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Context Info
Confidence 0.07
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

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transport (Orm2) small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
CYP3A4 (Homo sapiens)
Orm2 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 2 50.00 Quite Low


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The disposition of the active enantiomer, R -methadone, can be predicted in part by CYP3A activity and protein binding to alpha1-AGP (ORM2), whereas S-methadone disposition is not well explained by the factors examined in this study.
CYP3A Binding (binding) of ORM2
1) Confidence 0.07 Published 2001 Journal Clin. Pharmacol. Ther. Section Body Doc Link 11452244 Disease Relevance 0 Pain Relevance 0

General Comments

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