INT96877

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 3.25
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
Anatomy Link Frequency
1A2 1
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 12 99.60 Very High Very High Very High
Chronic pancreatitis 2 97.48 Very High Very High Very High
agonist 10 93.44 High High
pain pelvic 3 84.76 Quite High
cINOD 4 76.80 Quite High
Bile 4 75.00 Quite High
antagonist 1 75.00 Quite High
Analgesic 2 74.40 Quite High
aspirin 3 66.64 Quite High
Inflammation 1 57.36 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 18 99.80 Very High Very High Very High
Endometriosis (extended) 12 99.60 Very High Very High Very High
Pancreatitis 2 97.48 Very High Very High Very High
Apoptosis 2 96.56 Very High Very High Very High
Cancer 1 96.48 Very High Very High Very High
Disease 7 92.72 High High
Reprotox - General 3 3 84.76 Quite High
Liver Cancer 1 79.96 Quite High
Hepatocellular Cancer 1 78.00 Quite High
INFLAMMATION 3 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to results in the parallel study on expression of CYP1A1 mRNA, CYP1B1 mRNA, EROD activity, and CYP1B1 protein, the presence of endometriosis did not affect the expression of AhR or ARNT mRNA, either constitutively or following TCDD exposure.
Transcription (expression) of AhR associated with endometriosis
1) Confidence 0.62 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.38 Pain Relevance 0.17
In pancreatic cancer tissues, AhR mRNA and protein expression were localized in the cytoplasm of pancreatic cancer cells.
Transcription (expression) of AhR associated with pancreatic cancer
2) Confidence 0.53 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.84 Pain Relevance 0.29
There was strong AhR mRNA expression in 14 out of 15 pancreatic cancer samples, weak expression in chronic pancreatitis tissues, and faint expression in all normal pancreata.
Transcription (expression) of AhR associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.53 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.71 Pain Relevance 0.24
A xenobiotic response element regulating aryl hydrocarbon receptor (AhR)-mediated UGT1A3 transcription was identified and characterized.
Transcription (transcription) of AhR
4) Confidence 0.52 Published 2008 Journal Arch. Toxicol. Section Abstract Doc Link 18677463 Disease Relevance 0.08 Pain Relevance 0.15
A xenobiotic response element regulating aryl hydrocarbon receptor (AhR)-mediated UGT1A3 transcription was identified and characterized.
Transcription (transcription) of aryl hydrocarbon receptor
5) Confidence 0.52 Published 2008 Journal Arch. Toxicol. Section Abstract Doc Link 18677463 Disease Relevance 0.08 Pain Relevance 0.15
The detrimental effects of TCDD are mediated via the aryl hydrocarbon receptor (AhR), a transcription factor that regulates the expression of the carcinogen-activating enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1.
Transcription (transcription) of aryl hydrocarbon receptor in 1A2
6) Confidence 0.50 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.17 Pain Relevance 0.18
TCDD treatment significantly increased the expression of AhR mRNA, but not ARNT mRNA.
Transcription (expression) of AhR
7) Confidence 0.48 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.43 Pain Relevance 0.23
Constitutive AhR mRNA expression was donor age dependent (increasing with age), while ARNT mRNA expression was donor age and tissue phase dependent (increased in older and proliferative phase specimens).
Transcription (expression) of AhR
8) Confidence 0.48 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.42 Pain Relevance 0.19
Since the transcription of CYP1A1 is under the control of the aryl hydrocarbon receptor (AhR), we examined the ability of sulindac to activate the receptor.
Spec (examined) Transcription (transcription) of AhR
9) Confidence 0.42 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.14 Pain Relevance 0.16

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