INT96840

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.35
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hindlimb muscle 2
peripheral nerve 1
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 99.40 Very High Very High Very High
chemokine 1 94.32 High High
Action potential 2 90.16 High High
action potential duration 1 82.92 Quite High
cytokine 24 81.96 Quite High
Inflammation 3 81.56 Quite High
gABA 2 49.48 Quite Low
Sciatic nerve 11 19.52 Low Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 45 92.80 High High
Epstein-barr Virus 24 90.32 High High
Injury 8 85.60 High High
Hypergammaglobulinemia 1 83.36 Quite High
INFLAMMATION 4 81.56 Quite High
Parasitic Infection 1 64.60 Quite High
Viremia 1 62.00 Quite High
Sprains And Strains 15 60.24 Quite High
Hemolysis 1 56.44 Quite High
Targeted Disruption 10 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perfusion of hindlimb muscle with 0.1 mM tetrodotoxin (TTX, a Na+ channel blocker) decreased JinK by 15 +/- 1%, but had no effect on JoutK; subsequent addition of ouabain (5 mM) decreased JinK a further 32 +/- 2%.
Negative_regulation (decreased) of JinK in hindlimb muscle associated with tetrodotoxin
1) Confidence 0.33 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0.10
In vitro, 1.8 and 0.2 mM ouabain decreased JinK to a greater extent (83 +/- 5%) than in situ, but did not significantly affect 42K loss rate compared with controls.
Negative_regulation (decreased) of JinK
2) Confidence 0.33 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0
Perfusion of hindlimb muscle with 0.1 mM tetrodotoxin (TTX, a Na+ channel blocker) decreased JinK by 15 +/- 1%, but had no effect on JoutK; subsequent addition of ouabain (5 mM) decreased JinK a further 32 +/- 2%.
Negative_regulation (decreased) of JinK in hindlimb muscle associated with tetrodotoxin
3) Confidence 0.24 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0.10
Perfusion with 5 mM ouabain plus 2 mM tetracaine for 30 min decreased JinK 46 +/- 9% (0.30 +/- 0.03 to 0.16 +/- 0.02 micromol x min(-1) x g(-1)), however tetracaine was unable to abolish the ouabain-induced increase in unidirectional K+ efflux.
Negative_regulation (decreased) of JinK
4) Confidence 0.24 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11760095 Disease Relevance 0 Pain Relevance 0.08
This is relevant to the regenerative outcome because C57BL6/J mice, which express reduced amounts of classical MHC I compared to A/J animals, show decreased axonal growth in regenerating peripheral nerve and a delayed return of peripheral nerve function [26].
Negative_regulation (reduced) of MHC I in peripheral nerve
5) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.37 Pain Relevance 0.11
Both KSHV and MHV68 encode proteins, K3 and mK3, respectively, that downregulate MHC I [10].
Negative_regulation (downregulate) of MHC I
6) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.92 Pain Relevance 0.07
The present data suggest that B. cangicum venom contains at least two bioactive fractions whose activity on cell membranes seems to differ from the I K(Ca) blockade described previously.
Negative_regulation (blockade) of I K
7) Confidence 0.01 Published 2001 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 11449308 Disease Relevance 0.06 Pain Relevance 0.21

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