INT96886

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.15
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
Caco-2 2
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 4 94.36 High High
Inflammation 22 93.56 High High
pain pelvic 1 93.28 High High
aspirin 10 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 68 99.96 Very High Very High Very High
Endometriosis (extended) 7 94.36 High High
Prostate Cancer 112 94.16 High High
INFLAMMATION 22 93.56 High High
Reprotox - General 3 1 93.28 High High
Frailty 12 93.00 High High
Stress 100 92.00 High High
Apoptosis 115 87.68 High High
Hepatocellular Cancer 5 85.28 High High
Leukemia 6 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulation of CYP1A1 and CYP1B1 expression by extract and purified cycloartanes cannot be explained by AhR binding.
Positive_regulation (upregulation) of Gene_expression (expression) of CYP1A1
1) Confidence 0.64 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.19 Pain Relevance 0
Although the cycloartane-type triterpenoids do not satisfy these structural requirements, gene expression of CYP1A1 was not only induced in our experiments by black cohosh extract but also by the cycloartane aglycons (5.0 ± 1.7 fold, p < 0.01 and 12.2 ± 3.4 fold, p < 0.01) and, to a lower but statistically significant extent, by actein (2.1 ± 0.8, p < 0.05 and 2.0 ± 0.2, p < 0.01).
Positive_regulation (induced) of Gene_expression (expression) of CYP1A1
2) Confidence 0.64 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.06 Pain Relevance 0
The expression of CYP1A1 and CYP1B1 mRNA was greatest with 10 nM TCDD and increased up to 72 h after initial exposure.
Positive_regulation (increased) of Gene_expression (expression) of CYP1A1
3) Confidence 0.49 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.42 Pain Relevance 0.22
A strong upregulation was observed for CYP1A1, and, to a somewhat lesser extent, of CYP1B1.
Positive_regulation (upregulation) of Gene_expression (observed) of CYP1A1
4) Confidence 0.46 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.27 Pain Relevance 0
In smokers, expression of CYP1A1 (p < 0.05), CYP1B1 (p < 0.001), and CYP2C9 (p < 0.05) was increased (p < 0.05) compared with non-smokers, and there was a trend toward increased expression of CYP3A5 (p = 0.0545; Figure 1); however, the expression of CYP2J2 was significantly (p < 0.05) repressed.
Positive_regulation (increased) of Gene_expression (expression) of CYP1A1 associated with nicotine addiction
5) Confidence 0.36 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.86 Pain Relevance 0
CYP1A1 expression did not change in HT29 cells in response to curcumin, however CYP1B1 expression was downregulated by the high concentration of curcumin (Table 2).
Neg (not) Positive_regulation (change) of Gene_expression (expression) of CYP1A1
6) Confidence 0.19 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.12 Pain Relevance 0
In Caco-2 cells curcumin caused a strong downregulation of CYP1A1 gene expression.
Positive_regulation (caused) of Gene_expression (expression) of CYP1A1 in Caco-2
7) Confidence 0.17 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.30 Pain Relevance 0
Addition of the potent AhR ligand TCDD further augmented CYP1A1 upregulation (Figure 5C and data not shown).


Positive_regulation (augmented) of Gene_expression (upregulation) of CYP1A1
8) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.25 Pain Relevance 0
Interestingly, ligand administration did not affect cell growth even though it did upregulate expression of the classic AhR pathway target CYP1A1.
Positive_regulation (upregulate) of Gene_expression (expression) of CYP1A1
9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.68 Pain Relevance 0.05

General Comments

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