INT969

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Context Info
Confidence 0.38
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.03
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (FASTK)
Anatomy Link Frequency
neurons 1
hearts 1
body 1
FASTK (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 20 99.96 Very High Very High Very High
tetrodotoxin 9 99.90 Very High Very High Very High
dorsal root ganglion 73 97.68 Very High Very High Very High
allodynia 2 97.28 Very High Very High Very High
Hyperalgesia 6 96.72 Very High Very High Very High
hyperexcitability 20 95.60 Very High Very High Very High
cytokine 4 93.20 High High
nociceptor 2 90.32 High High
Action potential 3 77.12 Quite High
repetitive firing 2 70.96 Quite High
Disease Link Frequency Relevance Heat
Injury 555 100.00 Very High Very High Very High
Death 28 98.62 Very High Very High Very High
Ganglion Cysts 77 97.68 Very High Very High Very High
Neuropathic Pain 14 97.28 Very High Very High Very High
Hyperalgesia 11 96.72 Very High Very High Very High
Apoptosis 12 91.84 High High
Hemorrhage 130 88.08 High High
Emergencies 21 87.52 High High
Soft Tissue Injuries 12 80.96 Quite High
Hypotension 3 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased lactate, decreased PaO2/FiO2, and positive FAST each had an insignificant relationship with torso injury (P >> 0.05) when increased base deficit and decreased spirometric volume status were included in the logistic regression analysis.
Negative_regulation (decreased) of FAST associated with injury
1) Confidence 0.38 Published 2004 Journal BMC Surg Section Body Doc Link PMC343284 Disease Relevance 1.21 Pain Relevance 0
In line with the overall down- or nonregulation of death-mediating pathways, one of the non-TNF proteins which belong to the group of direct inducers of cell death by extracellular signals, the Fas-activated serine/threonine kinase FASTK, was downregulated after 1 h exposure to L. plantarum.
Negative_regulation (downregulated) of FASTK associated with death
2) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.49 Pain Relevance 0.08
Embryonic Chick hearts aged less than 4 days are not always sensitive to tetrodotoxin, an inhibitor of fast sodium channel.
Negative_regulation (inhibitor) of fast in hearts associated with tetrodotoxin and sodium channel
3) Confidence 0.11 Published 1979 Journal C. R. Acad. Sci., D, Sci. Nat. Section Abstract Doc Link 117932 Disease Relevance 0 Pain Relevance 0.40
As CT scanners are integrated in resuscitation units, whole-body CT diagnosis may replace FAST as a diagnostic method.


Spec (may) Negative_regulation (replace) of FAST in body associated with injury
4) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 1.46 Pain Relevance 0
Recent studies have shown that CCD causes a decrease in fast-inactivating K+ current [15] and an increase in expression of a hyperpolarization-activated cation current (Ih), in addition to an increase in TTX-R Na+ currents in cutaneous, medium-sized DRG neurons [55].
Negative_regulation (decrease) of fast in neurons associated with dorsal root ganglion
5) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.86 Pain Relevance 0.66

General Comments

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