INT96864

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.07
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
cleavage 2
eyes 1
poly 1
vascular endothelium 1
microglia 1
Plg (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 99.68 Very High Very High Very High
Endocannabinoid 4 93.76 High High
IPN 5 87.68 High High
Inflammatory mediators 4 75.84 Quite High
long-term potentiation 2 50.16 Quite High
cytokine 12 45.28 Quite Low
ischemia 16 45.04 Quite Low
Inflammation 10 44.92 Quite Low
adenocard 43 5.00 Very Low Very Low Very Low
cva 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 68 99.36 Very High Very High Very High
Diabetes Mellitus 73 97.32 Very High Very High Very High
Metastasis 128 94.48 High High
Thrombosis 3 93.36 High High
Disease 117 87.44 High High
Stroke 43 85.28 High High
Brain Hemorrhage 3 80.76 Quite High
Alzheimer's Dementia 20 77.24 Quite High
INFLAMMATION 19 75.84 Quite High
Cv General 4 Under Development 23 45.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasmin is a serine protease released from the inactive zymogen plasminogen upon cleavage by the tissue-type plasminogen activator (t-PA) or by the urokinase-type plasminogen activator (u-PA) (Figure 1) [11].
Neg (inactive) Localization (released) of Plasmin in cleavage
1) Confidence 0.67 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.08 Pain Relevance 0
Plasmin is a serine protease released from the inactive zymogen plasminogen upon cleavage by the tissue-type plasminogen activator (t-PA) or by the urokinase-type plasminogen activator (u-PA) (Figure 1) [11].
Neg (inactive) Localization (released) of plasminogen in cleavage
2) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.08 Pain Relevance 0.03
Rats receiving rAAV-angiostatin in their right eyes and rAAV-lacZ in their left eyes were sacrificed, and their eyes were enucleated for western blotting analysis at 1, 5, 10, and 15 days after induction of diabetes.
Localization (eyes) of angiostatin in eyes associated with diabetes mellitus
3) Confidence 0.26 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.58 Pain Relevance 0
Finally, activation of P2X7 receptors by low concentration of agonists stimulates the release of the neuroprotective mediator plasminogen from cultured microglia [74].
Localization (release) of plasminogen in microglia associated with agonist
4) Confidence 0.07 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096753 Disease Relevance 0.13 Pain Relevance 0.22
Some studies have shown that tumor progresses after nephrectomy in 22% of patients.[31] This has been hypothesized to be due to the loss of angiostatin, an angiogenic inhibitor secreted by the primary tumor.
Localization (secreted) of angiostatin associated with cancer
5) Confidence 0.03 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2938537 Disease Relevance 0.67 Pain Relevance 0
Controlled release of clot-dissolving tissue-type plasminogen activator from a poly(L-glutamic acid) semi-interpenetrating polymer network hydrogel.
Localization (release) of plasminogen in poly
6) Confidence 0.02 Published 2001 Journal J Control Release Section Title Doc Link 11451495 Disease Relevance 0.09 Pain Relevance 0.24
The injured tissues and vascular endothelium then slowly release tissue plasminogen activator (t-PA) which in turn converts plasminogen to plasmin.
Localization (release) of plasminogen in vascular endothelium
7) Confidence 0.02 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3008863 Disease Relevance 0.45 Pain Relevance 0

General Comments

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