INT96879

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.73
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1B1) endoplasmic reticulum (CYP1B1)
CYP1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 16 87.36 High High
pain pelvic 4 85.92 High High
antagonist 15 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Dismenorea 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Rheumatism 5 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 492 98.68 Very High Very High Very High
Hypoxia 85 97.92 Very High Very High Very High
Stress 150 97.60 Very High Very High Very High
Apoptosis 150 87.68 High High
Endometriosis (extended) 21 87.36 High High
Hepatocellular Cancer 5 87.32 High High
Reprotox - General 3 4 85.92 High High
Disease 78 85.60 High High
Breast Cancer 55 81.36 Quite High
Severe Acute Respiratory Syndrome 5 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 24 h, TCDD significantly increased CYP1A1 and CYP1B1 mRNA, and at 72 h, TCDD significantly increased EROD activity and CYP1B1 protein compared to explants cultured without TCDD for similar times.
Positive_regulation (increased) of CYP1B1 mRNA
1) Confidence 0.70 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.35 Pain Relevance 0.18
At 24 h, TCDD significantly increased CYP1A1 and CYP1B1 mRNA, and at 72 h, TCDD significantly increased EROD activity and CYP1B1 protein compared to explants cultured without TCDD for similar times.
Positive_regulation (increased) of CYP1B1 protein
2) Confidence 0.70 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.33 Pain Relevance 0.18
This change is expected to interfere with the ability of mutated protein to perform normal physiologic functions and probably affects severely the normal metabolism of the other molecules that require CYP1B1 participation.
Positive_regulation (require) of CYP1B1
3) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 0.07 Pain Relevance 0
To screen cytochrome P4501B1 (CYP1B1) for causative mutations in Omani patients with a clinical diagnosis of primary congenital glaucoma (PCG)

Methods

Positive_regulation (screen) of cytochrome P4501B1 associated with glaucoma
4) Confidence 0.47 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2709423 Disease Relevance 0.55 Pain Relevance 0
To screen cytochrome P4501B1 (CYP1B1) for causative mutations in Omani patients with a clinical diagnosis of primary congenital glaucoma (PCG)

Methods

Positive_regulation (screen) of CYP1B1 associated with glaucoma
5) Confidence 0.47 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2709423 Disease Relevance 0.56 Pain Relevance 0
As described, we also observed significantly stronger induction of CYP1A1 transcripts than CYP1B1 with black cohosh treatment.
Positive_regulation (induction) of CYP1B1
6) Confidence 0.47 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.06 Pain Relevance 0
In line with these ideas, it has also been proposed that reduced penetrance could be due to a dominant suppressor of the PCG phenotype, which is not linked genetically to CYP1B1 [2], and/or to the inducibility of CYP1B1 by environmental lipophilic agents to which individuals may have been exposed [33].
Positive_regulation (inducibility) of CYP1B1 associated with glaucoma
7) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.30 Pain Relevance 0
In fact, CYP1B1 is inducible upon activation of the aryl hydrocarbon receptor by the binding of ligands such as polycyclic aromatic hydrocarbons [50,51] and by compounds found in certain vegetables [52].
Positive_regulation (inducible) of CYP1B1
8) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.34 Pain Relevance 0
It has also been proposed that reduced penetrance could be due to a dominant suppressor of the PCG phenotype, which is not linked genetically to CYP1B1, and/or the inducibility of CYP1B1 by environmental lipophilic agents to which individuals may have been exposed [45].
Positive_regulation (inducibility) of CYP1B1 associated with glaucoma
9) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 1.08 Pain Relevance 0
A strong upregulation was observed for CYP1A1, and, to a somewhat lesser extent, of CYP1B1.
Positive_regulation (upregulation) of CYP1B1
10) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.27 Pain Relevance 0
The upregulation of CYP1A1 and CYP1B1 may be linked to activation of genes involved with hypoxic stress response, although the consequences of upregulated stress response appear somewhat contradictory.
Positive_regulation (upregulation) of CYP1B1 associated with stress and hypoxia
11) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.61 Pain Relevance 0
Also the AhR target genes CYP1A1 and CYP1B1 were upregulated by the aglycon mixture and with actein albeit at a lower level.


Positive_regulation (upregulated) of CYP1B1
12) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.22 Pain Relevance 0
In a parallel, companion study using this model, TCDD exposure was shown to induce CYP1A1 mRNA, CYP1B1 mRNA, EROD (7-ethoxyresorufin-O-deethylase) activity, and CYP1B1 protein in human endometrial explants.
Positive_regulation (induce) of CYP1B1 mRNA
13) Confidence 0.42 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.41 Pain Relevance 0.20
In a parallel, companion study using this model, TCDD exposure was shown to induce CYP1A1 mRNA, CYP1B1 mRNA, EROD (7-ethoxyresorufin-O-deethylase) activity, and CYP1B1 protein in human endometrial explants.
Positive_regulation (induce) of CYP1B1 protein
14) Confidence 0.42 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452142 Disease Relevance 0.43 Pain Relevance 0.21
This was accompanied by a marked but lower increase of CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1).
Positive_regulation (increase) of CYP1B1
15) Confidence 0.38 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.16 Pain Relevance 0

General Comments

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