INT96912

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 29
Total Number 31
Disease Relevance 18.33
Pain Relevance 8.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
lung 6
liver 4
heart 4
T cells 4
microglia 4
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 78 99.98 Very High Very High Very High
Kinase C 16 99.72 Very High Very High Very High
Leflunomide 10 99.52 Very High Very High Very High
imagery 10 98.80 Very High Very High Very High
Inflammation 230 98.36 Very High Very High Very High
agonist 38 92.88 High High
cytokine 146 92.68 High High
ischemia 8 88.44 High High
Potency 11 88.24 High High
fibrosis 120 86.60 High High
Disease Link Frequency Relevance Heat
Heat Stress Disorders 40 100.00 Very High Very High Very High
Death 56 99.60 Very High Very High Very High
Lung Injury 100 99.36 Very High Very High Very High
Retinoblastoma 3 99.18 Very High Very High Very High
Insulin Resistance 38 99.14 Very High Very High Very High
Obesity 270 98.40 Very High Very High Very High
INFLAMMATION 265 98.36 Very High Very High Very High
Apoptosis 170 98.04 Very High Very High Very High
Targeted Disruption 22 97.80 Very High Very High Very High
Aging 129 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen-induced phosphorylation of JNK in the liver was also enhanced in KK-A(y) mice.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of JNK in liver associated with paracetamol
1) Confidence 0.69 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539006 Disease Relevance 1.11 Pain Relevance 0.62
Acetaminophen-induced phosphorylation of JNK in the liver was also enhanced in KK-A(y) mice.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK in liver associated with paracetamol
2) Confidence 0.69 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539006 Disease Relevance 1.15 Pain Relevance 0.61
Glutathione depletion was preceded by increased levels of c-Jun N-terminal kinase (JNK) phosphorylation at 2 and 6 h after APAP treatment compared with AMAP, whereas AMAP treatment led to increased extracellular signal-regulated protein kinase (ERK) phosphorylation at 2 and 6 h compared with APAP.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK associated with paracetamol
3) Confidence 0.63 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.34 Pain Relevance 0.99
Cardioprotection was abolished by the MAPK inhibitor SB-203580, which also partially suppressed the HS-induced JNK phosphorylation.
Positive_regulation (-) of Phosphorylation (phosphorylation) of JNK associated with heat stress disorders
4) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.19 Pain Relevance 0.15
In conclusion, knockout of GPX1 did not potentiate APAP-induced cell death and related signaling, whereas the SOD1 null blocked APAP-induced hepatic JNK phosphorylation and cell death.
Neg (not) Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK associated with targeted disruption, paracetamol and death
5) Confidence 0.56 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17138759 Disease Relevance 0.73 Pain Relevance 0.65
In DU145 cells normally deficient of the Retinoblastoma (Rb) gene, reactivation of this gene is required for gamma irradiation induced JNK phosphorylation.
Positive_regulation (required) of Phosphorylation (phosphorylation) of JNK associated with retinoblastoma
6) Confidence 0.55 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.76 Pain Relevance 0.03
The levels of phosphorylated JNK and p38 MAPK were increased following mechanical ventilation (20 ml/kg, 4 hours), as determined by Western immunoblot analyses of corresponding phospho- and dephospho- forms (Figure 4A and B).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of JNK
7) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.86 Pain Relevance 0.11
Smoke-induced phosphorylation of JNK suggested that this kinase might participate in the induction of MUC5AC gene expression in the lung cells.
Positive_regulation (-) of Phosphorylation (phosphorylation) of JNK in lung
8) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.30 Pain Relevance 0.05
Smoke-induced phosphorylation of JNK suggested that this kinase might participate in the induction of MUC5AC gene expression in the lung cells.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK in lung
9) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.30 Pain Relevance 0.05
Immunofluorescence imaging further contributed to these results by showing that smoke induced the phosphorylation of JNK, especially in the small airway epithelium.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK in epithelium associated with imagery
10) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.23 Pain Relevance 0.05
Glutathione depletion was preceded by increased levels of c-Jun N-terminal kinase (JNK) phosphorylation at 2 and 6 h after APAP treatment compared with AMAP, whereas AMAP treatment led to increased extracellular signal-regulated protein kinase (ERK) phosphorylation at 2 and 6 h compared with APAP.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of c-Jun N-terminal kinase associated with paracetamol
11) Confidence 0.45 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.34 Pain Relevance 0.99
HS caused an ~25% increase in phosphorylated c-Jun NH2-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of JNK in heart associated with heat stress disorders
12) Confidence 0.44 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.24 Pain Relevance 0.17
HS caused an ~25% increase in phosphorylated c-Jun NH2-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of c-Jun NH2-terminal kinase in heart associated with heat stress disorders
13) Confidence 0.44 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.24 Pain Relevance 0.17
Glutathione depletion was preceded by increased levels of c-Jun N-terminal kinase (JNK) phosphorylation at 2 and 6 h after APAP treatment compared with AMAP, whereas AMAP treatment led to increased extracellular signal-regulated protein kinase (ERK) phosphorylation at 2 and 6 h compared with APAP.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of JNK associated with paracetamol
14) Confidence 0.42 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.34 Pain Relevance 0.98
Cardioprotection was abolished by the MAPK inhibitor SB-203580, which also partially suppressed the HS-induced JNK phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK associated with heat stress disorders
15) Confidence 0.41 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.19 Pain Relevance 0.15
Our observation of enhanced phosphorylation of
               JNK and I?
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of JNK
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.82 Pain Relevance 0.09
In DU145 cells normally deficient of the Retinoblastoma (Rb) gene, reactivation of this gene is required for gamma irradiation induced JNK phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK associated with retinoblastoma
17) Confidence 0.37 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.76 Pain Relevance 0.03
Additionally, NF-kappaB activation is able to prevent JNK phosphorylation caused by 4-HPR [49].
Positive_regulation (caused) of Phosphorylation (phosphorylation) of JNK
18) Confidence 0.37 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.53 Pain Relevance 0
Instead, leflunomide inhibited APAP-induced activation (phosphorylation) of c-jun NH2-terminal protein kinase (JNK), thus preventing downstream Bcl-2 and Bcl-XL inactivation and protecting from mitochondrial permeabilization and cytochrome c release.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of JNK associated with paracetamol and leflunomide
19) Confidence 0.33 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.50 Pain Relevance 1.36
Cd increased phosphorylation of p38 MAPK, but not of JNK and ERK1/2.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK
20) Confidence 0.23 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.33 Pain Relevance 0.08

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