INT96914

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.82
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 168
Total Number 169
Disease Relevance 108.46
Pain Relevance 53.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
P19 8
podocytes 5
neurons 5
cleavage 2
kidney 2
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 80 100.00 Very High Very High Very High
Hyperalgesia 220 99.96 Very High Very High Very High
Nerve growth factor 1578 99.92 Very High Very High Very High
allodynia 1387 99.92 Very High Very High Very High
Trk A 385 99.84 Very High Very High Very High
Morphine 22 99.78 Very High Very High Very High
Brush evoked pain 7 99.60 Very High Very High Very High
Painful diabetic neuropathy 945 99.54 Very High Very High Very High
fibrosis 358 99.52 Very High Very High Very High
Dorsal horn 37 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 943 100.00 Very High Very High Very High
Hyperalgesia 260 99.96 Very High Very High Very High
Neuropathic Pain 1862 99.92 Very High Very High Very High
Hyperglycemia 993 99.84 Very High Very High Very High
Obesity 1901 99.82 Very High Very High Very High
Hemophilus Infection 445 99.82 Very High Very High Very High
Cardiomyopathy 63 99.72 Very High Very High Very High
Disorder Of Lipid Metabolism 166 99.66 Very High Very High Very High
Glioma 26 99.66 Very High Very High Very High
Diabetes Mellitus 2781 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in phosphorylated p38 was detected by western blotting in dorsal root ganglia (DRG) and spinal cord day 14 after surgery.
Phosphorylation (phosphorylated) of p38 in DRG associated with spinal cord
1) Confidence 0.82 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18584857 Disease Relevance 1.11 Pain Relevance 0.41
Immunohistochemistry showed that p38 was phosphorylated in DRG and spinal dorsal horn neurons at this time point.
Phosphorylation (phosphorylated) of p38 in dorsal horn associated with dorsal horn neuron
2) Confidence 0.82 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18584857 Disease Relevance 1.11 Pain Relevance 0.47
While the increased p38 MAPK activity and phosphorylation of MAPKAPK2 in itself is not a novel discovery, the responsiveness of p38 MAPK to hyperosmotic stress has not until now been demonstrated to occur during preimplantation development.
Phosphorylation (phosphorylation) of p38 MAPK associated with stress
3) Confidence 0.81 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.25 Pain Relevance 0
While phospho-MAP2K3/MAP2K6 proteins were detected in the cytoplasm and the nucleus, phospho-MAP2K4 proteins were confined to the nuclei, suggesting that p38 MAPK phosphorylation by MAP2K4 may occur predominantly in the nucleus.
Phosphorylation (phosphorylation) of p38 MAPK in nucleus
4) Confidence 0.81 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.15 Pain Relevance 0
Intrathecal injection of IL-1beta and TNF-alpha significantly increased p38(MAPK) phosphorylation and this was inhibited by myricitrin treatment.
Phosphorylation (phosphorylation) of p38 associated with intrathecal
5) Confidence 0.77 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17678631 Disease Relevance 0.25 Pain Relevance 0.66
Myricitrin prevented cytokine-induced biting behaviour and inhibited p38(MAPK) phosphorylation in response to cytokines stimulation.
Phosphorylation (phosphorylation) of p38 associated with cytokine
6) Confidence 0.77 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17678631 Disease Relevance 0.17 Pain Relevance 0.61
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Phosphorylation (phosphorylation) of p38 associated with fluoxetine
7) Confidence 0.75 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.23 Pain Relevance 0.80
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Phosphorylation (phosphorylation) of Mapk14 associated with fluoxetine
8) Confidence 0.75 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.24 Pain Relevance 0.81
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Phosphorylation (phosphorylation) of p38 associated with fluoxetine
9) Confidence 0.75 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.23 Pain Relevance 0.81
The increase in p38 phosphorylation is accompanied by an increase in p38 activity, as shown by elevated phosphorylation of ATF-2, a substrate of p38 (Fig 1b).
Phosphorylation (phosphorylation) of p38
10) Confidence 0.74 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.79 Pain Relevance 1.01
Western blotting analysis demonstrates significant increases in the levels of phosphorylated p38 MAPK in WT-STZ mice as compared to the WT, SOD2 and SOD2-STZ mice, Figure 4A.
Phosphorylation (phosphorylated) of p38 MAPK
11) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.26 Pain Relevance 0
Whereas, renal arterial and carotid blood flow significantly drop and phosphorylated p38 MAPK and ERK1/2 levels significantly increase in aorta and the cortex of the kidney respectively by two weeks of STZ-induced diabetes [35], little is known about the effects of acute hyperglycemia on neurons.
Phosphorylation (phosphorylated) of p38 MAPK in kidney associated with hyperglycemia and diabetes mellitus
12) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.66 Pain Relevance 0.14
In conclusion, our results indicate that short-term hyperglycemia-induced oxidative stress induces axonal transport deficits in olfactory receptor neurons in conjunction with activation of p38MAPK pathway and tau phosphorylation.
Phosphorylation (phosphorylation) of p38MAPK in olfactory receptor neurons associated with stress, hyperglycemia and eae
13) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.11 Pain Relevance 0.10
The homogenates were then centrifuged at 10,000 g for 5 minutes and supernatant was used to assay for phosphorylated and total p38 MAPK and tau proteins.
Phosphorylation (phosphorylated) of p38 MAPK
14) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0 Pain Relevance 0
We observe that the increased phosphorylation of p38 MAPK in WT-STZ mice is ameliorated in SOD2-overexpressing mice despite the presence of hyperglycemia.
Phosphorylation (phosphorylation) of p38 MAPK associated with hyperglycemia
15) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.37 Pain Relevance 0.03
Upon SOD2 overexpression, the deficits in axonal transport recovered in association with restoration of levels of phosphorylated p38 MAPK and tau protein.
Phosphorylation (phosphorylated) of p38 MAPK
16) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.99 Pain Relevance 0.10
The changes in the phosphorylated levels of p38 MAPK can be ascribed to the alteration of activation status of the kinase at 1-week of hyperglycemia.
Phosphorylation (phosphorylated) of p38 MAPK associated with hyperglycemia
17) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.93 Pain Relevance 0.07
1000 dilution, anti-phospho-p38 MAPK, anti-p38 MAPK (Cell Signaling, Danvers, MA), anti-phospho-Tau (threonine 205, serine 202) (MILLIPORE, Bellerica, MA), 1?
Phosphorylation (phospho) of p38 MAPK
18) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0 Pain Relevance 0
1000 dilution, anti-phospho-p38 MAPK, anti-p38 MAPK (Cell Signaling, Danvers, MA), anti-phospho-Tau (threonine 205, serine 202) (MILLIPORE, Bellerica, MA), 1?
Phosphorylation (phospho) of p38 MAPK
19) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0 Pain Relevance 0
We also hypothesize that hyperglycemia-induced oxidative stress activates the p38 MAPK pathway in association with phosphorylation of tau protein leading to axonal transport deficits in CNS neurons.
Phosphorylation (phosphorylation) of p38 MAPK in neurons associated with stress, hyperglycemia and central nervous system
20) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.31 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox