INT96904

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 10.86
Pain Relevance 24.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
spinal 3
spinal cord 2
neurons 2
nucleus 1
amygdala 1
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 102 100.00 Very High Very High Very High
Glutamate 46 100.00 Very High Very High Very High
addiction 17 100.00 Very High Very High Very High
amygdala 455 99.98 Very High Very High Very High
Spinal cord 121 99.98 Very High Very High Very High
withdrawal 120 99.90 Very High Very High Very High
spinothalamic tract 13 99.86 Very High Very High Very High
nMDA receptor 158 99.82 Very High Very High Very High
cINOD 11 99.78 Very High Very High Very High
Calcitonin gene-related peptide 311 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 3 99.98 Very High Very High Very High
Hyperalgesia 59 99.68 Very High Very High Very High
Nociception 160 99.42 Very High Very High Very High
Inflammatory Pain 7 99.40 Very High Very High Very High
Pain 323 98.88 Very High Very High Very High
Morphine Dependence 4 98.76 Very High Very High Very High
Hypersensitivity 19 98.08 Very High Very High Very High
Arthritis 144 96.56 Very High Very High Very High
Neuropathic Pain 46 95.32 Very High Very High Very High
Targeted Disruption 11 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs were also ineffective against PKA catalytic subunits. 3.
Regulation (ineffective) of PKA associated with cinod
1) Confidence 0.44 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.49 Pain Relevance 1.04
In this study, we examined the roles of spinal protein kinase C (PKC) and protein kinase A (PKA) in the BV-induced different types of pain and hypersensitivity in conscious rats.
Spec (examined) Regulation (roles) of PKA in spinal associated with pain, kinase c and hypersensitivity
2) Confidence 0.41 Published 2003 Journal Neurosignals Section Abstract Doc Link 14739559 Disease Relevance 1.28 Pain Relevance 0.56
Our results might indicate that expression of morphine dependence for hypothalamus-pituitary-adrenocortical axis hyperactivity involves PKC but not PKA signaling mechanisms.
Neg (not) Regulation (involves) of PKA in hypothalamus associated with addiction, kinase c, attention deficit hyperactivity disorder and morphine
3) Confidence 0.36 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12323385 Disease Relevance 0.29 Pain Relevance 1.42
The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.
Spec (examine) Regulation (effect) of PKA in nucleus associated with kinase c, withdrawal and morphine
4) Confidence 0.36 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12323385 Disease Relevance 0 Pain Relevance 0.56
In order to assess whether these modifications were related to modified cyclic AMP-dependent protein kinase (PKA) activity, the phosphorylation levels of two other PKA substrates were examined, the GluR1 and NR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and NMDA receptors respectively.
Regulation (related) of PKA associated with nmda receptor
5) Confidence 0.32 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.20
In order to assess whether these modifications were related to modified cyclic AMP-dependent protein kinase (PKA) activity, the phosphorylation levels of two other PKA substrates were examined, the GluR1 and NR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and NMDA receptors respectively.
Regulation (related) of cyclic AMP-dependent protein kinase associated with nmda receptor
6) Confidence 0.32 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.20
However, the phosphorylation of deep STT cells involves both PKA and PKC.
Regulation (involves) of PKA associated with spinothalamic tract
7) Confidence 0.32 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 0.88
Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.
Regulation (Roles) of PKA in spinal associated with c fibre and spinal dorsal horn
8) Confidence 0.27 Published 2004 Journal J. Neurophysiol. Section Title Doc Link 14586032 Disease Relevance 0.09 Pain Relevance 0.98
In acute in vitro seizure models, the anticonvulsant activity of VPA is not mediated through modulation of adenylyl cyclase or PKA.
Regulation (modulation) of PKA
9) Confidence 0.24 Published 2010 Journal Epilepsia Section Body Doc Link 20002144 Disease Relevance 0 Pain Relevance 0
Evidence is presented for roles of both the cAMP-PKA and cGMP-protein kinase G (PKG) pathways in maintaining neuronal hyperexcitability and behavioral hyperalgesia in a neuropathic pain model: chronic compression of the DRG (CCD treatment).
Regulation (roles) of PKA in DRG associated with hyperalgesia, neuropathic pain and hyperexcitability
10) Confidence 0.23 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16120663 Disease Relevance 0.44 Pain Relevance 0.64
In contrast, hyperalgesia induced by prostaglandin E2, in both females and males, was dependent on PKA and NO.
Regulation (dependent) of PKA associated with hyperalgesia
11) Confidence 0.21 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11454025 Disease Relevance 0.76 Pain Relevance 0.67
Potentiation of spinal NMDA-mediated nociception by cocaine- and amphetamine-regulated transcript peptide via PKA and PKC signaling pathways in rats.
Regulation (regulated) of PKA in spinal associated with nociception, pain and cocaine
12) Confidence 0.16 Published 2009 Journal Regul. Pept. Section Title Doc Link 19632277 Disease Relevance 0.27 Pain Relevance 0.46
Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat.
Regulation (contribution) of PKA associated with inflammation and ipn
13) Confidence 0.15 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11454025 Disease Relevance 0.71 Pain Relevance 1.07
Our data suggest that NMDA receptors are the target of PKA and ERK.
Regulation (target) of PKA associated with nmda receptor
14) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.37 Pain Relevance 1.01
The significance of these results is that in the amygdala PKA and ERK, but not PKC, modulate information processing and behavior through separate (not serially arranged) signaling pathways.
Neg (not) Regulation (modulate) of PKA in amygdala associated with amygdala
15) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.55 Pain Relevance 0.85
The effect of PKA treatment on the Ca2+-sensitivity of Fact is illustrated in Fig. 3A, B and C for the Quiescence, Contraction and Isoprenaline group, respectively.
Regulation (effect) of PKA
16) Confidence 0.13 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03
In contrast, CGRP actions in the spinal cord involve both PKA and PKC [40] and modulate NMDA and AMPA receptor function [38,39].
Regulation (involve) of PKA in spinal cord associated with spinal cord and calcitonin gene-related peptide
17) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.41 Pain Relevance 1.14
Pain-related changes in the CeLC include enhanced synaptic transmission and neuronal excitability through a mechanism that is centered on PKA, but not PKC, activation [34].
Regulation (centered) of PKA in neuronal associated with pain, neuronal excitability and amygdala
18) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 1.46 Pain Relevance 1.66
Here we provide direct evidence that the facilitatory effects of CGRP in the CeLC involve PKA, but not PKC, and NMDA receptors.
Neg (not) Regulation (involve) of PKA associated with nmda receptor, amygdala and calcitonin gene-related peptide
19) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.92 Pain Relevance 1.30
In the present study, the participation of the Na(V)1.8 sodium channel was investigated in the development of the peripheral pro-nociceptive state induced by daily intraplantar injections of PGE(2) in rats and its regulation in vivo by protein kinase A (PKA) and protein kinase C epsilon (PKCvarepsilon) as well.
Regulation (regulation) of PKA associated with nociception, kinase c and sodium channel
20) Confidence 0.12 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.25 Pain Relevance 0.25

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