INT96907

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.59
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA4) ATPase activity (ABCA4) plasma membrane (ABCA4)
transmembrane transport (ABCA4)
Anatomy Link Frequency
fat 4
satellite cell 2
rim 1
arms 1
body 1
ABCA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 88.68 High High
Inflammation 90 87.52 High High
Pain 72 83.72 Quite High
palliative 3 80.48 Quite High
imagery 18 66.76 Quite High
pruritus 1 41.92 Quite Low
abdominal pain 1 41.40 Quite Low
Fibrositis 7 33.76 Quite Low
Lasting pain 4 18.44 Low Low
alcohol 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 83 99.80 Very High Very High Very High
Disorder Of Lipid Metabolism 121 97.72 Very High Very High Very High
Lymphedema 5 97.56 Very High Very High Very High
Renal Disease 11 93.88 High High
Aging 77 91.44 High High
Injury 22 90.48 High High
Disorders Of Creatine Metabolism 44 87.84 High High
INFLAMMATION 90 87.52 High High
Pain 81 83.72 Quite High
Metabolic Syndrome 55 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two of these metastases showed a rim-enhancement, without any central enhancement on CT but marked central FDG-uptake on PET scans (Fig. 4).
Positive_regulation (uptake) of rim in rim associated with metastasis
1) Confidence 0.49 Published 2010 Journal Pediatr Radiol Section Body Doc Link PMC2895865 Disease Relevance 0.76 Pain Relevance 0.08
It was concluded that ND and MA both resulted in an increase in FFM greater than dietary counselling alone.
Positive_regulation (increase) of FFM
2) Confidence 0.41 Published 2001 Journal Int. J. Androl. Section Abstract Doc Link 11454075 Disease Relevance 0.15 Pain Relevance 0.08
The increase in FFM was significantly greater in both the nandrolone and megestrol arms than the dietary counselling arm.
Positive_regulation (increase) of FFM in arms
3) Confidence 0.41 Published 2001 Journal Int. J. Androl. Section Abstract Doc Link 11454075 Disease Relevance 0.36 Pain Relevance 0.07
FFM increased significantly in patients receiving ND (3.54 +/- 1.98 kg, p=0.001) and those receiving MA (2.76 +/- 0.55 kg, p=0.002), whereas the change in those receiving dietary counselling alone was not significant.
Positive_regulation (increased) of FFM
4) Confidence 0.41 Published 2001 Journal Int. J. Androl. Section Abstract Doc Link 11454075 Disease Relevance 0.44 Pain Relevance 0
It is likely that much of the increase in FFM was due to CrM given that the potentiation of the FFM gains seen in the current study were quantitatively similar to those previously reported by our group [15], and others [13], using CrM only.
Positive_regulation (increase) of FFM
5) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.12 Pain Relevance 0
In addition to a greater increase in FFM after training with the CrM+CLA supplement, we found that several measurements of strength increased to a greater degree in the supplemented groups.
Positive_regulation (increase) of FFM
6) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0 Pain Relevance 0
It is not possible to determine what proportion of the increase in FFM was due to the CrM and what may have been due to the CLA component of the supplement.
Positive_regulation (increase) of FFM
7) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.18 Pain Relevance 0.03
In conclusion, we have confirmed the beneficial effects of resistance exercise training on increasing FFM, strength, and function in older adults and have added novel data showing that a combination of CrM+CLA lead to greater increases in FFM and losses of fat mass.
Positive_regulation (increases) of FFM in fat
8) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.34 Pain Relevance 0
Together, the aforementioned data suggest that CrM may enhance the resistance exercise induced activation of satellite cells and contribute to the increase in FFM seen in the current study.
Positive_regulation (increase) of FFM in satellite cells
9) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.25 Pain Relevance 0.03
The molecular mechanism(s) behind the observed enhancement of the FFM with CrM were not evaluated in the current study and may have included an increase in satellite cell recruitment [17], [19], lower protein breakdown and oxidation [20], or increased myofibrillar protein accretion [21].
Positive_regulation (enhancement) of FFM in satellite cell
10) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0 Pain Relevance 0
In conclusion, we have confirmed the beneficial effects of resistance exercise training on increasing FFM, strength, and function in older adults and have added novel data showing that a combination of CrM+CLA lead to greater increases in FFM and losses of fat mass.
Positive_regulation (increasing) of FFM in fat
11) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.36 Pain Relevance 0
Resistance exercise training increased FFM more for men (+2.0 kg, P<0.001) compared to women (+1.0 kg, P<0.05), with a significantly greater increase in FFM for the CrM+CLA group (+2.1 kg, P?
Positive_regulation (increase) of FFM
12) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0 Pain Relevance 0
Significant improvements in body composition (increased FFM and lower fat mass) were seen following resistance exercise training only for the CrM+CLA intervention group.
Positive_regulation (increased) of FFM in fat
13) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.65 Pain Relevance 0.11
Previous findings of an augmented increase in FFM following resistance exercise training with CrM administration in older adults [13], [15], were confirmed in the current study.
Positive_regulation (increase) of FFM
14) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0.49 Pain Relevance 0.04
We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (>65 y).
Positive_regulation (increase) of FFM in fat
15) Confidence 0.08 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1994592 Disease Relevance 0.27 Pain Relevance 0.03
When a current is passed through the body, the water-containing tissues primarily conduct the electrical current so that impedance is higher with increased FFM, which is 73% hydrated;28,29 impedance is also increased in lymphedema.30 In other words, impedance increases with increased water in tissues.
Positive_regulation (increased) of FFM in body associated with lymphedema
16) Confidence 0.02 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004643 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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