INT96889

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.90
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
Caco-2 4
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 4 88.80 High High
pain pelvic 1 77.44 Quite High
aspirin 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 89.84 High High
Stress 2 89.76 High High
Endometriosis (extended) 4 88.80 High High
Leukemia 6 82.88 Quite High
Colon Cancer 80 79.92 Quite High
Reprotox - General 3 1 77.44 Quite High
Apoptosis 22 51.12 Quite High
Cancer 18 40.60 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Hypersensitivity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study characterizes a human endometrial explant culture model for studying the direct effects of TCDD exposure by assessing the expression of CYP1A1 and CYP1B1 mRNA (Northern blotting), protein (Western blotting), and activity (7-ethoxyresorufin-O-deethylase; EROD) in explants cultured with and without TCDD.
Negative_regulation (assessing) of Gene_expression (expression) of CYP1A1
1) Confidence 0.42 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.41 Pain Relevance 0.20
In Caco-2 cells curcumin caused a strong downregulation of CYP1A1 gene expression.
Negative_regulation (downregulation) of Gene_expression (expression) of CYP1A1 in Caco-2
2) Confidence 0.22 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.30 Pain Relevance 0
The most striking response in Caco-2 cells was a strong downregulation of CYP1A1 expression after exposure to both concentrations of curcumin for 3 and 6 hours (Table 3).
Negative_regulation (downregulation) of Gene_expression (expression) of CYP1A1 in Caco-2
3) Confidence 0.22 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.18 Pain Relevance 0

General Comments

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