INT96842

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.15
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc11a1) plasma membrane (Slc11a1) lysosome (Slc11a1)
Anatomy Link Frequency
urothelial cells 2
bladder 2
T cell 2
J82 1
Slc11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 2 98.84 Very High Very High Very High
tetrodotoxin 1 98.08 Very High Very High Very High
Inflammatory response 31 97.68 Very High Very High Very High
cytokine 281 96.36 Very High Very High Very High
Inflammation 270 94.04 High High
action potential duration 1 90.44 High High
interstitial cystitis 24 49.92 Quite Low
Eae 6 47.68 Quite Low
cva 6 41.52 Quite Low
chemokine 55 25.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 246 99.68 Very High Very High Very High
Mycobacterial Infection 96 99.40 Very High Very High Very High
Infection 41 98.40 Very High Very High Very High
INFLAMMATION 327 97.68 Very High Very High Very High
Asthma 34 97.64 Very High Very High Very High
Disease 44 97.60 Very High Very High Very High
Hypersensitivity 35 96.12 Very High Very High Very High
Cicatrix 3 95.60 Very High Very High Very High
Increased Venous Pressure Under Development 4 95.32 Very High Very High Very High
Carcinoma 17 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NRAMP1 is also recruited to the phagosome where it catalyses cation transport and promotes phagosomal acidification [18].
NRAMP1 Binding (recruited) of
1) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.08 Pain Relevance 0
Also, tetrodotoxin could not block the action potentials in a Bcg-3-pretreated preparation, suggesting a possible interaction of Bcg-3 with Na+ channels.
Bcg-3 Binding (interaction) of associated with action potential and tetrodotoxin
2) Confidence 0.22 Published 2001 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 11449308 Disease Relevance 0.06 Pain Relevance 0.23
Treatment with BCG and rBCG-S1PT showed significantly increased level of TNF-?
rBCG Binding (Treatment) of
3) Confidence 0.16 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.71 Pain Relevance 0.07
Treatment with BCG and rBCG-S1PT showed significantly increased level of TNF-?
BCG Binding (Treatment) of
4) Confidence 0.14 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.71 Pain Relevance 0.07
Together, these results indicate that bladder instillation with BCG or TNF-?
BCG Binding (instillation) of in bladder
5) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.91 Pain Relevance 0.36
In phase 1, BCG adheres to the urothelium via interaction between the bacterial antigen 85 complex and fibronectin [6,12] and urothelial cells.
BCG Binding (interaction) of in urothelial cells
6) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.51 Pain Relevance 0.26
Here we went further to verify whether BCG-GFP co-localizes with one of the small GTPases.
BCG Binding (localizes) of
7) Confidence 0.08 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.14 Pain Relevance 0.07
The identification of these various networks bespeaks the complexity of BCG-induced reactions.
BCG Binding (complexity) of
8) Confidence 0.08 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.54 Pain Relevance 0.04
Challenge of J82 with BCG and ChIP generation
BCG Binding (generation) of in J82
9) Confidence 0.08 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.15 Pain Relevance 0
In phase 1, BCG adheres to the urothelium via interaction between the bacterial antigen 85 complex and fibronectin [5,12] and urothelial cells.
BCG Binding (interaction) of in urothelial cells
10) Confidence 0.07 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.59 Pain Relevance 0.26
The literature is remarkably mute on the presence of BCG within the urothelium within 24 hours of administration, and studies that reported on the absence of BCG in the bladder were performed a week after BCG administration, well after the responses documented here occurred and after much of the urothelium had sloughed [66,67].
BCG Binding (absence) of in bladder
11) Confidence 0.07 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.41 Pain Relevance 0.08
Figure 13C indicates the presence of BCG in the urothelium as indicated by the fluorescence of GFP.
BCG Binding (presence) of
12) Confidence 0.07 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.07 Pain Relevance 0
Following amplification of CD8+ T cells using DC, we observed that revaccination with BCG induced detectable, but low frequency of pentamer (KLIANNTRV)+, IFN?
BCG Binding (revaccination) of in T cells
13) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.21 Pain Relevance 0
Subjects enrolled in the clinical trials were all healthy and had previously been vaccinated with BCG.
BCG Binding (vaccinated) of
14) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.37 Pain Relevance 0
CD8+ T cell responses to mycobacteria have been shown to be induced through vaccination with BCG in older subjects, or following latent infection or active disease [30], [35], [36], [37].
BCG Binding (vaccination) of in T cell associated with disease and infection
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.53 Pain Relevance 0
Bacille Calmette-Guérin (BCG), a live attenuated Mycobacterium bovis, which is commonly used in many countries as a vaccine against human tuberculosis, has been shown to strongly induce a Th1-like response [11].
BCG Binding (vaccine) of associated with mycobacterial infection
16) Confidence 0.03 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 1.16 Pain Relevance 0.20

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