INT96916

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.68
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
quadriceps 2
liver 2
nerve 2
adipocytes 2
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 9 100.00 Very High Very High Very High
Spinal cord 34 99.84 Very High Very High Very High
ischemia 4 98.24 Very High Very High Very High
cytokine 36 97.92 Very High Very High Very High
Inflammation 79 93.28 High High
qutenza 7 92.40 High High
diabetic neuropathy 3 90.88 High High
agonist 15 90.56 High High
Dorsal horn neuron 3 85.84 High High
Neuropathic pain 4 77.56 Quite High
Disease Link Frequency Relevance Heat
Heat Stress Disorders 11 100.00 Very High Very High Very High
Targeted Disruption 31 99.72 Very High Very High Very High
Death 58 99.60 Very High Very High Very High
Insulin Resistance 57 99.28 Very High Very High Very High
Nervous System Injury 3 98.84 Very High Very High Very High
Syndrome 3 98.66 Very High Very High Very High
Coronary Artery Disease 1 98.24 Very High Very High Very High
Obesity 264 97.24 Very High Very High Very High
Aging 127 95.92 Very High Very High Very High
Disease 36 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardioprotection was abolished by the MAPK inhibitor SB-203580, which also partially suppressed the HS-induced JNK phosphorylation.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of JNK associated with heat stress disorders
1) Confidence 0.52 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.20 Pain Relevance 0.15
In conclusion, knockout of GPX1 did not potentiate APAP-induced cell death and related signaling, whereas the SOD1 null blocked APAP-induced hepatic JNK phosphorylation and cell death.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of JNK associated with targeted disruption, paracetamol and death
2) Confidence 0.47 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17138759 Disease Relevance 0.74 Pain Relevance 0.65
Additionally, NF-kappaB activation is able to prevent JNK phosphorylation caused by 4-HPR [49].
Negative_regulation (prevent) of Phosphorylation (phosphorylation) of JNK
3) Confidence 0.46 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.58 Pain Relevance 0
Spinal knock-down of TAK1 reduces astrocytic JNK1 phosphorylation in spinal cord tissue after nerve injury [25].
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of JNK1 in nerve associated with targeted disruption, nervous system injury and spinal cord
4) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.73 Pain Relevance 0.58
Our observation of enhanced phosphorylation of
               JNK and I?
Negative_regulation (observation) of Phosphorylation (phosphorylation) of JNK
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.83 Pain Relevance 0.09
expression, and attenuation of Jun NH2-terminal kinase (JNK) phosphorylation.
Negative_regulation (attenuation) of Phosphorylation (phosphorylation) of JNK
6) Confidence 0.22 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494675 Disease Relevance 0.58 Pain Relevance 0
We found that only the phosphorylation of JNK is associated with ROS level in liver among MAPKs.
Negative_regulation (associated) of Phosphorylation (phosphorylation) of JNK in liver
7) Confidence 0.22 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.17 Pain Relevance 0
Previous work has shown that up-regulation of Hsp70 can improve insulin resistance and that this is associated with a decrease in phosphorylation of JNK (c-Jun N-terminal kinase) (Chung et al., 2008).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of JNK associated with insulin resistance
8) Confidence 0.19 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.90 Pain Relevance 0.06
In treated quadriceps there was a decrease in phosphorylated Smad 2/3, a decrease in phosphorylated JNK and an increase in phosphorylated Akt (n?
Negative_regulation (decrease) of Phosphorylation (phosphorylated) of JNK in quadriceps
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0
In our study there was also a decrease in JNK phosphorylation and an increase in Akt phosphorylation following acute inhibition in C57 Bl/6 animals.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of JNK
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.09 Pain Relevance 0
In contrast, blocking PI-3 kinase, p38 kinase and JNK activities by LY294002, SB20358 and SP600125 respectively abolished the phosphorylation of Akt-1, p38 kinase and JNK without affecting the levels of cleaved caspase-3 and -7 (Fig. 4A).
Negative_regulation (blocking) of Phosphorylation (phosphorylation) of JNK
11) Confidence 0.12 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.62 Pain Relevance 0
However, it inhibits the phosphorylation of JNK in the macrophages activated by the conditioned medium derived from adipocytes [17].
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of JNK in adipocytes associated with obesity
12) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 0.90 Pain Relevance 0.23
In contrast, blocking PI-3 kinase, p38 kinase and JNK activities by LY294002, SB20358 and SP600125 respectively abolished the phosphorylation of Akt-1, p38 kinase and JNK without affecting the levels of cleaved caspase-3 and -7 (Fig. 4A).
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of JNK
13) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.49 Pain Relevance 0
Figure 4 demonstrates that U0126 and PD98059 inhibited phosphorylation of MAPK while SB203580, SP600125 and LY294002 effectively blocked phosphorylation of p38 kinase and JNK and Akt-1 respectively (Fig. 4A).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of JNK
14) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.53 Pain Relevance 0
Figure 4 demonstrates that U0126 and PD98059 inhibited phosphorylation of MAPK while SB203580, SP600125 and LY294002 effectively blocked phosphorylation of p38 kinase and JNK and Akt-1 respectively (Fig. 4A).
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of JNK
15) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.45 Pain Relevance 0
Actually, in a model of myocardial ischemia-reperfusion syndrome in C57BL/6 mice, the use of eritoran resulted in smaller infarct, decreased JNK phosphorylation, NF?
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of JNK associated with coronary artery disease, syndrome and ischemia
16) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.88 Pain Relevance 0.20

General Comments

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