INT96917

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 5
Speculated 11
Reported most in Body
Documents 261
Total Number 289
Disease Relevance 173.29
Pain Relevance 88.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal 15
microglia 13
embryo 9
podocytes 6
neuronal 6
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 155 99.98 Very High Very High Very High
Spinal nerve ligature 370 99.96 Very High Very High Very High
Peripheral nervous system 74 99.96 Very High Very High Very High
nociceptor 107 99.90 Very High Very High Very High
Pain 1291 99.84 Very High Very High Very High
Painful diabetic neuropathy 486 99.84 Very High Very High Very High
intrathecal 381 99.84 Very High Very High Very High
Neuropathic pain 2405 99.80 Very High Very High Very High
allodynia 995 99.80 Very High Very High Very High
agonist 432 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1477 100.00 Very High Very High Very High
Nervous System Injury 1309 99.98 Very High Very High Very High
Nociception 263 99.86 Very High Very High Very High
Diabetic Neuropathy 705 99.84 Very High Very High Very High
Hemophilus Infection 178 99.84 Very High Very High Very High
Hyperglycemia 834 99.82 Very High Very High Very High
Neuropathic Pain 3580 99.80 Very High Very High Very High
Cancer 1887 99.80 Very High Very High Very High
Death 512 99.76 Very High Very High Very High
Infection 278 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The focus of this work was to examine the potential role of p38 mitogen activated protein kinase (p38) in a mouse model of bone cancer (osteosarcoma) pain.
Spec (examine) Positive_regulation (activated) of p38 associated with pain, osteogenic sarcomas and bone cancer
1) Confidence 0.70 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18584857 Disease Relevance 0.86 Pain Relevance 0.31
An increase in phosphorylated p38 was detected by western blotting in dorsal root ganglia (DRG) and spinal cord day 14 after surgery.
Positive_regulation (increase) of p38 in DRG associated with spinal cord
2) Confidence 0.70 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18584857 Disease Relevance 1.11 Pain Relevance 0.41
Our results clearly demonstrate that hyperosmotic treatment during culture increased p38 MAPK activity as assessed by increased phosphorylation of its specific downstream substrate, MAPKAPK2.
Positive_regulation (increased) of p38 MAPK
3) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.28 Pain Relevance 0
In this regard it is also possible that 460 mOsm represents a near-maximal stimulus of p38 MAPK activation and thus levels beyond this would not result in any further increase in p38 MAPK activity.
Positive_regulation (increase) of p38 MAPK
4) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
Since glycerol can permeate the cell membrane relatively freely via AQPs, the initial osmotic gradient (from 260 mOsm to 1800 mOsm or 460 mOsm) produced by the addition of glycerol to culture media is rapidly reversed in these treatment groups, alleviating "osmotic stress" that might induce p38 MAPK activity.
Spec (might) Positive_regulation (induce) of p38 MAPK associated with stress
5) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.17 Pain Relevance 0
One of the most exciting outcomes from our study is the differential activation of p38 MAPK that occurred in response to the solute compound used to increase the osmolarity of embryo culture media.
Positive_regulation (activation) of p38 MAPK in embryo
6) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.23 Pain Relevance 0
One would expect that an 1800 mOsm osmotic gradient would activate p38 MAPK to a much greater extent than a 460 mOsm gradient.
Positive_regulation (activate) of p38 MAPK
7) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
A possible explanation could be that despite the difference between 1800 mOsm and 460 mOsm that we may perceive, the embryo may consider both stimuli as equivalent when translating them into responses for activating p38 MAPK.
Positive_regulation (activating) of p38 MAPK in embryo
8) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
These findings are supported by numerous studies that have described the responsiveness of this pathway to hyperosmotic stress, and have indicated that increases in p38 MAPK activity are a common cellular response to hyperosmotic stimuli (reviewed by [9].
Positive_regulation (increases) of p38 MAPK associated with stress
9) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.30 Pain Relevance 0
Based upon our results, we would hypothesize that a prolonged shift in osmotic gradient induces p38 MAPK activity, which in turn regulates AQP expression as a compensatory mechanism in preimplantation embryos.
Positive_regulation (induces) of p38 MAPK in embryos
10) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
While the increased p38 MAPK activity and phosphorylation of MAPKAPK2 in itself is not a novel discovery, the responsiveness of p38 MAPK to hyperosmotic stress has not until now been demonstrated to occur during preimplantation development.
Positive_regulation (increased) of p38 MAPK associated with stress
11) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.25 Pain Relevance 0
The osmotic gradient produced by 1.4 M sucrose (1800 mOsm) or 0.2 M sorbitol (460 mOsm) persists for the duration of treatment, enough to induce p38 MAPK activity.
Positive_regulation (induce) of p38 MAPK
12) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.15 Pain Relevance 0
These results suggest a solute specificity in the induction of CCM2, which agrees with the induction of p38 MAPK activity and phosphorylation of MAPKAPK2 described above.
Positive_regulation (induction) of p38 MAPK
13) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Activated MAP2Ks were detected in the cytoplasm and nucleus of embryos collected from the 1-cell to the blastocyst stage, indicating that the p38 MAPK pathway is activated from the earliest stages of development onward.
Positive_regulation (activated) of p38 MAPK in embryos
14) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
To explore a possible mechanism for the induction of p38 MAPK following incubation in hyperosmotic medium we next examined the influence of exposure to hyperosmotic medium on Ccm2 expression.
Spec (possible) Positive_regulation (induction) of p38 MAPK
15) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
Positive_regulation (induction) of p38 associated with diabetes mellitus, antinociceptive and morphine
16) Confidence 0.67 Published 2007 Journal Indian J. Exp. Biol. Section Abstract Doc Link 17821864 Disease Relevance 0.35 Pain Relevance 0.53
Intrathecal infusion of FKN not only induces mechanical allodynia but also activates p38 in spinal microglia [26].
Positive_regulation (activates) of p38 in microglia associated with allodynia and intrathecal
17) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.43 Pain Relevance 0.95
Nevertheless, the peak activation of p38 and microglia in the spinal cord occurs in the first several days of nerve injury, varying from 3 days to 2 weeks due to different injury conditions [43,48].
Positive_regulation (activation) of p38 in microglia associated with nervous system injury, injury and spinal cord
18) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.25 Pain Relevance 1.03
Interestingly, CCR2, one type of receptors for MCP-1, was expressed in spinal microglia; spinal p38 activation after nerve injury is reduced in CCR-2 null mice [27].
Positive_regulation (activation) of p38 in spinal associated with nervous system injury
19) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.95 Pain Relevance 0.76
Minocycline also inhibits spinal p38 activation in a neuropathic pain condition [40].
Positive_regulation (activation) of p38 in spinal associated with neuropathic pain
20) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.43 Pain Relevance 1.30

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