INT96915

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Context Info
Confidence 0.81
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 73
Total Number 75
Disease Relevance 40.69
Pain Relevance 11.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
liver 4
lung 2
heart 2
quadriceps 1
hepatocyte 1
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 20 99.88 Very High Very High Very High
Spinal cord 35 99.84 Very High Very High Very High
Paracetamol 79 99.82 Very High Very High Very High
Kinase C 33 99.72 Very High Very High Very High
Enkephalin 2 99.66 Very High Very High Very High
ischemia 207 99.32 Very High Very High Very High
Leflunomide 10 99.28 Very High Very High Very High
cytokine 296 99.18 Very High Very High Very High
agonist 57 98.92 Very High Very High Very High
nMDA receptor 1 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 272 100.00 Very High Very High Very High
Demyelinating Disease 24 99.88 Very High Very High Very High
Heat Stress Disorders 33 99.82 Very High Very High Very High
Death 202 99.60 Very High Very High Very High
Lung Injury 232 99.36 Very High Very High Very High
Targeted Disruption 136 99.34 Very High Very High Very High
Cv Unclassified Under Development 152 99.32 Very High Very High Very High
Starvation 7 99.32 Very High Very High Very High
Hepatocellular Cancer 263 99.20 Very High Very High Very High
Hypoxia 19 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of c-Jun NH(2)-terminal kinase (JNK) was analyzed by Western blotting.
Spec (analyzed) Phosphorylation (Phosphorylation) of JNK
1) Confidence 0.81 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539006 Disease Relevance 1.06 Pain Relevance 0.46
Acetaminophen-induced phosphorylation of JNK in the liver was also enhanced in KK-A(y) mice.
Phosphorylation (phosphorylation) of JNK in liver associated with paracetamol
2) Confidence 0.81 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539006 Disease Relevance 1.10 Pain Relevance 0.61
The levels of phosphorylated JNK and p38 MAPK were increased following mechanical ventilation (20 ml/kg, 4 hours), as determined by Western immunoblot analyses of corresponding phospho- and dephospho- forms (Figure 4A and B).
Phosphorylation (phosphorylated) of JNK
3) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.85 Pain Relevance 0.11
The downstream molecules phosphorylated by JNK have been extensively investigated.
Phosphorylation (phosphorylated) of JNK
4) Confidence 0.75 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.75 Pain Relevance 0
Originally, JNKs were identified as protein kinases that phosphorylated c-Jun on serine residues [67]. c-Jun is a well-characterized oncogene, especially in liver [68], and its phosphorylation by JNK may be relevant in HCC development.
Phosphorylation (phosphorylation) of JNK in liver associated with hepatocellular cancer
5) Confidence 0.75 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.70 Pain Relevance 0
Glutathione depletion was preceded by increased levels of c-Jun N-terminal kinase (JNK) phosphorylation at 2 and 6 h after APAP treatment compared with AMAP, whereas AMAP treatment led to increased extracellular signal-regulated protein kinase (ERK) phosphorylation at 2 and 6 h compared with APAP.
Phosphorylation (phosphorylation) of JNK associated with paracetamol
6) Confidence 0.74 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.34 Pain Relevance 0.97
Glutathione depletion was preceded by increased levels of c-Jun N-terminal kinase (JNK) phosphorylation at 2 and 6 h after APAP treatment compared with AMAP, whereas AMAP treatment led to increased extracellular signal-regulated protein kinase (ERK) phosphorylation at 2 and 6 h compared with APAP.
Phosphorylation (phosphorylation) of c-Jun N-terminal kinase associated with paracetamol
7) Confidence 0.74 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.34 Pain Relevance 0.98
HS caused an ~25% increase in phosphorylated c-Jun NH2-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period.
Phosphorylation (phosphorylated) of c-Jun NH2-terminal kinase in heart associated with heat stress disorders
8) Confidence 0.73 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.24 Pain Relevance 0.17
HS caused an ~25% increase in phosphorylated c-Jun NH2-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period.
Phosphorylation (phosphorylated) of JNK in heart associated with heat stress disorders
9) Confidence 0.73 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.24 Pain Relevance 0.17
Cardioprotection was abolished by the MAPK inhibitor SB-203580, which also partially suppressed the HS-induced JNK phosphorylation.
Phosphorylation (phosphorylation) of JNK associated with heat stress disorders
10) Confidence 0.73 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.19 Pain Relevance 0.15
In conclusion, knockout of GPX1 did not potentiate APAP-induced cell death and related signaling, whereas the SOD1 null blocked APAP-induced hepatic JNK phosphorylation and cell death.
Phosphorylation (phosphorylation) of JNK associated with targeted disruption, paracetamol and death
11) Confidence 0.66 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17138759 Disease Relevance 0.73 Pain Relevance 0.65
In DU145 cells normally deficient of the Retinoblastoma (Rb) gene, reactivation of this gene is required for gamma irradiation induced JNK phosphorylation.
Phosphorylation (phosphorylation) of JNK associated with retinoblastoma
12) Confidence 0.65 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.75 Pain Relevance 0.03
Poorly differentiated androgen-insensitive PC3 cells seem somewhat resistant to 4-HPR induced JNK phosphorylation, while androgen-sensitive LNCaP cells appear to be quite sensitive correlating with clinical behavior in breast cancer studies [57,58].
Phosphorylation (phosphorylation) of JNK associated with breast cancer
13) Confidence 0.65 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.77 Pain Relevance 0.04
Hypoxia appears to be another condition in which JNK is phosphorylated.
Phosphorylation (phosphorylated) of JNK associated with hypoxia
14) Confidence 0.65 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.71 Pain Relevance 0.10
Additionally, NF-kappaB activation is able to prevent JNK phosphorylation caused by 4-HPR [49].
Phosphorylation (phosphorylation) of JNK
15) Confidence 0.65 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.52 Pain Relevance 0
JNK when activated can phosphorylate serine 62 on Bcl-xL, which effectively prevents this protein's anti-apoptotic effects [56].
Phosphorylation (phosphorylate) of JNK associated with apoptosis
16) Confidence 0.64 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.37 Pain Relevance 0
Spinal knock-down of TAK1 reduces astrocytic JNK1 phosphorylation in spinal cord tissue after nerve injury [25].
Phosphorylation (phosphorylation) of JNK1 in nerve associated with targeted disruption, nervous system injury and spinal cord
17) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.72 Pain Relevance 0.58
Smoke-induced phosphorylation of JNK suggested that this kinase might participate in the induction of MUC5AC gene expression in the lung cells.
Phosphorylation (phosphorylation) of JNK in lung
18) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.30 Pain Relevance 0.05
Immunofluorescence imaging further contributed to these results by showing that smoke induced the phosphorylation of JNK, especially in the small airway epithelium.
Phosphorylation (phosphorylation) of JNK in epithelium associated with imagery
19) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.23 Pain Relevance 0.05
Western blot analysis was carried out as previously described for phosphorylated and dephosphorylated (total) forms of p38 MAPK and JNK [18], [19].
Phosphorylation (phosphorylated) of JNK
20) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.30 Pain Relevance 0.04

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