INT96876

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 10.43
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
Anatomy Link Frequency
monocytes 2
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 24 99.60 Very High Very High Very High
Inflammation 72 99.18 Very High Very High Very High
agonist 25 98.74 Very High Very High Very High
Chronic pancreatitis 5 97.48 Very High Very High Very High
antagonist 11 96.00 Very High Very High Very High
pain pelvic 6 88.72 High High
aspirin 31 50.00 Quite Low
Glutamate 3 50.00 Quite Low
depression 1 47.12 Quite Low
Neuropathic pain 1 46.16 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 45 99.80 Very High Very High Very High
Asthma 164 99.64 Very High Very High Very High
Endometriosis (extended) 27 99.60 Very High Very High Very High
INFLAMMATION 74 99.18 Very High Very High Very High
Apoptosis 130 98.92 Very High Very High Very High
Rhinitis 38 98.78 Very High Very High Very High
Pancreatitis 5 97.48 Very High Very High Very High
Disease 23 95.88 Very High Very High Very High
Cancer 128 94.84 High High
Mycobacterial Infection 81 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the relatively non-toxic AhR agonists caused growth inhibition in pancreatic cancer cells with high AhR expression levels via cell cycle arrest.
Gene_expression (expression) of AhR associated with pancreatic cancer and agonist
1) Confidence 0.77 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.79 Pain Relevance 0.29
The exact site of AhR expression was analysed by in situ hybridization and immunohistochemistry.
Gene_expression (expression) of AhR
2) Confidence 0.77 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.57 Pain Relevance 0.14
AhR expression was analysed by Northern blotting.
Spec (analysed) Gene_expression (expression) of AhR
3) Confidence 0.77 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.49 Pain Relevance 0.11
After culture, AhR and ARNT mRNA expression were quantified by RT-PCR.
Gene_expression (expression) of AhR
4) Confidence 0.70 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.44 Pain Relevance 0.23
Expression of AhR and ARNT mRNA in cultured human endometrial explants exposed to TCDD.
Gene_expression (Expression) of AhR
5) Confidence 0.70 Published 2001 Journal Toxicol. Sci. Section Title Doc Link 11452142 Disease Relevance 0.40 Pain Relevance 0.19
The present study characterizes the expression of AhR and ARNT mRNA in a human endometrial explant culture model in the absence and presence of TCDD exposure.
Gene_expression (expression) of AhR
6) Confidence 0.70 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.38 Pain Relevance 0.17
In pancreatic cancer tissues, AhR mRNA and protein expression were localized in the cytoplasm of pancreatic cancer cells.
Gene_expression (expression) of AhR associated with pancreatic cancer
7) Confidence 0.67 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.84 Pain Relevance 0.29
There was strong AhR mRNA expression in 14 out of 15 pancreatic cancer samples, weak expression in chronic pancreatitis tissues, and faint expression in all normal pancreata.
Gene_expression (expression) of AhR associated with pancreatic cancer and chronic pancreatitis
8) Confidence 0.67 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.71 Pain Relevance 0.24
Constitutive AhR mRNA expression was donor age dependent (increasing with age), while ARNT mRNA expression was donor age and tissue phase dependent (increased in older and proliferative phase specimens).
Gene_expression (expression) of AhR
9) Confidence 0.61 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.42 Pain Relevance 0.19
TCDD treatment significantly increased the expression of AhR mRNA, but not ARNT mRNA.
Gene_expression (expression) of AhR
10) Confidence 0.61 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.43 Pain Relevance 0.23
Similar to results in the parallel study on expression of CYP1A1 mRNA, CYP1B1 mRNA, EROD activity, and CYP1B1 protein, the presence of endometriosis did not affect the expression of AhR or ARNT mRNA, either constitutively or following TCDD exposure.
Gene_expression (expression) of AhR associated with endometriosis
11) Confidence 0.54 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.38 Pain Relevance 0.17
CYP1A1 is known as the classical target of the aryl hydrocarbon receptor (AhR).
Gene_expression (target) of AhR
12) Confidence 0.46 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.05 Pain Relevance 0
CYP1A1 is known as the classical target of the aryl hydrocarbon receptor (AhR).
Gene_expression (target) of aryl hydrocarbon receptor
13) Confidence 0.46 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.05 Pain Relevance 0
Classical AhR ligands and, therefore, CYP1A1 inducers are hydrophobic and planar or coplanar molecules of polycyclic structure.
Gene_expression (inducers) of AhR
14) Confidence 0.40 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0
Expression of the aryl hydrocarbon receptor (AHR) was also slightly downregulated at this point (1.4-fold).
Gene_expression (Expression) of aryl hydrocarbon receptor
15) Confidence 0.39 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.11 Pain Relevance 0
Expression of the aryl hydrocarbon receptor (AHR) was also slightly downregulated at this point (1.4-fold).
Gene_expression (Expression) of AHR
16) Confidence 0.39 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.11 Pain Relevance 0
In HT29 cells curcumin downregulated expression of the CYP1B1 and aryl hydrocarbon receptor genes.
Gene_expression (expression) of aryl hydrocarbon receptor
17) Confidence 0.39 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.31 Pain Relevance 0
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Gene_expression (induction) of AHR in monocytes associated with asthma and rhinitis
18) Confidence 0.21 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.03
In ethnic German populations, the IL-13 Arg110Gln variant has a significant association with high IgE levels.13 In addition, this allele was associated with the asthma phenotype in British and Japanese populations.14 Moreover, IL-13 is necessary and sufficient for the induction of AHR eosinophilic airway inflammation; in the absence of IL-13, this does not progress to AHR.
Neg (not) Gene_expression (progress) of AHR associated with asthma, rhinitis and inflammation
19) Confidence 0.21 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.36 Pain Relevance 0.10
The transcription factor AHR is expressed in the monocytic cell line THP1 that we used in our transfection experiments and inhibits differentiation of monocytes in vitro [24],[25].
Gene_expression (expressed) of AHR in monocytes
20) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.36 Pain Relevance 0

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