INT96911

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 46
Total Number 55
Disease Relevance 43.03
Pain Relevance 15.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
podocytes 10
cleavage 4
kidney 4
keratinocytes 4
neurons 3
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 226 100.00 Very High Very High Very High
Trk A 55 100.00 Very High Very High Very High
Eae 30 100.00 Very High Very High Very High
Hyperalgesia 35 99.96 Very High Very High Very High
allodynia 206 99.56 Very High Very High Very High
Dorsal horn 6 99.50 Very High Very High Very High
Spinal cord 49 99.40 Very High Very High Very High
Central nervous system 49 97.76 Very High Very High Very High
long-term potentiation 29 97.72 Very High Very High Very High
Inflammation 295 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 342 100.00 Very High Very High Very High
Hemophilus Infection 267 99.98 Very High Very High Very High
Hyperalgesia 42 99.96 Very High Very High Very High
Nociception 32 99.84 Very High Very High Very High
Injury 103 99.72 Very High Very High Very High
Bullous Skin Disease 382 99.68 Very High Very High Very High
Heat Stress Disorders 19 99.68 Very High Very High Very High
Neuropathic Pain 324 99.56 Very High Very High Very High
Hyperglycemia 348 99.48 Very High Very High Very High
Lung Injury 76 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in phosphorylated p38 was detected by western blotting in dorsal root ganglia (DRG) and spinal cord day 14 after surgery.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of p38 in DRG associated with spinal cord
1) Confidence 0.70 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18584857 Disease Relevance 1.11 Pain Relevance 0.41
While the increased p38 MAPK activity and phosphorylation of MAPKAPK2 in itself is not a novel discovery, the responsiveness of p38 MAPK to hyperosmotic stress has not until now been demonstrated to occur during preimplantation development.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38 MAPK associated with stress
2) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.25 Pain Relevance 0
The increase in p38 phosphorylation is accompanied by an increase in p38 activity, as shown by elevated phosphorylation of ATF-2, a substrate of p38 (Fig 1b).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38
3) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.80 Pain Relevance 1.02
We observe that the increased phosphorylation of p38 MAPK in WT-STZ mice is ameliorated in SOD2-overexpressing mice despite the presence of hyperglycemia.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38 MAPK associated with hyperglycemia
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.38 Pain Relevance 0.03
Densitometric studies which normalized the levels of pp38 to that of total p38 and actin revealed significantly increased p38 phosphorylation in the db/db mouse at 5, 8, and 10 wk of age.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38
5) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.66 Pain Relevance 0.53
The cause of this p38 phosphorylation is unclear, although the effect appears to result from exposure to hyperglycemia.
Positive_regulation (cause) of Phosphorylation (phosphorylation) of p38 associated with hyperglycemia
6) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.16 Pain Relevance 0.87
Cheng et al. found that berberine strongly promotes the phosphorylation of AMPK and p38 MAPK on L6 rat skeletal muscles [21].
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of p38 MAPK in skeletal muscles
7) Confidence 0.57 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.31 Pain Relevance 0
Our experiments show that in podocytes cultured under basal or high glucose conditions, acute exposure to curcumin induced the phosphorylation of both p38MAPK and downstream HSP25.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of p38MAPK in podocytes
8) Confidence 0.55 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.60 Pain Relevance 0.08
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration (up to 4 hours) resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of p38MAPK in podocytes
9) Confidence 0.55 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.51 Pain Relevance 0
In our in vitro studies, the most surprising result was the attenuation of the apoptosis marker, activated caspase-3, along with an increase in phosphorylation of p38MAPK in curcumin-treated podocytes.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38MAPK in podocytes associated with apoptosis
10) Confidence 0.55 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.02 Pain Relevance 0
Cd increased phosphorylation of p38 MAPK, but not of JNK and ERK1/2.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38
11) Confidence 0.54 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.32 Pain Relevance 0.08
While phospho-MAP2K3/MAP2K6 proteins were detected in the cytoplasm and the nucleus, phospho-MAP2K4 proteins were confined to the nuclei, suggesting that p38 MAPK phosphorylation by MAP2K4 may occur predominantly in the nucleus.
Spec (may) Positive_regulation (occur) of Phosphorylation (phosphorylation) of p38 MAPK in nucleus
12) Confidence 0.50 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.15 Pain Relevance 0
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of Mapk14 associated with fluoxetine
13) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.24 Pain Relevance 0.81
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of p38 associated with fluoxetine
14) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.23 Pain Relevance 0.81
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of p38 associated with fluoxetine
15) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.23 Pain Relevance 0.80
Tilly et al., [39]described a 2-fold increase in the enzymatic activity of MAPKAPK2 at 10 minutes after 820 mOsm mannitol-induced hyperosmotic treatment in human intestine 407 cells [39]; while Watts et al. demonstrated in rat medullary thick ascending limb (MTAL) kidney cells a 2.3-fold increase in ATF-2 (downstream transcription factor of p38 MAPK) phosphorylation with 0.3 M mannitol following 15 minutes treatment [40].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 MAPK in kidney
16) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Furthermore, p38 MAPK activity peaked at 15 minutes of 0.2 M sucrose treatment in Chinese hamster ovary cells (CHO-K1) with a 2-fold increase in p38 MAPK phosphorylation [38].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 MAPK in ovary
17) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.06 Pain Relevance 0
Dorsal horn Iba1 immunostaining and phosphorylation of p38 MAPK increased after injury in WT controls but not in KO animals.
Neg (not) Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38 in Dorsal horn associated with targeted disruption, injury and dorsal horn
18) Confidence 0.45 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.32 Pain Relevance 1.31
We observe that the increased phosphorylation of p38 MAPK in WT-STZ mice is ameliorated in SOD2-overexpressing mice despite the presence of hyperglycemia.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38 MAPK associated with hyperglycemia
19) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.38 Pain Relevance 0.03
Whereas, renal arterial and carotid blood flow significantly drop and phosphorylated p38 MAPK and ERK1/2 levels significantly increase in aorta and the cortex of the kidney respectively by two weeks of STZ-induced diabetes [35], little is known about the effects of acute hyperglycemia on neurons.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of p38 MAPK in kidney associated with hyperglycemia and diabetes mellitus
20) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.72 Pain Relevance 0.15

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