INT96873

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 32
Disease Relevance 11.81
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1B1) endoplasmic reticulum (CYP1B1)
Anatomy Link Frequency
eukaryotic cells 1
endometrium 1
CYP1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 20 99.28 Very High Very High Very High
pain pelvic 5 93.28 High High
anesthesia 51 75.72 Quite High
Glutamate 3 59.76 Quite High
halothane 13 39.20 Quite Low
Potency 1 13.32 Low Low
aspirin 15 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 1822 99.80 Very High Very High Very High
Disease 262 99.80 Very High Very High Very High
Endometriosis (extended) 24 99.28 Very High Very High Very High
Retinoblastoma 16 99.04 Very High Very High Very High
Cancer 73 98.96 Very High Very High Very High
Reprotox - General 3 7 93.28 High High
Stress 93 86.60 High High
Hepatocellular Cancer 6 85.28 High High
Apoptosis 134 85.12 High High
Colon Cancer 121 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study characterizes a human endometrial explant culture model for studying the direct effects of TCDD exposure by assessing the expression of CYP1A1 and CYP1B1 mRNA (Northern blotting), protein (Western blotting), and activity (7-ethoxyresorufin-O-deethylase; EROD) in explants cultured with and without TCDD.
Gene_expression (expression) of CYP1B1 mRNA
1) Confidence 0.78 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.41 Pain Relevance 0.20
Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium.
Gene_expression (expression) of CYP1B1 in endometrium
2) Confidence 0.78 Published 2001 Journal Toxicol. Sci. Section Title Doc Link 11452143 Disease Relevance 0.42 Pain Relevance 0.20
The expression of CYP1A1 and CYP1B1 mRNA was greatest with 10 nM TCDD and increased up to 72 h after initial exposure.
Gene_expression (expression) of CYP1B1 mRNA
3) Confidence 0.78 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.42 Pain Relevance 0.22
The cDNA encoding wild-type CYP1B1 was obtained from Invitrogen (cDNA clone ID 4662252; Carlsbad, CA) and was used as a template to produce different CYP1B1 mutations found in PCG patients using the QuikChange site-directed mutagenesis kit (Stratagene, La Jolla, CA).
Gene_expression (produce) of CYP1B1 associated with glaucoma
4) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.38 Pain Relevance 0
Detection of CYP1B1 in cells by western blot analysis 2 h after the enzymatic assay showed reduced protein levels for the following CYP1B1 mutants: G61E, Y81N, E262X, P400S, and R469W (Figure 4B).
Gene_expression (Detection) of CYP1B1
5) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0 Pain Relevance 0
Regarding protein stability, Jansson and co-workers performed a study using membrane preparations obtained from bacteria expressing recombinant CYP1B1 mutants [33].
Gene_expression (expressing) of CYP1B1
6) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.05 Pain Relevance 0
In accordance with Bejjani and coworkers [4] and as mentioned before, we speculate that residual enzymatic activity from hypomorphic alleles in these subjects could be sufficient to maintain the normal phenotype either alone or in cooperation with compensating variants of unknown modifier genes and/or the increased CYP1B1 expression induced by compounds present in the environment and/or the diet.
Gene_expression (expression) of CYP1B1
7) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.31 Pain Relevance 0
CYP1B1 was also differentially expressed by the triterpenoids.
Gene_expression (expressed) of CYP1B1
8) Confidence 0.72 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.08 Pain Relevance 0
The upregulation of CYP1A1 and CYP1B1 expression by extract and purified cycloartanes cannot be explained by AhR binding.
Gene_expression (expression) of CYP1B1
9) Confidence 0.72 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.19 Pain Relevance 0
A total of six common single nucleotide polymorphisms (SNPs) have been identified in the CYP1B1 region, one upstream of exon 2 (rs2617266) and five coding SNPs (rs10012 [p.
Gene_expression (region) of CYP1B1
10) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2709423 Disease Relevance 0.56 Pain Relevance 0
However, both affected individuals were homozygous in the CYP1B1 region, making it likely that a mutation in the promoter or in some other regulatory region of the gene is responsible for the disease.
Gene_expression (region) of CYP1B1 associated with disease
11) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2709423 Disease Relevance 0.48 Pain Relevance 0
The cDNA encoding wild-type CYP1B1 was obtained from Invitrogen (cDNA clone ID 4662252; Carlsbad, CA) and was used as a template to produce different CYP1B1 mutations found in PCG patients using the QuikChange site-directed mutagenesis kit (Stratagene, La Jolla, CA).
Gene_expression (produce) of CYP1B1 associated with glaucoma
12) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.46 Pain Relevance 0
Functional analysis of CYP1B1 mutations
Gene_expression (mutations) of CYP1B1
13) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0 Pain Relevance 0
Moreover, E229K has been found as the only CYP1B1 allele in a PCG case with moderate goniodysgenesis [41].
Gene_expression (allele) of CYP1B1 associated with glaucoma
14) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.68 Pain Relevance 0
Once again, defective variants of modifier genes and/or environmental compounds could cooperate with loss-of-function CYP1B1 alleles to produce the disease phenotype.
Gene_expression (produce) of CYP1B1 associated with disease
15) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.96 Pain Relevance 0
Heterozygous CYP1B1 mutations in primary congenital glaucoma
Gene_expression (mutations) of CYP1B1 associated with glaucoma
16) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.80 Pain Relevance 0
This discrepancy could be due to different experimental settings since in the present study we measured CYP1B1 levels in eukaryotic cells after inhibiting protein synthesis with cycloheximide.
Gene_expression (levels) of CYP1B1 in eukaryotic cells
17) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.08 Pain Relevance 0
However, mutation P400S, which did not impair the catalytic activity, significantly reduced the CYP1B1 protein levels to about 35% of the initial value.
Gene_expression (levels) of CYP1B1 protein
18) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.23 Pain Relevance 0
Analysis of CYP1B1 mutations
Gene_expression (mutations) of CYP1B1
19) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.74 Pain Relevance 0.08
Detection of CYP1B1 in cells by western blot analysis 2 h after the enzymatic assay showed reduced protein levels for the following CYP1B1 mutants: G61E, Y81N, E262X, P400S, and R469W (Figure 4B).
Gene_expression (mutants) of CYP1B1
20) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0 Pain Relevance 0

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