INT96888

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.13
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1B1) endoplasmic reticulum (CYP1B1)
CYP1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 4 88.80 High High
pain pelvic 1 78.72 Quite High
Glutamate 3 59.76 Quite High
aspirin 15 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 184 92.48 High High
Disease 33 89.84 High High
Endometriosis (extended) 4 88.80 High High
Stress 3 87.16 High High
Colon Cancer 120 84.96 Quite High
Leukemia 9 80.28 Quite High
Reprotox - General 3 1 78.72 Quite High
Apoptosis 33 56.16 Quite High
Stomach Cancer 6 49.48 Quite Low
Ocular Hypertension 28 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study characterizes a human endometrial explant culture model for studying the direct effects of TCDD exposure by assessing the expression of CYP1A1 and CYP1B1 mRNA (Northern blotting), protein (Western blotting), and activity (7-ethoxyresorufin-O-deethylase; EROD) in explants cultured with and without TCDD.
Negative_regulation (assessing) of Gene_expression (expression) of CYP1B1 mRNA
1) Confidence 0.43 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.41 Pain Relevance 0.20
However, mutation P400S, which did not impair the catalytic activity, significantly reduced the CYP1B1 protein levels to about 35% of the initial value.
Negative_regulation (reduced) of Gene_expression (levels) of CYP1B1 protein
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.23 Pain Relevance 0
Detection of CYP1B1 in cells by western blot analysis 2 h after the enzymatic assay showed reduced protein levels for the following CYP1B1 mutants: G61E, Y81N, E262X, P400S, and R469W (Figure 4B).
Negative_regulation (reduced) of Gene_expression (mutants) of CYP1B1
3) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0 Pain Relevance 0
Several phase-I metabolism genes were downregulated by curcumin, for example expression of CYP1B1 was inhibited by the high curcumin concentration after 3 hours (Table 2) and expression of some other cytochrome P450 genes was downregulated after exposure for 12 hours to the high curcumin concentration (data not shown).
Negative_regulation (inhibited) of Gene_expression (expression) of CYP1B1
4) Confidence 0.29 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.06 Pain Relevance 0.03
CYP1A1 expression did not change in HT29 cells in response to curcumin, however CYP1B1 expression was downregulated by the high concentration of curcumin (Table 2).
Negative_regulation (downregulated) of Gene_expression (expression) of CYP1B1
5) Confidence 0.29 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.12 Pain Relevance 0
In HT29 cells curcumin downregulated expression of the CYP1B1 and aryl hydrocarbon receptor genes.
Negative_regulation (downregulated) of Gene_expression (expression) of CYP1B1
6) Confidence 0.21 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.31 Pain Relevance 0

General Comments

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