INT96861

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.46
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ang) extracellular space (Ang) extracellular region (Ang)
RNA binding (Ang) nucleus (Ang) nuclease activity (Ang)
Anatomy Link Frequency
blood 1
brain 1
hearts 1
podocytes 1
Ang (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 24 99.36 Very High Very High Very High
antagonist 14 98.76 Very High Very High Very High
member 8 1 92.00 High High
Eae 3 91.36 High High
fibrosis 10 88.08 High High
Calcium channel 2 87.28 High High
long-term potentiation 8 86.20 High High
agonist 12 84.80 Quite High
Hippocampus 8 83.68 Quite High
Inflammation 80 80.64 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 21 99.72 Very High Very High Very High
Renal Disease 47 99.58 Very High Very High Very High
Cv Unclassified Under Development 41 99.36 Very High Very High Very High
Reperfusion Injury 6 99.00 Very High Very High Very High
Ureteral Obstruction 84 97.08 Very High Very High Very High
Coronary Heart Disease 26 96.96 Very High Very High Very High
Targeted Disruption 30 96.08 Very High Very High Very High
Natriuresis 10 93.08 High High
Cognitive Disorder 27 91.36 High High
Fibrosis 11 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, these studies could not distinguish between systemic and cardiac interactions of ANP/BNP and Ang II.
Ang Binding (interactions) of
1) Confidence 0.32 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.18 Pain Relevance 0.03
Impact of Mas and Ang-(1–7) on renal ischemia/reperfusion injury
Ang Binding (Impact) of associated with reperfusion injury and ischemia
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.97 Pain Relevance 0.33
If the beneficial effects of Mas deficiency were related to the lacking interaction of Ang-(1–7) with its signaling-associated receptor, detrimental effects of the heptapeptide via Mas on the UUO-initiated pathology in wild-type mice had to be anticipated.
Ang Neg (lacking) Binding (interaction) of associated with ureteral obstruction
3) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.87 Pain Relevance 0.06
To elucidate whether these selective interactions between ANP and Ang II, but not ISO signalling play a role in vivo, in intact hearts, we compared the cardiac hypertrophic responses of CM GC-A KO and respective control littermates [18] to exogenous Ang II or ISO administration.
Ang Neg (not) Binding (interactions) of in hearts
4) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.10 Pain Relevance 0
Angiotensin II (Ang II) has been recognized as an apoptosis inducer in podocytes, but the mechanism of apoptosis induced by Ang II is unclear.
Ang Binding (recognized) of in podocytes associated with apoptosis
5) Confidence 0.25 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.48 Pain Relevance 0.14
Although more research is needed, activation of the (pro)renin receptor may contribute to the pathology of renal disease by increasing local Ang II formation and by increasing the expression of profibrotic mediators.
Ang Binding (formation) of associated with renal disease
6) Confidence 0.25 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.85 Pain Relevance 0.07
Divalinal-Ang IV was initially described as an AT4-receptor antagonist, but displays an IRAP inhibitory property, albeit with lower affinity to Ang IV.
Ang Binding (affinity) of associated with antagonist
7) Confidence 0.10 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0 Pain Relevance 0.09
Furthermore, Ang IV and LVV-H7 were found to be competitive inhibitors of IRAP, inhibiting its aminopeptidase activity by binding to the catalytic site [20,21].
Ang Binding (binding) of
8) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.26 Pain Relevance 0.28
Although the mechanism via which Ang IV and LVV-H7, by binding to IRAP, facilitate memory acquisition and retrieval is not fully understood, it is irrefutable that these peptides enhance memory and are specific, high affinity inhibitors of IRAP.
Ang Binding (binding) of
9) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.49 Pain Relevance 0.11
Furthermore, the expression levels of Ang, brain-derived neurotrophic factor (BDNF), FGF-4, FGF-9, IGFBP-2, IL-8, MIP-1beta, OPG, pulmonary and activation-regulated protein (PARC), TGF-beta2, TIMP-2 and VEGF were significantly associated with the presence of JE; among these, nine cytokines (Ang, BDNF, FGF-4, FGF-9, IGFBP-2, MIP-1beta, PARC, TGF-beta2 and TIMP-2) were hitherto not described in TMD.
Ang Binding (associated) of in brain
10) Confidence 0.05 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.13 Pain Relevance 0
All patients underwent coronary ANG and ECHO within 7 days of taking blood samples.
ANG Binding (underwent) of in blood
11) Confidence 0.02 Published 2010 Journal Kardiol Pol Section Body Doc Link 20425701 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Cardiac Ang II generation was higher in patients with UA than it was in patients with SA or in controls (p < 0.001) due to increased de novo cardiac Ang I formation and its enhanced fractional conversion rate to Ang II.
Ang Binding (formation) of
12) Confidence 0.02 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11451295 Disease Relevance 0.06 Pain Relevance 0

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