and polymers [61]. | |||||||||||||||
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Other difficult problems include a typical clinical picture of acromegaly in a patient with normal IGF-I and GH concentrations. | |||||||||||||||
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The reduced clearance observed for ESRD patients in the current study (58% of that for healthy individuals) is in agreement with other studies which have demonstrated a reduction in the metabolic clearance rate (MCR) of GH of about 50% for patients with chronic renal failure, and commensurate with a GH plasma half-life double that of healthy controls.2325 GH appears to be eliminated in humans by a biocompartmental model,25,33 with unbound GH in a central compartment and GHBPs and bound GH in a peripheral compartment. | |||||||||||||||
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Many who treat children with ISS believe that by increasing adult height they are improving quality of life.50 However, there is little objective data to support this notion.51 In fact, the idea that short stature is a problem that can be addressed by GH treatment has been recently challenged in the popular press.52 Recent reviews of available instruments for evaluating quality of life in children with GHD or ISS suggest that it should be possible to do the studies that could help answer whether treatment with GH has a positive or negative effect on quality of life.53,54 The question of efficacy of GH treatment is particularly relevant because of the expense of GH therapy: perhaps as much as US$52,634 per inch.55 In spite of the difficulty of demonstrating that an increase in height also results in increased quality of life, children with ISS have been treated with GH since at least the inception of the NCGS in 1985, accounting for approximately 20% of those patients treated with GH.56 Savage57 has suggested that 1) if growth hormone therapy is restricted to a height threshold of ? | |||||||||||||||
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GH circulates in plasma as a mixture of different molecular forms: 22 kDa GH, 20 kDa GH, a GH-binding protein (GH-BP) linked form, dimers and polymers [61]. | |||||||||||||||
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Sixteen healthy elderly women (mean age +/- SEM, 71.9 +/- 1.3 yr) were randomly assigned to receive either rhGH (GH; n = 5), low dose rhIGF-I (n = 6), or high dose rhIGF-I (n = 5). | |||||||||||||||
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A combination of two drugs was used: PIO (Actos 30 mg/d, Takeda Pharmaceuticals, http://www.tpna.com) or its placebo and recombinant human GH (Nutropin AQ 8 ? | |||||||||||||||
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The receptor protein, measured by [125I]GH binding, showed a time-delayed increase compared with the GHR mRNA changes. | |||||||||||||||
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General Comments
This test has worked.