INT96913

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2011
Negated 2
Speculated 7
Reported most in Abstract
Documents 179
Total Number 186
Disease Relevance 130.44
Pain Relevance 32.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
liver 11
hepatocyte 4
skeletal muscle 3
heart 3
neurons 3
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2173 100.00 Very High Very High Very High
cytokine 1022 99.98 Very High Very High Very High
Inflammatory stimuli 19 99.98 Very High Very High Very High
Kappa opioid receptor 4 99.98 Very High Very High Very High
Paracetamol 135 99.82 Very High Very High Very High
nMDA receptor 59 99.80 Very High Very High Very High
Taxol 25 99.74 Very High Very High Very High
diclofenac 24 99.72 Very High Very High Very High
Delta opioid receptors 5 99.64 Very High Very High Very High
Leflunomide 10 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2715 100.00 Very High Very High Very High
INFLAMMATION 2453 100.00 Very High Very High Very High
Stress 1208 100.00 Very High Very High Very High
Starvation 82 99.98 Very High Very High Very High
Insulin Resistance 695 99.92 Very High Very High Very High
Injury 579 99.92 Very High Very High Very High
Diabetes Mellitus 486 99.92 Very High Very High Very High
Reprotox - General 1 983 99.84 Very High Very High Very High
Cancer 1941 99.76 Very High Very High Very High
Lung Injury 252 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the in vivo activation of JNK in the case of smoke inhalation has not yet been studied.
Positive_regulation (activation) of JNK
1) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.49 Pain Relevance 0.03
JNK activation was prominent in the airway epithelial cells (Figure 5).
Positive_regulation (activation) of JNK in epithelial cells
2) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.58 Pain Relevance 0.08
c-Jun N-terminal kinase (JNK) activation is required for the in vitro transcriptional up-regulation of MUC5AC in response to tobacco smoke [11].
Positive_regulation (activation) of JNK associated with nicotine addiction
3) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.61 Pain Relevance 0.04
c-Jun N-terminal kinase (JNK) activation is required for the in vitro transcriptional up-regulation of MUC5AC in response to tobacco smoke [11].
Positive_regulation (activation) of c-Jun N-terminal kinase associated with nicotine addiction
4) Confidence 0.69 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.61 Pain Relevance 0.04
We examined whether VILI affects the activation of JNK1 and p38 MAPK, members of major inflammatory signaling pathways involved in lung injury.
Spec (whether) Positive_regulation (activation) of JNK1 in lung associated with lung injury and inflammation
5) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.81 Pain Relevance 0.12
The levels of phosphorylated JNK and p38 MAPK were increased following mechanical ventilation (20 ml/kg, 4 hours), as determined by Western immunoblot analyses of corresponding phospho- and dephospho- forms (Figure 4A and B).
Positive_regulation (increased) of JNK
6) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.85 Pain Relevance 0.11
The present study aimed to determine whether this interaction results in increased constitutive JNK activity in the absence of GSTP in GstP1/P2(-/-) mice and whether such a phenomenon leads to the up-regulation of genes that are relevant to cell defense.
Spec (whether) Positive_regulation (increased) of JNK
7) Confidence 0.68 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0
We found a significant increase in constitutive JNK activity in the liver and lung of GstP1/P2-/- compared with GstP1/P2(+/+) mice.
Positive_regulation (increase) of JNK in lung
8) Confidence 0.68 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0
The greatest increase in constitutive JNK activity was observed in null liver and was accompanied by a significant increase in activator protein-1 DNA binding activity (8-fold) and in the mRNA levels for the antioxidant protein heme oxygenase-1 compared with wild type.
Positive_regulation (increase) of JNK in liver
9) Confidence 0.68 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0
Pro-inflammatory cytokines activate the mitogen activated protein kinase, c-Jun-N-terminal kinase (JNK) in the liver.
Positive_regulation (activate) of c-Jun-N-terminal kinase in liver associated with inflammation and cytokine
10) Confidence 0.67 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.44 Pain Relevance 0.84
Pre-treatment with TNF-alpha resulted in prolonged activation of JNK (upto 2 hr) in the presence of APAP or CPZ.
Positive_regulation (activation) of JNK associated with paracetamol
11) Confidence 0.67 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 0.94 Pain Relevance 1.03
Pro-inflammatory cytokines activate the mitogen activated protein kinase, c-Jun-N-terminal kinase (JNK) in the liver.
Positive_regulation (activate) of JNK in liver associated with inflammation and cytokine
12) Confidence 0.67 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.44 Pain Relevance 0.85
In conclusion, these findings suggest that extramitochondrial glutathione depletion alters the thiol-disulfide redox state, leading to inhibition of NF-kappaB transactivation of survival genes and to sustained activation of JNK, both of which contribute to the sensitization to TNF-induced apoptosis.
Positive_regulation (activation) of JNK associated with apoptosis
13) Confidence 0.65 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.51 Pain Relevance 0.14
In fact, enhanced JNK activation in IKK?
Positive_regulation (activation) of JNK
14) Confidence 0.64 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.92 Pain Relevance 0.04
were correlated with increased ROS accumulation, which led to JNK and STAT3 activation.
Positive_regulation (activation) of JNK
15) Confidence 0.64 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.22 Pain Relevance 0.07
HS caused an ~25% increase in phosphorylated c-Jun NH2-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period.
Positive_regulation (increase) of c-Jun NH2-terminal kinase in heart associated with heat stress disorders
16) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.24 Pain Relevance 0.17
HS caused an ~25% increase in phosphorylated c-Jun NH2-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period.
Positive_regulation (increase) of JNK in heart associated with heat stress disorders
17) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.24 Pain Relevance 0.17
We previously showed that kappa-opioid receptor activation of JNK by one class of ligand, but not another, caused persistent receptor inactivation.
Positive_regulation (activation) of JNK associated with kappa opioid receptor
18) Confidence 0.59 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534436 Disease Relevance 0.12 Pain Relevance 1.07
Thus, DADLE stimulated phosphorylation of 71kDa ATF-2 and its association with JNK, suggesting that JNK is activated through DORs.
Positive_regulation (activated) of JNK associated with delta opioid receptors
19) Confidence 0.56 Published 2003 Journal Cell. Immunol. Section Abstract Doc Link 12747953 Disease Relevance 0 Pain Relevance 0.34
The APAP treatment activated liver c-jun N-terminal kinase (JNK) in the WT and GPX1(-/-) mice, but not in the SOD1(-/-) mice.
Neg (not) Positive_regulation (activated) of JNK in liver associated with paracetamol
20) Confidence 0.56 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17138759 Disease Relevance 0.50 Pain Relevance 0.67

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